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Lysophosphatidic acid: receptors, signaling and survival

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Abstract.

Though the mitogenic activity of lysophosphatidic acid (LPA) has been wellestablished through classical studies, its mechanism of action was long obscure. Recent identification and cloning of LPA-specific receptors has led to the elucidation of the G-proteins and signaling pathways through which this molecule functions. In addition to its mitogenic properties, recent reports have suggested that LPA may also promote cell survival. This review will summarize the current literature regarding LPA signaling and its role as an antiapoptotic factor.

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Authors and Affiliations

  1. Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 S. Grand Blvd., St. Louis (Missouri 63104, USA), Fax 314 577 8233, e-mail: swarthjt@slu.edu , , , , , , US

    J. T. Swarthout* & H. W. Walling

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  1. J. T. Swarthout*
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  2. H. W. Walling
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Received 13 March 2000; revised 25 April 2000; accepted 25 April 2000

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Swarthout*, J., Walling, H. Lysophosphatidic acid: receptors, signaling and survival . CMLS, Cell. Mol. Life Sci. 57, 1978–1985 (2000). https://doi.org/10.1007/PL00000678

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  • DOI: https://doi.org/10.1007/PL00000678

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