Bilateral carcinoma in situ of the testis and cystic fibrosis transmembrane conductance regulator (CFTR) mutation in an azoospermic patient with late-onset 21β-hydroxylase deficiency
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Testicular cancer can impair spermatogenesis. In addition, chemotherapy or radiotherapy used for its treatment further damage testicular function mainly affecting highly proliferating germ cells. The multifaceted etiology of male infertility includes, among others, alterations of male reproductive tract differentiation such as monolateral or bilateral congenital absence of vas deferens and perturbations in adrenal steroid synthesis on a genetic basis such as 21β-hydroxylase deficiency. Herein, we report the case of a male patient with primary infertility, probably related to a combination of genetic and acquired factors with different expressions over time.
Key-wordsInfertility carcinoma in situ CFTR mutation, 21β-hydroxylase deficiency CYP21 mutation
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- 6.Sokol RZ. Infertility in men with cystic fibrosis. Curr Opin Pulm Med 2000, 17: 421–6.Google Scholar
- 10.Bonizzato A, Rolfini R, Cabrini G. Detection of cystic fibrosis mutations by reverse dot-blot hybridization. Eur J Lab Med 1999, 7: 117–22.Google Scholar
- 11.Daudin M, Bieth E, Bujan L, Massat G, Pontonnier F, Mieusset R. Congenital bilateral absence of the vas deferens: clinical characteristics, biological parameters, cystic fibrosis transmembrane conductance regulator gene mutations, and implications for genetic counsuelling. Fertil Steril 2000, 74: 1164–74.PubMedCrossRefGoogle Scholar
- 16.Adesokan A, Adegboyega PA, Cowan DF, Kocurek J, Neal DE. Testicular “tumor” of the adrenogenital syndrome: a case report of an unusual association with the myelolipoma and seminoma in cryptoorchidism. J Clin Endocrinol Metab 1997, 80: 2120–7.Google Scholar