Pituitary prolactin-secreting macroadenoma combined with bilateral breast cancer in a 45-year-old male
- 36 Downloads
We describe an unusual case of bilateral breast cancer synchronous with pituitary macroprolactinoma in a young male. Up to date, only very few of such cases have been described worldwide and to our knowledge this is the first one in which both breast cancer and pituitary macroadenoma have been found together at the time of presentation. A 45-year-old male was diagnosed as having a pituitary macroprolactinoma and bilateral breast cancer on the basis of hypogonadism (testosterone 2.9 pmol/l) with very high levels of prolactin (33,100 U/l), typical neuroradiologic finding of a pituitary macroadenoma, marked bilateral gynecomastia with mammographic pattern highly suspected for cancer and subsequent hystological confirmation. Bilateral mastectomy was performed and medical therapy with bromocriptine 10 mg/day was started. After 2-year follow-up the patient is disease-free. Hormonal, neuroradiological and oncological patterns are all negative or markedly improved. We stress the importance of prolactin for its possible biological effects on breast cancer induction or growth. Moreover in any case of hyperprolactinemia we suggest a mammographic examination and, in the case of breast cancer, at least a baseline hormonal profile.
Key-wordsProlactin pituitary macroadenoma bilateral breast cancer male breast cancer
Unable to display preview. Download preview PDF.
- 3.Giaume M., Calcina G.G., Briglia R. Carcinoma bilaterale della mammella maschile. Oncologia, Minerva Medica, 1986, 77: 989–993.Google Scholar
- 9.Hayward J. Hormones and human breast cancer. Springer Verlag, Berlin, 1970, p. 113.Google Scholar
- 11.Mioduszewski O., Woszarowski T., Gorski C. The influence of hormones on breast cancer in vitro in relation to the clinical course of the disease. In: Forrest A.P.M., Kunkler P.B. (Eds.), Prognostic factors in breast cancer. Livingstone, Edimburgh, 1968. p. 347.Google Scholar
- 15.Welsh C.W., Nagasawa H. Prolactin and murine mammary tumorigenesis. Cancer Res. 1977, 37: 951–963.Google Scholar
- 16.Reynolds C., Montone K.T., Powell C.M., Tomaszewski J.E., Clevenger C.V. Expression of prolactin and its receptor in human breast carcinoma. Epidemiology 1997, 138: 5555–5560.Google Scholar
- 23.Wennbo H., Gebre-Medhin M., Gritli-Linde A., Ohlsson C., Isaksson O.G., Tornell G. Activation of the prolactin receptor but not the growth hormone receptor is important for induction of mammary tumors in transgenic mice. J. Clin. Invest. 1997, 100: 2744–2751.PubMedCentralPubMedCrossRefGoogle Scholar
- 24.Barni S., Lissoni P., Brivio F., Fumagalli L., Merlini D., Cataldo M., Rovelli F., Tancini G. Serum levels of insulin-like growth factor-I in operable breast cancer in relation to the main prognostic variables and their perioperative changes in relation to those of prolactin. Tumori 1994, 80: 212–215.PubMedGoogle Scholar