Advertisement

Acta Neuropathologica

, Volume 99, Issue 1, pp 39–47 | Cite as

Comparative morphometric evaluation of peripheral nerves and muscle fibers in myotonic dystrophy

  • J. -F. Wang
  • J. M. Schröder
Regular paper

Abstract

We compared peripheral nerve fibers and muscle fibers in myotonic dystrophy (MD) using a computer-assisted device for morphometry. In the 17 cases with MD studied, the sural nerves of 14 cases (82%) showed various degrees of reduction of the myelin sheath area (MSA) per endoneurial area. Of these, 8 cases (47%) presented with a mild reduction of the MSA, 5 cases (29.4%) with moderate reduction, and one case (6%) with severe reduction. The number of myelinated nerve fibers was not significantly reduced in MD when compared with control nerves, due to clusters of small regenerated nerve fibers. The mean diameter of the muscle fibers in 6 of the 17 cases was less than 40 μm. Of these 6 severely affected cases, ¶5 revealed a considerable reduction of the MSA. Other cases, which appeared to be normal in respect to the diameter of muscle fibers, showed various degrees of reduction of the MSA. Thus, there is usually, but not always a morphometric correlation of the severity of changes between peripheral nerves and muscle. The severity of the peripheral neuropathy appears to depend largely on the patient’s age, the stage of the disorder, and the time of progression. Electron microscopic examination of sural nerves showed significant, though non-specific pathological changes.

Key words Sural nerve Muscle fiber diameter Morphometry Electron microscopy Myotonic ¶dystrophy 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • J. -F. Wang
    • 1
  • J. M. Schröder
    • 1
  1. 1.Institute of Neuropathology, Medical Faculty of the Technical University of Aachen, Pauwelsstraße 30, D-52057 Aachen, Germany e-mail: neupath@amsd.imib.rwth-Aachen.de Tel.: +49-241-8089428; Fax: +49-241-8888416DE

Personalised recommendations