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Research in Experimental Medicine

, Volume 190, Issue 1, pp 153–162 | Cite as

Effect of medium-chain triglycerides (MCT) as an energy substrate after hepatectomy in rats with streptozotocin-induced diabetes

  • K. Mitsuyoshi
  • Y. Hiramatsu
  • M. Nakagawa
  • M. Yamamura
  • K. Hioki
  • M. Yamamoto
Article

Summary

The suitability of energy substrates used by the remnant liver after a 70% partial hepatectomy was studied in relation to the hepatic energy status in diabetic rats. Rats with streptozotocin-induced diabetes mellitus underwent 70% hepatectomy, and were divided into three groups receiving total parenteral nutrition (TPN) for 24h. One group received standard TPN without fat, while two other groups received standard TPN with medium-chain triglycerides (MCTs) or long-chain triglycerides (LCTs) as a 10% lipid emulsion. All rats of the TPN group without fat died within 24 h. Blood ketone body ratios (acetoacetate/β-hydroxybutyrate), energy charge levels of the remnant liver, and cumulative amounts of 14CO2 in the expired breath during the 6 h following 14C-labeled fat emulsion administration (MCT or LCT) were all significantly higher in the MCT group than in the LCT group 24 h after hepatectomy. These findings suggest that medium-chain fatty acids (MCFAs) as an energy substrate are superior to long-chain fatty acids (LCFAs) during the immediate posthepatectomy phase in diabetics.

Key words

Fat emulsion Triglycerides Diabetes mellitus Hepatectomy (70%) Energy charge Rat 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • K. Mitsuyoshi
    • 1
  • Y. Hiramatsu
    • 1
  • M. Nakagawa
    • 1
  • M. Yamamura
    • 1
  • K. Hioki
    • 1
  • M. Yamamoto
    • 1
  1. 1.Department of SurgeryKansai Medical UniversityMoriguchi, OsakaJapan

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