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Allergo Journal

, Volume 19, Issue 3, pp 178–179 | Cite as

Wird die Protektion gegen Allergien bereits im Mutterleib angelegt?

Erste Ergebnisse der Geburtskohortenstudie PASTURE (Protection against Allergy-Study in Rural Environments)
  • Petra Ina Pfefferle
  • Erika von Mutius
  • Harald Renz
  • PASTURE Study Group
Kurzbeitrag / Short Communication
  • 19 Downloads

Schlüsselwörter

Allergie Bauernhofeffekt Geburtskohortenstudie 

Does protection against allergies already start in utero?

First results of the ongoing birth cohort study PASTURE (Protection against Allergy-Study in Rural Environments)

Summary

Background

Traditional farming represents a unique model situation to investigate the relationship of early-life farm-related exposure and allergy protection. The aim of PASTURE (Protection against Allergy-Study in Rural Environments) was to investigate associations between maternal farm exposures and cytokine production in cord blood (CB) mononuclear cells in a prospective multinational birth cohort of 299 farm and 326 nonfarm children and their families.

Methods

Supernatants from PMA(phorbol myristate acetate)/ionomycin-stimulated CB mononuclear cells were assessed for the production of interferon(IFN)-γ, tumor necrosis factor(TNF)-α, interleukin(IL)-5, IL-10, and IL-12.

Results

Significantly higher levels of IFN-γ and TNF-α in farm compared with nonfarm children were found, whereas IL-5, IL-10, and IL-12 levels did not differ between study groups. Maternal contact with different farm animal species and barns and consumption of farm-produced butter during pregnancy enhanced the production of pro-inflammatory CB cytokines, whereas maternal consumption of farm-produced yogurt resulted in significantly lower levels of IFN-γ and TNF-α in umbilical blood.

Conclusion

Maternal exposure to farming activities and farm dairy products during pregnancy modulated cytokine production patterns of offspring at birth.

Key words

Allergy farm effect birth cohort study 

Copyright information

© Springer Medizin 2010

Authors and Affiliations

  • Petra Ina Pfefferle
    • 1
  • Erika von Mutius
    • 2
  • Harald Renz
    • 1
  • PASTURE Study Group
  1. 1.Abteilung für Klinische Chemie und Molekulare DiagnostikUniversität MarburgMarburgDeutschland
  2. 2.von Haunersches KinderspitalLudwig-Maximilians-Universität MünchenMünchenDeutschland

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