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Archives of Dermatological Research

, Volume 290, Supplement 1, pp S37–S46 | Cite as

Collagenase-1 and collagen in epidermal repair

  • B. K. Pilcher
  • B. D. Sudbeck
  • J. A. Dumin
  • H. G. Welgus
  • W. C. Parks

Abstract An invariable feature of wounded skin, whether a normally healing or chronic lesion, is the expression of collagenase-1 by migrating basal keratinocytes. Collagenase-1 is a member of the matrix metalloproteinase family of enzymes and is the principal human enzyme which cleaves native fibrillar collagen. Following injury, basal keratinocytes move from the basement membrane and interact with new connective tissue proteins in the dermis and wound bed. Contact with native type I collagen, the most abundant protein in the dermis, induces expression of collagenase-1. This metalloproteinase cleaves collagen, thereby altering its structure and, hence, the affinity to which cells bind it. Thus, collagenase-1 serves a beneficial role in wound healing by facilitating the movement of keratinocytes over the collagen-rich dermis during reepithelialization.

Keywords

Collagen Enzyme Connective Tissue Wound Healing Basement Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • B. K. Pilcher
    • 1
  • B. D. Sudbeck
    • 1
  • J. A. Dumin
    • 1
  • H. G. Welgus
    • 1
  • W. C. Parks
    • 1
  1. 1.Dermatology Division, Department of Medicine, Barnes-Jewish Hospital North, Washington University School of Medicine, 216 S. Kings Highway Blvd., St. Louis, MO 63110, USA e-mail: bparks@imgate.wustl.edu Tel. +1-314-454-7543, Fax +1-314-454-5372US

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