Hypoxia-inducible Factor 1 as one of the “Signaling Drivers” of Toll-like Receptor-Dependent and Allergic Inflammation
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Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription complex which plays a crucial role in cellular adaptation to low oxygen availability. In the last years there has been increasing evidence about the role of this factor in inflammatory/innate immune reactions. It has also been found to contribute to different types of allergic inflammation. In this review the current knowledge about the accumulation and role of HIF-1 in Toll-like receptor-mediated and allergic inflammation is summarized. Differential biochemical mechanisms employed to stabilize the protein in different cases are discussed.
KeywordsInflammation Allergy Toll-like receptors Hypoxia HIF-1
We apologize to those researchers whose primary studies that form the basis of our current knowledge in the discussed field could not be cited due to space limitations or were indirectly acknowledged by quoting current reviews. This work was supported by the Royal Society (grant number RG080474 to Dr. V. Sumbayev) and by the start-up grant provided to Dr. Sumbayev by the Medway School of Pharmacy, University of Kent.