Advertisement

Journal of Hydrodynamics

, Volume 18, Issue 1, pp 246–251 | Cite as

Numerical simulation of pulsatile blood flow through asymmetric arterial stenoses under EECP

  • Jian-hang Du
  • Chun-liang Wu
  • Zhen-sheng Zheng
  • Gang Dai
Session A4

Abstract

In this paper, a three-dimensional model of pulsatile blood flow througth a vessel with an asymmetric stenosis is developed to numerically study the hemodynamics circumstance under EECP (Enhanced External Counter Pulsation). The governing equations are the usual Navier-Stokes equations for unsteady elliptic flows, and are numerically solved by using finite volume method. The numerical computing is based on the animal experiment. The blood flow rate curves in a cadiac cycle pre-EECP and post-EECP are detected in a pig’s carotid respectively, the counterpulsation pressure is 0.03MPa. The blood flow rate curves are transformed to blood velocity distributions along the arterial diameter by using the Womersley arithmetic. And the Womersley velocity profiles are used as inflow boundary conditions to simulate the whole hemodynamics circumstance inside the 3-dimensional artery model. The computational results show that when EECP is applied, the blood flow rate and the wall shear stress level of the artery are increased in a cadiac cycle, as well as the pulsatile character of blood flow and wall shear stress. Which are possibly the hemodynamic actors that lead to the improving of the endothelial function which is thought to be straightly relating to the atherosclerosis.

Key words

hemodynamics EECP (enhanced external counterpulsation) arterial stenosis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    Texon, M. Hemodynamics basis of atherosclerosis with critique of the cholesterol—heart disease hypothesis, 2th Edition. Begell House Publishers, 1996, New York.Google Scholar
  2. [2]
    Charles A. Taylor, Thomas J.R. Hughes, Christopher K. Zarins. Finite element modeling of blood flow in arteries. Comput. Methods Appl. Mech. Engrg. 1998, 158: 155–196.MathSciNetCrossRefGoogle Scholar
  3. [3]
    Du Jian-Hang, Bao Yun, Jin Ya-Fei. Study on intro-arterial hemodynamics environment under EECP with different couterpulsation pressure. Chinese Journal of Biomedical Engineering. 2005, 24(5): 620–624Google Scholar
  4. [4]
    Liu Qiong, Zheng Zhen-Sheng, Zhan Cheng-Yang. The relationship between hemodynamics and c-sis mRNA of EC. [J] Med Biol Eng Comput. 1997, 35(1): S147–7Google Scholar
  5. [5]
    Jin Ya-Fei, Zheng Zhen-Sheng, et al. The influence of EECP chronic experiment to the generation of atherosclerosis plaque in high-fat raised pigs. J Interventional Radiology. 2003, Vol 12, Sub, pp: 139–139.Google Scholar
  6. [6]
    K. C. Ang and J. N. Mazumdar. Mathematical Modelling of Three-Dimensional Flow through an Asymmetric Arterial Stenosis. Mathl. Comput. Modelling. 1997, 25(1): 19–29.CrossRefGoogle Scholar
  7. [7]
    Perktold K, Hofer M, et al. Validated computation of physiologic flow in a realistic coronary artery branch. Journal of Biomechanics. 31(1998) 217–228.CrossRefGoogle Scholar
  8. [8]
    Caro, C. G., Fitz-Gerald, J.M. and Schroter, R. C. Aheroma and arterial wall shear: observation, correlation and proposal of a shear dependent mass transfer mechanism of atherogenesis. Proc. Roy. Soc. Lond. 1971, 177, 109–159.CrossRefGoogle Scholar
  9. [9]
    Caro, C. G. and Parker, K. H. The effect of hemodynamics factors on the arterial wall. Atherosclerosis-Biology and clinical Science (Edited by Olsson, A. G.). 1987, PP: 183–195. Churchill Livingstone, Edinburgh.Google Scholar
  10. [10]
    Perktold, K and Rappisch, G. Computer simulation of local blood flow and vessel mechanics in a compliant carotid artery bifurcation model. J. Biomechanics. 1995, 28(7): 845–856.CrossRefGoogle Scholar
  11. [11]
    Du Jian-Hang, Yu Zhi, Bao Yun, Jin Ya-Fei. Numerical simulation of pulastile flow through a partial arterial stenosis. Journal of Hydrodynamics. 2006, 21(1): 1–7Google Scholar

Copyright information

© China Ship Scientific Research Center 2006

Authors and Affiliations

  • Jian-hang Du
    • 1
  • Chun-liang Wu
    • 1
  • Zhen-sheng Zheng
    • 2
  • Gang Dai
    • 2
  1. 1.Department of EngineeringGuangdong Ocean universityZhanjiangChina
  2. 2.Key Lab. On Assisted CirculationMinistry of HealthGuangzhouChina

Personalised recommendations