A computing system for the clinical and experimental investigation of cerebrovascular reactivity

  • Peter Smielewski
  • Marek Czosnyka
  • Wojciech Zabolotny
  • Peter Kirkpatrick
  • Hugh Richards
  • John D. Pickard


We present a computing system for the recording and on-line analysis of analogue signals derived from bedside cerebrovascular monitors in different pathophysiological conditions. These include arterial blood pressure and oxygen saturation, end-tidal carbon dioxide concentration, cerebral blood flow velocities using transcranial Doppler ultrasonography, and concentration changes in cerebral oxy- and deoxyhaemoglobin from near infrared spectroscopy. Configuration and analysis adopts arithmetic expressions of different signal processing functions, various statistical properties for each signal, frequency spectrum analysis using fast Fourier transformation, and correlation/cross-correlation. The software offers off-line analysis of non-invasive tests of cerebrovascular reactivity. Several examples of clinical assessment of cerebrovascular reactivity are presented, including cerebral haemodynamic stress tests which employ carbon dioxide, acetazolamide, the breath holding test, leg cuff inflation and deflation, and transient carotid artery compression. Application within the experimental setting with induced haemorrhagic hypotension can also be used.

Key words

autoregulation cerebrovascular reactivity computer-aided diagnosis multimodality monitoring waveform analysis 


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Copyright information

© Martinus Nijhoff Publishers 1997

Authors and Affiliations

  • Peter Smielewski
    • 1
  • Marek Czosnyka
    • 1
  • Wojciech Zabolotny
    • 1
  • Peter Kirkpatrick
    • 1
  • Hugh Richards
    • 1
  • John D. Pickard
    • 1
  1. 1.MRC Cambridge Centre for Brain Repair and Academic Neurosurgical Unit, Addenbrooke’s HospitalUniversity of CambridgeCambridgeUK

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