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Bioprocess Engineering

, Volume 19, Issue 4, pp 285–288 | Cite as

Optimization of medium composition by response surface methodology for the production of tartaric acid by Gluconobacter suboxydans

  • D. Mantha
  • Z. Aslam Basha
  • T. Panda
Article

Abstract

The combined effect of sorbitol and yeast extract of the medium on tartaric acid production by Gluconobacter suboxydans, NCIM 2049, was studied in batch fermentation while keeping the temperature (30 °C) and pH (6.2) constant. Response surface methodology was used to obtain quadratic models for the production of tartaric acid. The multiple coefficients of regression between 0.8945 and 0.9820 was obtained during the process. The optimum medium composition comprising 20 kg/m3 sorbitol and 2 kg/m3 yeast extract was verified experimentally by observing the variation of cell mass and tartaric acid production with time.

Keywords

Fermentation Combine Effect Yeast Extract Response Surface Sorbitol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • D. Mantha
    • 1
  • Z. Aslam Basha
    • 1
  • T. Panda
    • 1
  1. 1.Biotechnology Research Centre, Department of Chemical Engineering, Indian Institute of Technology Madras, Chennai 600 036, IndiaIN

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