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Zeitschrift für Kardiologie

, Volume 89, Supplement 9, pp IX96–IX100 | Cite as

Endothelial activation – a strategic event during postischemic myocardial inflammation

  • C. Kupatt
  • H. Habazettl
  • B.F. Becker
  • P. Boekstegers
  • 24 Downloads

Summary

Reperfusion after limited ischemia increases leukocyte adhesion, which may contribute to postischemic myocardial and endothelial stunning. Leukocyte adhesion is enhanced immediately after the onset of reperfusion, indicating rapid regulatory mechanisms, In addition, de novo synthesis of, e. g., adhesion molecules induced by reperfusion has been described, providing a prolonged postischemic inflammatory reaction. Enhanced transcription of adhesion molecules involves NF κB activation which appearch as an essential transcription factor for reperfusion-induced subacute endothelial activation. Both, acute and subacute endothelial activation seem to contribute to the final extent of leukocyte-dependent reperfusion injury and successive treatment of both appears to be a promising therapeutic strategy for postischemic myocardial inflammation and its detrimental effects.

Key words Reperfusion injury – TNF α– PMN – ICAM1 – selectins – reactive oxygen species – endothelial stunning – myocardial stunning 

Copyright information

© Steinkopff Verlag 2000

Authors and Affiliations

  • C. Kupatt
    • 1
  • H. Habazettl
    • 2
  • B.F. Becker
    • 3
  • P. Boekstegers
    • 1
  1. 1.Internal Medicine I, University Klinikum Großhadern, University of Munich, Marchioninistr. 15, 81366 Munich, Germany, E-mail: c.kupatt@lrz.uni-muenchen.deDE
  2. 2.Institute for Surgical Research, University of Munich, Munich, GermanyDE
  3. 3.Physiological Institute, University of Munich, Munich, GermanyDE

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