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Cellular and Molecular Life Sciences CMLS

, Volume 57, Issue 13–14, pp 1978–1985 | Cite as

Lysophosphatidic acid: receptors, signaling and survival

  • J. T. Swarthout*
  • H. W. Walling

Abstract.

Though the mitogenic activity of lysophosphatidic acid (LPA) has been wellestablished through classical studies, its mechanism of action was long obscure. Recent identification and cloning of LPA-specific receptors has led to the elucidation of the G-proteins and signaling pathways through which this molecule functions. In addition to its mitogenic properties, recent reports have suggested that LPA may also promote cell survival. This review will summarize the current literature regarding LPA signaling and its role as an antiapoptotic factor.

Key words. G-protein-coupled receptors; apoptosis; mitogen; calcium mobilization; smooth muscle contraction; phosphatidylinositol. 

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Copyright information

© Birkhäuser Verlag Basel, 2000

Authors and Affiliations

  • J. T. Swarthout*
    • 1
  • H. W. Walling
    • 1
  1. 1.Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 S. Grand Blvd., St. Louis (Missouri 63104, USA), Fax 314 577 8233, e-mail: swarthjt@slu.edu US

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