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Bilateral carcinoma in situ of the testis and cystic fibrosis transmembrane conductance regulator (CFTR) mutation in an azoospermic patient with late-onset 21β-hydroxylase deficiency

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Abstract

Testicular cancer can impair spermatogenesis. In addition, chemotherapy or radiotherapy used for its treatment further damage testicular function mainly affecting highly proliferating germ cells. The multifaceted etiology of male infertility includes, among others, alterations of male reproductive tract differentiation such as monolateral or bilateral congenital absence of vas deferens and perturbations in adrenal steroid synthesis on a genetic basis such as 21β-hydroxylase deficiency. Herein, we report the case of a male patient with primary infertility, probably related to a combination of genetic and acquired factors with different expressions over time.

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Authors and Affiliations

  1. DiSEM, University of Genoa, Viale Benedetto XV 6, 16132, Genoa, Italy

    L. Foppiani MD, PhD (Cattedra di Endocrinologia), C. Cappi, M. Giusti & F. Minuto

  2. Laboratory of Human Genetics, Galliera Hospital, Genoa, Italy

    M. Baffico & P. De Cassan

  3. Genetic Analysis Division of Biochemistry Laboratory, Niguarda Ca’ Granda Hospital, Milan, Italy

    G. Lando, M. C. Patrosso & S. Penco

  4. Unit of Pathology, S.Corona Hospital, Pietra Ligure, Savona, Italy

    A. Vitali

Authors
  1. L. Foppiani MD, PhD
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  2. M. Baffico
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  3. G. Lando
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  4. C. Cappi
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  5. P. De Cassan
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  6. M. C. Patrosso
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  7. A. Vitali
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  8. S. Penco
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  9. M. Giusti
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  10. F. Minuto
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Corresponding author

Correspondence to L. Foppiani MD, PhD.

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Foppiani, L., Baffico, M., Lando, G. et al. Bilateral carcinoma in situ of the testis and cystic fibrosis transmembrane conductance regulator (CFTR) mutation in an azoospermic patient with late-onset 21β-hydroxylase deficiency. J Endocrinol Invest 27, 370–374 (2004). https://doi.org/10.1007/BF03351065

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  • DOI: https://doi.org/10.1007/BF03351065

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