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Cellular and Molecular Life Sciences CMLS

, Volume 58, Issue 10, pp 1522–1527 | Cite as

Geranylgeranylacetone protects human monocytes from mitochondrial membrane depolarization independently of Hsp70 expression

  • Y. Aron
  • M. Vayssier-Taussat
  • M. Bachelet
  • B.S. Polla

Abstract.

The anti-ulcer drug geranylgeranylacetone (GGA) has been shown to induce the expression of heat shock proteins (HSPs), in particular of Hsp70, in gastric and small intestine cells. In this study, we investigated whether GGA was able to induce Hsp70 in another cell type, human monocytes, which represent a well-established model of Hsp70 expression under oxidative stress. In these cells, GGA had no significant effect either on basal or tobacco smoke-induced Hsp70 expression. We further investigated the effects of GGA on mitochondria, a key organelle of oxidant-mediated cell injury and a putative target for GGA-mediated protection. GGA significantly increased basal mitochondrial membrane polarization and inhibited the decrease in mitochondrial membrane potential of human monocytes exposed to distinct sources of clinically relevent oxidants such as tobacco smoke and γ-irradiation. Our results indicate that mitochondria are targets for GGA-mediated protection against oxidative stress in human monocytes, independently of Hsp70.

Key words. Oxidative stress; protection; Hsp70; mitochondria; geranylgeranylacetone. 

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Copyright information

© Birkhäuser Verlag, 2001

Authors and Affiliations

  • Y. Aron
    • 1
  • M. Vayssier-Taussat
    • 1
  • M. Bachelet
    • 1
  • B.S. Polla
    • 1
  1. 1.Laboratoire de Physiologie Respiratoire, Groupe Hospitalier et Universitaire Cochin-Port Royal, Université Paris V, 24 rue du Faubourg Saint-Jacques, 75014 Paris (France)FR

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