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European Journal of Pediatrics

, Volume 159, Issue 10, pp 764–766 | Cite as

Improved dysgammaglobulinaemia in congenital rubella syndrome after immunoglobulin therapy: correlation with CD154 expression

  • Nobuaki Kawamura
  • Akiko Okamura
  • Hirofumi Furuta
  • Shigetaka Katow
  • Masafumi Yamada
  • Ichiro Kobayashi
  • Motohiko Okano
  • Kunihiko Kobayashi
  • Yukio Sakiyama
ORIGINAL PAPER

Abstract

A boy with congenital rubella syndrome developed dysgammaglobulinaemia with elevated serum levels of IgM. CD154 was not induced on his peripheral blood mononuclear cells when rubella virus RNA was detected in his throat swabs and peripheral blood by reverse transcriptase polymerase chain reaction. Following intravenous immunoglobulin therapy, improvement of immunoglobulin abnormalities, disappearance of rubella virus and normalisation of CD154 expression were demonstrated.

Conclusion These findings implicate the efficacy of intravenous immunoglobulin therapy for dysgammaglobulinaemia in congenital rubella syndrome and a role of CD154 for a prolonged virus infection.

Key words Congenital rubella syndrome Dysgammaglobulinaemia CD154 Intravenous immunoglobulin therapy 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Nobuaki Kawamura
    • 1
  • Akiko Okamura
    • 1
  • Hirofumi Furuta
    • 1
  • Shigetaka Katow
    • 2
  • Masafumi Yamada
    • 1
  • Ichiro Kobayashi
    • 1
  • Motohiko Okano
    • 1
  • Kunihiko Kobayashi
    • 1
  • Yukio Sakiyama
    • 3
  1. 1.Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898JP
  2. 2.Department of Viral Disease and Vaccine Control, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo, JapanJP
  3. 3.Department of Human Gene Therapy, Hokkaido University School of Medicine, Sapporo, JapanJP

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