European Journal of Pediatrics

, Volume 156, Supplement 1, pp S75–S77 | Cite as

Studies of apolipoprotein B-100 metabolism using radiotracers and stable isotopes

  • T. Demant
  • C. J. Packard


Apolipoprotein B metabolism can be investigated in-vivo either by exogenous radiolabeling of preformed lipoproteins or by endogenous labelling of de-novo synthesized apo B using a stable isotope substituted amino acid tracer. The potential of both methods and results obtained by in-vivo studies in genetically determined dys- or hyperlipidaemic subjects will be discussed.

Key words Apolipoprotein B Lipoprotein metabolism Stable isotope kinetics Turnover study 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • T. Demant
    • 1
  • C. J. Packard
    • 2
  1. 1.Institut für Klinische Chemie, Klinikum Großhadern, Marchioninistr. 15, 81377 München, GermanyDE
  2. 2.Department of Pathology and Biochemistry, Royal Infirmary NHS Trust, Glasgow, G31 2ER, UKGB

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