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Enteropathogenic Escherichia coli: a pathogen that inserts its own receptor into host cells

  • R. DeVinney
  • A. Gauthier
  • A. Abe
  • B. B. Finlay

Abstract.

Enteropathogenic Escherichia coli (EPEC) is a major cause of infant diarrhea, killing hundreds of thousands of children per year worldwide. Intimate attachment to the host cell leading to the formation of actin-rich pedestals beneath the adhering bacteria is an essential feature of EPEC pathogenesis. EPEC attaches to host cells via the outer membrane adhesin, intimin. It was recently shown that EPEC inserts its own receptor for intimate adherence, Tir (translocated intimin receptor) into the host cell membrane. The focus of this review is on the discovery and characterization of this novel receptor, and our current understanding of its role in pedestal formation. Gram-negative bacterial secretion systems, including type III secretion systems, are reviewed and discussed in the context of Tir delivery into the host cell membrane. The relationship and relevance of in vitro models compared to the actual in vivo situation is essential to understanding disease. We have critically reviewed the use of animal models in studying EPEC infection. Elucidating the function of Tir will contribute to our understanding of how EPEC mediates disease.

Key words. Enteropathogenic Escherichia coli (EPEC); diarrhea; Tir (translocated intimin receptor); cytoskeleton; signal transduction; type III secretion system; in vivo models; rabbits. 

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Copyright information

© Birkhäuser Verlag Basel, 1999

Authors and Affiliations

  • R. DeVinney
    • 1
  • A. Gauthier
    • 1
  • A. Abe
    • 1
  • B. B. Finlay
    • 1
  1. 1.Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia V6T 1Z4 (Canada), Fax +1 604 822 9830, e-mail: bfinlay@unixg.ubc.caCA

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