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Parasitology Research

, Volume 87, Issue 4, pp 275–280 | Cite as

Comparative metabolism of albendazole and albendazole sulphoxide by different helminth parasites

  • H. D. Solana
  • J. A. Rodriguez
  • C. E. Lanusse
ORIGINAL PAPER

Abstract

Albendazole (ABZ) is a broad-spectrum benzimidazole anthelmintic widely used in human and veterinary medicine. The aim of the current work was to characterise the sulphoxidative metabolism of ABZ, and the sulphoreduction of ABZ sulphoxide (ABZSO), by microsomal (Ms) and cytosolic (Cyt) fractions of three different helminth species: Fasciola hepatica, Moniezia expansa and Ascaris suum. After the incubation assays, parasite material was analysed by HPLC to characterise the metabolic product formed. Both the Ms and Cyt fractions of the three parasites studied were able to oxidise ABZ into ABZSO in a non-enantioselective fashion. Oxidation of ABZ was greater in the Ms fraction of the trematode (50%) than in both cestode (19%) and nematode (14%) parasites. Only the incubation of ABZSO with both subcellular fractions of M. expansa generated ABZ as a metabolic product. The results obtained here indicate that helminths have the capacity to biotransform benzimidazole compounds; however, this metabolic activity differs qualitatively and quantitatively among helminth species.

Keywords

Metabolic Activity Current Work Veterinary Medicine Benzimidazole Subcellular Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • H. D. Solana
    • 1
  • J. A. Rodriguez
    • 1
  • C. E. Lanusse
    • 2
  1. 1.Laboratorio de Biología Celular y Molecular, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires 7000, Campus Universitario, Tandil, Argentina e-mail: hsolana@vet.unicen.edu.arAR
  2. 2.Laboratorio de Farmacología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Campus Universitario, Tandil, ArgentinaAR

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