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Pediatric Nephrology

, Volume 14, Issue 8–9, pp 813–815 | Cite as

Plasma brain natriuretic peptides and renal hypertension

  • S. Oana
  • Masaru Terai
  • Masahiro Tanabe
  • Yoichi Kohno
  • Naomi Ohnuma
Brief Report

Abstract 

Three children with renal hypertension are described. Two had histories of neuroblastoma treated by surgical resection and chemotherapy. They both presented later with unilateral atrophic kidney and marked hypertension. Only the child with severe cardiac failure demonstrated high plasma brain natriuretic peptide (BNP) concentrations. The remaining patient had a history of chronic nephritis treated with continuous ambulatory peritoneal dialysis. She also had chronic hypertension and severe cardiac failure. This child demonstrated high plasma BNP levels. The endogenous secretion of BNP is not triggered by hypertension alone, even though exogenous BNP has the pharmacological effect of reducing renin activity.

Key words Brain natriuretic peptide Renal hypertension Plasma renin activity 

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Copyright information

© IPNA - International Pediatric Nephrology Association New York, USA 2000

Authors and Affiliations

  • S. Oana
    • 1
  • Masaru Terai
    • 1
  • Masahiro Tanabe
    • 2
  • Yoichi Kohno
    • 1
  • Naomi Ohnuma
    • 2
  1. 1.Department of Pediatrics, School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan e-mail: shinji@med.m.chiba-u.ac.jp Tel.: +81-43-2262144, Fax: +81-43-2262145JP
  2. 2.Department of Pediatric Surgery, School of Medicine, Chiba University, Chiba, JapanJP

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