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Chlorpropamide treatment restores the reduced carrageenan-induced paw edema and pleural exudate volume in diabetic rats

Abstract.

Objective and design:

Knowing that hyperglycemia is a hallmark of vascular dysfunction in diabetes and that neonatal streptozotocin-induced diabetic rats (n-STZ) present reduced inflammatory response, we decided to evaluate the effect of chlorpropamide-lowered blood glucose levels on carrageenan-induced rat paw edema and pleural exudate in n-STZ.

Materials:

Diabetes was induced by STZ injection (160 mg/kg, ip) in neonates (2-day-old) Wistar rats.

Treatment:

n-STZ diabetic rats were treated with chlorpropamide (200mg/kg, 15d, by gavage) 8 weeks after STZ injection.

Methods:

Carrageenan-induced paw edema and pleural exudate volumes were assessed concomitantly with peripheral and exudate leukocyte count. We also evaluated the expression of inducible nitric oxide synthase (iNOS) in lungs of all experimental groups.

Results:

Chlorpropamide treatment improved glucose tolerance, β-cell function (assessed by HOMA-β), corrected paw edema, and pleural exudate volume in n-STZ. Neither leukocyte count nor iNOS expression were affected by diabetes or by chlorpropamide treatment.

Conclusion:

Chlorpropamide treatment by restoring β-cell function, reducing blood sugar levels, and improving glucose tolerance might be contributing to the correction of the reduced inflammatory response tested as paw edema and pleural exudate in n-STZ diabetic rats.

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Correspondence to Zuleica Bruno Fortes.

Additional information

Received 16 February 2007; returned for revision 19 August 2007; received from final revision 15 January 2008; accepted by S. Stimpson 17 March 2008

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Sartoretto, J.L., Melo, G.A., Bersani-Amado, C.A. et al. Chlorpropamide treatment restores the reduced carrageenan-induced paw edema and pleural exudate volume in diabetic rats. Inflamm. res. 57, 438–443 (2008). https://doi.org/10.1007/s00011-008-7211-x

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  • DOI: https://doi.org/10.1007/s00011-008-7211-x

Keywords:

  • Diabetes
  • Paw edema
  • Pleurisy
  • Chlorpropamide