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Transplant International

, Volume 11, Supplement 1, pp S73–S77 | Cite as

Tacrolimus and cyclosporine efficacy in high-risk kidney transplantation

on behalf of the European Multicentre Tacrolimus (FK506) Renal Study Group
  • I. A. Hauser
  • H.-N. Neumayer
  • A. D. Mayer
  • J. Dmitrewski
  • J.-P. Squifflet
  • T. Besse
  • B. Grabensee
  • B. Klein
  • F. W. Eigler
  • U. Heemann
  • R. Pichlmayr
  • M. Behrend
  • Y. Vanrenterghem
  • J. Donck
  • J. van Hooff
  • M. Christiaans
  • J. M. Morales
  • A. Andres
  • R. W. G. Johnson
  • C. Short
  • B. Buchholz
  • N. Rehmert
  • W. Land
  • S. Schleibner
  • J. L. R. Forsythe
  • D. Talbot
  • B.-G. Ericzon
  • C. Brattström
  • K. Claesson
  • F. Mühlbacher
  • E. Pohanka
KIDNEY

Abstract

The efficacy and safety of tacrolimus- and cyclosporine-based immunosuppressive regimens were compared in a prospectively defined subgroup of kidney transplant recipients from the European, open, multicentre, 2 : 1 randomised, parallel group study. Patients were stratified as high risk for immunological events if they had a panel-reactive antibodies grade greater than 80 % and/or a previous transplant functional for less than 1 year. The primary efficacy variables evaluated were the incidence of acute rejection, steroid usage and patient and graft survival. Safety was assessed based on adverse events and laboratory evaluations. At 1 year, the tacrolimus group (n = 22) had a lower incidence of biopsy-proven acute rejection (31.8 %) and a higher graft survival (86.0 %) than the 11 patients in the cyclosporine group (54.5 % and 72.0 %, respectively). The frequencies of adverse events were similar between the two groups. The tacrolimus regimen appears more beneficial for high risk patients than cyclosporine.

Key words Tacrolimus Cyclosporine Kidney transplantation High risk 

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • I. A. Hauser
    • 1
  • H.-N. Neumayer
    • 1
  • A. D. Mayer
    • 2
  • J. Dmitrewski
    • 2
  • J.-P. Squifflet
    • 3
  • T. Besse
    • 3
  • B. Grabensee
    • 4
  • B. Klein
    • 4
  • F. W. Eigler
    • 5
  • U. Heemann
    • 5
  • R. Pichlmayr
    • 6
  • M. Behrend
    • 6
  • Y. Vanrenterghem
    • 7
  • J. Donck
    • 7
  • J. van Hooff
    • 8
  • M. Christiaans
    • 8
  • J. M. Morales
    • 9
  • A. Andres
    • 9
  • R. W. G. Johnson
    • 10
  • C. Short
    • 10
  • B. Buchholz
    • 11
  • N. Rehmert
    • 11
  • W. Land
    • 12
  • S. Schleibner
    • 12
  • J. L. R. Forsythe
    • 13
  • D. Talbot
    • 13
  • B.-G. Ericzon
    • 14
  • C. Brattström
    • 14
  • K. Claesson
    • 14
  • F. Mühlbacher
    • 15
  • E. Pohanka
    • 15
  1. 1.University Erlangen-Nürnberg, Department of Medicine IV, Klinik Nürnberg Süd, D-90471 Nürnberg, Germany Fax + 49-9 11-89 06 47DE
  2. 2.Queen Elizabeth Hospital, Birmingham B15 2TH, UKGB
  3. 3.Université Catholique de Louvain, Cliniques Universitaires Sanit-Luc, B-1200 Bruxelles, BelgiumBE
  4. 4.Heinrich Heine Universität Düsseldorf, D-40225 Düsseldorf, GermanyDE
  5. 5.Universitätsklinik, D-45147 Essen, GermanyDE
  6. 6.Medizinische Hochschule Hannover, D-30625 Hannover, GermanyDE
  7. 7.Universitaire Ziekenhuizen Gasthuisberg, B-3000 Leuven, BelgiumBE
  8. 8.Academisch Ziekenhuis, B-6201 BX Maastricht, BelgiumBE
  9. 9.Hospital Universitario ’12 de Octubre', E-28041 Madrid, SpainES
  10. 10.Manchester Royal Infirmary, Manchester M13 9WL, UKGB
  11. 11.Westfälische Wilhelms Universität, D-48149 Münster, GermanyDE
  12. 12.Ludwig-Maximilians-Universität, Klinikum Großhadern, D-81366 München, GermanyDE
  13. 13.Royal Victoria Infirmary, Newcastle-upon-Tyne NE1 4LP, UKGB
  14. 14.Karolinska Institute, Huddinge Hospital, S-141 86 Huddinge/Uppsala University Hospital, S-751 85 Uppsala, SwedenSE
  15. 15.Allgemeines Krankenhaus, A-1090 Wien, AustriaAT

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