Advertisement

Annals of Hematology

, Volume 80, Supplement 3, pp B20–B23 | Cite as

5. Report on Workshop: Primary CNS Lymphoma

  • A. Korfel
  • J. Finke
  • I. Schmidt-Wolf
  • E. Thiel
Workshop Report
  • 14 Downloads

Summary

The increase in primary CNS lymphoma (PCNSL) has resulted in a growing interest in this disease. Despite efforts to optimize the management of PCNSL, several therapeutic questions remain unanswered. Due to methodological pitfalls in the clinical trials published thus far, particulary their uni- or oligocenter setting and the small number of patients, it has been difficult to draw definitive conclusions. Future efforts should concentrate on identifying optimal chemotherapy combinations, evaluating the efficacy of modern therapy options such as high-dose chemotherapy supported by autologous blood stem cell transplantation, and clarifying the impact of radiotherapy delay in complete responders to chemotherapy. Standardized neuropsychological testing and quality-of-life assessment are indispensable in future PCNSL trials. Important questions regarding management of PCNSL should be preferably addressed in large multicenter prospective randomized trials.

Keywords Primary CNS lymphoma Chemotherapy Whole brain radiotherapy Neurotoxicity 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • A. Korfel
    • 1
  • J. Finke
    • 2
  • I. Schmidt-Wolf
    • 4
  • E. Thiel
    • 3
  1. 1.Dept. of Hematology, Oncology and Transfusion Medicine, Benjamin Franklin Hospital, Free University Berlin, e-mail akorfel@hotmail.com, Fax: 030 84454468DE
  2. 2.Dept. of Hematology and Oncology, University of FreiburgDE
  3. 3.Dept. of Hematology, Oncology and Transfusion Medicine, Benjamin Franklin Hospital, Free University BerlinDE
  4. 4.Dept. of Neurology, University of BonnDE

Personalised recommendations