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Journal of Neurology

, Volume 247, Issue 2, pp 102–105 | Cite as

Oral pulsed high-dose dexamethasone for myositis

  • M. F. G. van der Meulen
  • J. E. Hoogendijk
  • J. H. J. Wokke
  • M. de Visser
Original Communication

Abstract

To study the short-term effect of oral pulsed high-dose dexamethasone for myositis we treated eight newly diagnosed patients with three 28-day cycles of oral dexamethasone. Primary outcome measures were muscle strength, pain, and serum creatine kinase activity. Six patients responded. Side effects were mild. At follow-up five responders were still in remission, without ¶medication. Pulsed high-dose ¶dexamethasone seems beneficial in myositis. A larger, prednisone-controlled trial is justified to analyze long-term efficacy.

Key words Polymyositis Dermatomyositis Therapy Pulsed ¶dexamethasone 

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Copyright information

© Steinkopff Verlag 2000

Authors and Affiliations

  • M. F. G. van der Meulen
    • 1
  • J. E. Hoogendijk
    • 1
  • J. H. J. Wokke
    • 1
  • M. de Visser
    • 2
  1. 1.Department of Neurology, University Medical Centre, PO Box 85500, 3508 GA Utrecht, The Netherlands e-mail address: M.F.G.vdMeulen@neuro.azu.nl Tel.: +31-30-2507978, +31-30-2506480 Fax: +31-30-2522782NL
  2. 2.Department of Neurology, Academic Medical Centre, University of Amsterdam, The NetherlandsNL

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