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Regulation of inner ear fluid in the guinea pig cochlea after the application of saturated NaCl solution to the round window membrane

  • K. Hisashi
  • S. Komune
  • T. Nakagawa
  • T. Kimitsuki
  • S. Komiyama
Otology

Abstract

The regulation of K+ and Na+ in the inner ear fluid of the guinea pig was studied after the application of saturated NaCl solution to the round window membrane. K+ and Na+ activities in the scala tympani increased rapidly and then decreased. K+ activity in the scala media increased immediately, but Na+ activity continued to increase during the period of observation. K+ activity in the scala vestibuli continued to increase in the observation period. Na+ activity in the scala vestibuli increased and then decreased. The endocochlear potential decreased immediately to approximately 20% of its initial level. Total activities of K+ and Na+ increased immediately and then decreased in both the scala tympani and scala media. The total activity of K+ and Na+ increased slowly and showed no regulatory decrease in the scala vestibuli. Thus, changing patterns in the total activity of K+ and Na+ were similar for the scala tympani and scala media, but not for the scala media and the scala vestibuli. Different patterns of K+ and Na+ activities among the three scalae indicate that their mechanisms for regulating inner ear fluid differ.

Key words Clochlear physiology Potassium ion and sodium ion transport Endolymph Perilymph 

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • K. Hisashi
    • 1
  • S. Komune
    • 2
  • T. Nakagawa
    • 3
  • T. Kimitsuki
    • 3
  • S. Komiyama
    • 3
  1. 1.Department of Otorhinolaryngology, Yamaguchi Red Cross Hospital, 53–1 Yawatanobaba, Yamaguchi 753–8519, JapanJP
  2. 2.Department of Otorhinolaryngology, Miyazaki Medical College, Kiyotake 889–1692, JapanJP
  3. 3.Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka 812–8582, JapanJP

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