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Bioprocess Engineering

, Volume 16, Issue 6, pp 323–329 | Cite as

Modelling of E.coli fermentations: comparison of multicompartment and variable structure models

  • B. Tartakovsky
  • M. Sheintuch
  • J.-M. Hilmer
  • T. Scheper

Abstract

 Two novel approaches for modelling processes that can be described by a sequence of phases (metabolic states) are suggested and applied to Escherichia Coli fermentations. The first approach uses a multi-compartment model framework, coupled with knowledge-based logic. In the second approach the multi-compartment model is reduced into the Variable Structure Model consisting of a battery of alternative submodels, each of which qualitatively represents one of the process steps. Furthermore, simulated intracellular process variables are compared with the output of a multi-wavelength fluorosensor and excitation-emission pairs that predict best these variables are identified.

Keywords

Fermentation Variable Structure Process Variable Process Step Model Framework 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • B. Tartakovsky
    • 1
  • M. Sheintuch
    • 1
  • J.-M. Hilmer
    • 2
  • T. Scheper
    • 2
  1. 1.Department of Chemical Engineering, Technion, Haifa 32000, IsraelIL
  2. 2.Institute für Biochemie, Muenster 48149, GermanyDE

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