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Innate Lymphoid Cells in Inflammatory Bowel Disease

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is a complex chronic inflammatory condition of the human gut of unknown causes. Traditionally, dysregulated adaptive immune responses are thought to play a major role; however, accumulating evidence suggests that innate immunity also contributes to this process. Innate lymphoid cells (ILCs) are recently identified important components of innate immunity. They have critical roles in immunity, tissue development and remodeling. Numerous researchers have linked ILCs to the pathogenesis of IBD. In this review, we describe recent progress in our understanding about the phenotype and function alterations of ILCs as well as its interactions with other key mucosal cells in the gut of IBD patients. A better delineation of the ILCs’ behavior in the human intestine will contribute to our understanding of ILCs biology and provide valuable insights for potential therapeutic target selection for IBD patients.

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Acknowledgements

This work was supported by the Gatorade Trust through funds distributed by the University of Florida, Department of Medicine.

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Authors and Affiliations

  1. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, 1600 SW Archer Rd, PO Box 100214, Gainesville, FL, 32610, USA

    Jian Li & Sarah C. Glover

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  1. Jian Li
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  2. Sarah C. Glover
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Correspondence to Sarah C. Glover.

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Conflict of Interest

The authors declared no conflicts of interest in this study. Sarah Glover, DO is a consultant for AbbVie, Janssen and Takeda. Sarah Glover, DO has received grant support from AbbVie, Bristol Myers Squibb, Celgene, Gilead, Janssen, Genentech, Millennium, Pfizer, Receptos, Takeda and UCB.

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Li, J., Glover, S.C. Innate Lymphoid Cells in Inflammatory Bowel Disease. Arch. Immunol. Ther. Exp. 66, 415–421 (2018). https://doi.org/10.1007/s00005-018-0519-5

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