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Virchows Archiv

, Volume 436, Issue 2, pp 138–139 | Cite as

Splenic smooth-muscle tumors in children with acquired immunodeficiency syndrome: report of two cases of this unusual location with evidence of an association with Epstein-Barr virus

  • V. Barbashina
  • D. S. Heller
  • M. Hameed
  • E. Albanese
  • M. Goldstein
  • B. Dashefsky
  • A. Dieudonne
  • R. Chakraborty
Original Article

Abstract 

Smooth-muscle neoplasms are rarely located in the spleen. They have been previously reported in five cases of children with human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS). Two cases of children with HIV infection/AIDS with autopsy and surgical pathology evidence of multiple smooth-muscle neoplasms with splenic involvement are presented. DNA was extracted from histology slides in both cases for analysis for Epstein Barr (EB) virus. In both cases, the presence of EB virus was confirmed. This paper documents two additional cases of the unusual phenomenon of splenic involvement by smooth-muscle neoplasms in the setting of AIDS in childhood and further supports the role of EB virus in the development of these neoplasms.

Key words Smooth-muscle tumors AIDS Epstein-Barr virus 

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • V. Barbashina
    • 1
  • D. S. Heller
    • 1
  • M. Hameed
    • 1
  • E. Albanese
    • 1
  • M. Goldstein
    • 1
  • B. Dashefsky
    • 2
  • A. Dieudonne
    • 2
  • R. Chakraborty
    • 2
  1. 1.Department of Pathology and Laboratory Medicine, UH/E141, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA e-mail: hellerds@umdnj.edu Tel.: +1-973-9720751 Fax: +1-973-9725724US
  2. 2.Department of Pediatrics, Division of Pediatric Pulmonology, Allergy, Immunology and Infectious Disease, UMDNJ-New Jersey Medical School, NJ, USAUS

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