Science and Engineering Ethics

, Volume 12, Issue 1, pp 23–39 | Cite as

Managing data for integrity: Policies and procedures for ensuring the accuracy and quality of the data in the laboratory

  • Chris B. Pascal


Management of the research data is an extremely important responsibility of the Principal Investigator (PI) and other members of the research team. Without accurate data, no worthwhile conclusions can be drawn from the research study. Integrity in data management is critical to the success of the research group and to public trust in the research outcomes. One of the primary responsibilities of the PI is to provide proper training to the junior members of the lab. This effort can be buttressed by institutional data policies that are implemented at the group level. Extensive and frequent guidance in good research practices by the PI and other senior research staff is critical to the proper training of new scientists.


research integrity data management training mentor principal investigator 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    RCR resources posted on the ORI website:; accessed on 11/3/05.Google Scholar
  2. 2.
    Institute of Medicine (IOM) (2002) “Integrity in Scientific Research: Creating an Environment that Promotes Responsible Conduct.” National Research Council of the National Academies, Washington, D.C., p. 9.Google Scholar
  3. 3.
    Research misconduct is defined as “fabrication, falsification, or plagiarism in proposing, performing, or reviewing research, or in reporting research results.” 42 CFR 93.103, Federal Register, p.28386, Vol. 70, May 17, 2005.Google Scholar
  4. 4.
    Public Health Service Policies on Research Misconduct, Federal Register, 28370-28400, May 17, 2005, to be codified at 42 CFR Part 93. This regulation is posted at the ORI website at; accessed on 11/3/05.Google Scholar
  5. 5.
    Kalichman, M.W., and Friedman, P.J. (1992) “A Pilot Study of Biomedical Trainees’ Perceptions Concerning Research Ethics.” Academic Medicine 67: 769–775. Eastwood, S. et al. (1996) “Ethical Issues in Biomedical Research: Perception and Practices of Post Doctoral Fellows Responding to a Survey.” Science and Engineering Ethics 2: 89–106.CrossRefGoogle Scholar
  6. 6.
    Martinson, B.C., Anderson, M.S., and de Vries, R. (2005) “Scientists Behaving Badly. Nature 435: 737–738.CrossRefGoogle Scholar
  7. 7.
    National Academy of Sciences. (1992) Responsible Science: Ensuring the Integrity of the Research Process. National Academy Press, Washington, D.C., pp. 5–6.Google Scholar
  8. 8.
    NIH Guide: Final NIH Statement on Sharing Research Data: February 26, 2003, NOT-OD-03-032. For additional guidance, see; accessed 11/3/05.Google Scholar
  9. 9.
    Stanford University Policy: Retention and Access to Research Data. accessed 5/10/2005.Google Scholar
  10. 10.
    Forsham v. Harris, 100 S.Ct. 977 (1980). “We hold here that written data generated, owned, and possessed by a privately controlled organization receiving federal study grants are not ‘agency records’ within the meaning of the Act when copies of those data have not been obtained by a federal agency subject to the FOIA.”Google Scholar
  11. 11.
    45 CFR 74.53, Retention and Access Requirements for Records.Google Scholar
  12. 12.
    Duke University Policy on Data Retention and Access.; accessed on 5/10/05.Google Scholar
  13. 13.
    University of New Hampshire Policy on Ownership and Management of Research Data. Http://; Accessed on 11/8/05Google Scholar
  14. 14.
    Harvard Medical School “Guidelines for Investigators in Scientific Research” and “Guidelines for Investigators in Clinical Research.”;; both accessed on 5/13/05.Google Scholar
  15. 15.
    Survey of Research Integrity Measures Utilized in Biomedical Research Laboratories: Final Report, pp. 35–36, Exhibit 2D, August 29, 2003. Conducted under contract to the American Institutes for Research. The report is posted on the ORI website at; accessed on 11/3/05.Google Scholar

Copyright information

© Opragen Publications 2006

Authors and Affiliations

  1. 1.Office of Research Integrity, Office of Public Health and ScienceDepartment of Health and Human ServicesRockvilleUSA

Personalised recommendations