Bioprocess Engineering

, Volume 23, Issue 2, pp 199–203 | Cite as

A structured growth model for Cynara cardunculus cell suspension

  • P. M. N. A. C. Pires Cabral
  • M. E. Lima Costa
  • J. M. S. Cabral


In this study a model was developed to describe the growth of Cynara cardunculus L. suspended cells as a function of the availability of two substrates, sucrose as the carbon and energy source and phosphate. It was assumed that the maintenance energy need was fulfilled by the consumption of extracellular carbohydrates, in non-limiting conditions, or by the consumption of structural biomass when sucrose is depleted. A production of secondary metabolites was also assumed. This model was developed based on a structured model previously described by Van Gulik et al. (1993). The model was applied to the experimental results of C. cardunculus suspended cells grown in a Gamborg B5 medium supplemented with 2% sucrose, using a non-linear regression program.


Phosphate Biomass Sucrose Carbohydrate Cell Suspension 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • P. M. N. A. C. Pires Cabral
    • 1
  • M. E. Lima Costa
    • 2
  • J. M. S. Cabral
    • 3
  1. 1.Escola Superior de Tecnologia, Universidade do Algarve, Campus da Penha, 8000 Faro, PortugalPT
  2. 2.Unidade de Ciências e Tecnologias Agrárias, Universidade do Algarve, Campus de Gambelas, 8000 Faro, PortugalPT
  3. 3.Laboratório de Engenharia Bioquímica, Centro de Engenharia Biológica e Química, Instituto Superior Técnico, 1000 Lisboa, PortugalPT

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