Skip to main content
Log in

Determination of free thyroid hormones and their binding proteins in a patient with severe hyperthyroidism (thyroid storm?) and thyroid encephalopathy

  • Case Report
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

A patient with severe hyperthyroidism (thyroid storm?) and thyroid encephalopathy is described. During her illness only a slightly raised level of total thyroxine and a normal level of total triiodothyronine was found in contrast with very high levels of free thyroid hormones. Very low levels of thyroxine binding globulin, albumin and low levels of thyroxine binding prealbumin in contrast with nearly normal values of T3 resin uptake were observed. All parameters of thyroid function returned to normal after therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Brooks M.H., Waldstein S.S., Bronsky D., Sterling K. Serum triiodothyronine concentration in thyroid storm. J. Clin. Endocrinol. Metab. 144: 398, 1975.

    Google Scholar 

  2. Brooks M.H., Waldstein S.S. Free thyroxine concentrations in thyroid storm. Ann. Intern. Med. 93: 694, 1980.

    Article  CAS  PubMed  Google Scholar 

  3. Bourdoux P., Branders C., Delange F., Ermans A.M. Parenteral nutrition may interfere in thyrotropin screening for congenital hypothyroidism. Clin. Chem. 27: 1343, 1981.

    Google Scholar 

  4. Glinoer D., Fernandez M., Ermans A.M. Use of directthyroxine-binding globulin measurement in the evaluation of thyroid function. J. Endocrinol. Invest. 1: 329, 1978.

    CAS  PubMed  Google Scholar 

  5. Rodkey F.L. Direct spectrophotometric determination of albumin in the serum with bromocresolgreen. Clin. Chem. 11: 478, 1965.

    CAS  PubMed  Google Scholar 

  6. Swanson J.W., Kelly J.J., McCohaney W.M. Neurologic aspects of thyroid dysfunction. Mayo Clin. Proc. 56: 504, 1981.

    CAS  PubMed  Google Scholar 

  7. Gershengorn M.C., Glinoer D., Fox S.H., Robbins J. Thyroxine binding globulin synthesis by hepatocarcinoma cells in continuous culture: Effect of physiological concentrations of thyroxine. Biochem. Biophys. Res. Commun. 71: 76, 1976.

    Article  CAS  PubMed  Google Scholar 

  8. Glinoer D., Delange F., Fernandez-Deville M., Lagasse R., Ermans A.M. Relationship between direct measurement of free T4 and free T4 index calculated from TBG. In: Ekins R., Faglia G., Pennisi F., Pinchera A. (Eds.), Proceedings of the International Symposium of Free Hormones. Excerpta Medica, Amsterdam, 1979, p. 107.

    Google Scholar 

  9. Gregerman R.I., Davis P.J. Intrinsic physiologic variables and nonthyroidal illness. In: Werner S.C., Ingbar S.H. (eds.), The thyroid, a fundamental and clinical text, ed. 4. Harper and Row, Hagerstown, 1978, p. 233.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Colebunders, R., Bourdoux, P., Bekaert, J. et al. Determination of free thyroid hormones and their binding proteins in a patient with severe hyperthyroidism (thyroid storm?) and thyroid encephalopathy. J Endocrinol Invest 7, 379–381 (1984). https://doi.org/10.1007/BF03351020

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03351020

Key-words

Navigation