Advertisement

International Journal of Clinical Oncology

, Volume 5, Issue 6, pp 395–398 | Cite as

Radiation therapy for Kaposi's sarcoma associated with acquired immunodeficiency syndrome: Tokyo Metropolitan Komagome Hospital experience

  • T. Ebara
  • K. Karasawa
  • K. Maebayashi
  • H. Kurosaki
  • H. Ishikawa
  • T. Kaizu
  • Y. Tanaka
  • K. Akagi
  • G. Masuda
ORIGINAL ARTICLE
  • 36 Downloads

Abstract

Background. Kaposi's sarcoma is frequently found in association with acquired immunodeficiency syndrome (AIDS). We report on radiotherapy for patients with AIDS-related Kaposi's sarcoma at Tokyo Metropolitan Komagome Hospital.

Methods. Between April 1991 and May 1997, radiotherapy was given to 11 lesions in eight men with AIDS-related Kaposi's sarcoma to relieve their symptoms. The lesions involved the head and neck region, the legs, and the gastrointestinal tract. Radiotherapy was carried out with 4-MV photon through parallel opposed fields or high energy electrons. Total doses ranged from 20 to 38 Gy, with a median of 30 Gy, delivered in 2- to 3-Gy fractions. Four patients were given other treatments prior to the radiotherapy. Acute reaction was evaluated according to the modified acute radiation morbidity scoring criteria of the Radiation Therapy Oncology Group (RTOG).

Results. Radiotherapy had relieved the symptoms in all patients at completion of this therapy. Lesions that involved the hard palate and vocal cords had completely disappeared. The lesions that received radiotherapy were controlled without symptoms until the patients died. Patients who had the head and neck region treated exhibited severe acute mucosal reaction (at a dose of 30 Gy, there was grade 2 morbidity by modified RTOG criteria, in two patients, and grade 3 in three patients) although the radiation therapy was completed for these patients.

Conclusion. Radiotherapy promises a favorable outcome for symptom relief in AIDS-related Kaposi's sarcoma.

Key words AIDS-related Kaposi's sarcoma Radiotherapy Radiosensitive Japan 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© The Japan Society of Clinical Oncology 2000

Authors and Affiliations

  • T. Ebara
    • 1
  • K. Karasawa
    • 2
  • K. Maebayashi
    • 3
  • H. Kurosaki
    • 4
  • H. Ishikawa
    • 4
  • T. Kaizu
    • 2
  • Y. Tanaka
    • 5
  • K. Akagi
    • 6
  • G. Masuda
    • 7
  1. 1.Department of Radiology, Municipal Kanbara General Hospital, 2500-1 Nakanogo, Fujikawa-machi, Ihara-gun, Shizuoka 421-3306, Japan Tel. +81-545-81-2211; Fax +81-545-81-2208 e-mail: tmebara@d2.dion.ne.jpJP
  2. 2.Department of Radiology, Tokyo Metropolitan Komagome Hospital, Tokyo, JapanJP
  3. 3.Division of Radiation Medicine, Center of Matcher Charged Particle Therapy, National Institute of Clinical Radiological Sciences, Chiba, JapanJP
  4. 4.Department of Radiology and Radiation Oncology, Gunma University School of Medicine, Gunma, JapanJP
  5. 5.Department of Radiology, Nippon University, Tokyo, JapanJP
  6. 6.Department of Dermatology, Tokyo Metropolitan Komagome Hospital, Tokyo, JapanJP
  7. 7.Department of Infectious Disease, Tokyo Metropolitan Komagome Hospital, Tokyo, JapanJP

Personalised recommendations