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Experimental Brain Research

, Volume 116, Issue 3, pp 519–524 | Cite as

Interferon modulates glucose-sensitive neurons in the hypothalamus

  • C. Reyes-Vazquez
  • V. Mendoza-Fernandez
  • M. Herrera-Ruiz
  • N. Dafny
RESEARCH ARTICLE

Abstract

 Interferon-α (IFN) therapy induces feeding suppression that resembles anorexia. The hypothalamic glucose-sensitive neurons engage in feeding behavior. Coronal sections of rat brains, containing both the lateral hypothalamus (LH) and the ventromedial hypothalamus (VMH), as well as single-cell recordings were used to study the interaction between IFN and glucose-sensitive neurons. IFN suppressed the majority (78%) of LH neurons, while reduction in glucose concentration elicited excitation in the majority (85%) of the same neurons. The opposite effects were observed in the VMH, where IFN excited the majority of neurons (61%), and reduction in glucose concentration exerted the opposite effects in 64% of VMH recordings. Concomitant IFN and glucose reduction exhibited only the effects elicited by IFN, regardless of whether the glucose reduction caused excitation (LH) or suppression (VMH). This observation suggests that IFN causes anorexia by modulating the LH and VMH glucose-sensitive neurons.

Key words Lateral hypothalamus Ventromedial hypothalamus Interferon Glucose Single cell Rat 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • C. Reyes-Vazquez
    • 1
  • V. Mendoza-Fernandez
    • 1
  • M. Herrera-Ruiz
    • 1
  • N. Dafny
    • 2
  1. 1.Departmentos de Farmacologia y Fisiologia, Facultad de Medicina, Universidad Nacional Autónoma de Mexico, Apartado Postal 70-250 Mexico, D.F. C.P. 04510MX
  2. 2.Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, P.O. Box 20708, Houston, TX 77225, USA Tel.: +1-713-500-5616, Fax: +1-713-500-5795US

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