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Pathology & Oncology Research

, Volume 24, Issue 2, pp 329–337 | Cite as

Long Non-Coding RNA SNHG6 as a Potential Biomarker for Hepatocellular Carcinoma

  • Maryam Tahmasebi BirganiEmail author
  • Mohammadreza HajjariEmail author
  • Arman Shahrisa
  • Atefeh Khoshnevisan
  • Zahra Shoja
  • Paria Motahari
  • Baharak Farhangi
Original Article

Abstract

Long Non-coding RNAs (lncRNAs) refer to all non-protein coding transcripts longer than 200 nucleotides. Their critical roles in different biological pathways have been already well established. Altered expression of lncRNAs can be involved in the cancer initiation and/or progression. Since patients with hepatocellular carcinoma (HCC) are usually diagnosed in late stages, developing diagnostic methods seems to be essential. In this study, the expression levels of different lncRNAs were systematically analysed in different genomic and transcriptome datasets. The analyses showed that SNHG6 is among the lncRNAs with distinctive dysregulation of expression and copy number variation in HCC tumors compared with normal tissues. The results also suggest that the dysregulation of SNHG6 is highly cancer type specific. Through co-occurrence analyses, we found that SNHG6 and its related co-expressed genes on 8q are involved in the structural integrity of ribosome and translation. This comprehensive in silico analysis, provides a resource for investigating SNHG6 in hepatocellular carcinoma and lays the groundwork for design of next researches.

Keywords

Hepatocellular carcinoma Biomarker Long noncoding RNA SNHG6 Systematic analysis 

Notes

Acknowledgments

This study was affiliated to Ahvaz Jundishapur University of Medical Sciences and Shahid Chamran University of Ahvaz, Iran.

Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflict of interest.

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Copyright information

© Arányi Lajos Foundation 2017

Authors and Affiliations

  • Maryam Tahmasebi Birgani
    • 1
    Email author
  • Mohammadreza Hajjari
    • 2
    Email author
  • Arman Shahrisa
    • 3
  • Atefeh Khoshnevisan
    • 2
  • Zahra Shoja
    • 1
  • Paria Motahari
    • 4
  • Baharak Farhangi
    • 5
  1. 1.Department of Medical Genetics, School of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran
  2. 2.Department of Genetics, Faculty of SciencesShahid Chamran University of AhvazAhvazIran
  3. 3.Department of Molecular Genetics, Faculty of BiosciencesTarbiat Modares UniversityTehranIran
  4. 4.Department of BiotechnologyIranian Research Organization Science & TechnologyTehranIran
  5. 5.Cancer Research CenterTehran University of Medical SciencesTehranIran

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