Journal of Endocrinological Investigation

, Volume 1, Issue 4, pp 359–361 | Cite as

Circulating prolactin and its response to TRH following administration of testosterone undecanoate in normal men

  • P. M. Kicovic
  • M. Luisi
  • F. Franchi
  • S. Krempl
Short Communication


To investigate the effect of orally administered testosterone undecanoate (TU) on circulating prolactin (PRL) and PRL response to TRH stimulation, 8 eugonadal male volunteers, aged 19–30, presenting with normal plasma levels of FSH, LH, testosterone (T), estradiol (E2) and PRL, were given 120 mg/day of TU for 6 days. Plasma PRL levels were measured daily during the pre-treatment phase (3 days), treatment phase (6 days) and post-treatment phase (3 days) by radioimmunoassay. The TRH Test (200 μg iv) was done on the 3rd day of the pretreatment phase and on the treatment phase. No signficant changes in circulating PRL levels or in PRL response to TRH stimulation were observed. Plasma T and E2 levels showed a slight, but not significant tendency to increase, while gonadotropin levels remained unchanged.


Testosterone undecanoate plasma PRL TRH test normal men 


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  1. 1.
    Franchi F., Luisi M., Kicovic P.M. Pilot clinical and radioimmunological evaluation of the effects of orally administered testosterone undecanoate in hypogonadal men. Proc. 1st Intern. Congr. Androl., Barcelona (1976), Intern. J. Androl., (Suppl.) 1, 1978 (in press).Google Scholar
  2. 2.
    Metelkov Z., Rocic B., Skrabalo Z. Treatment of hypogonadal male patients with oral testosterone undecanoate: preliminary communication. Proc. 1 st Intern. Congr. Androl., Barcelona (1976), Intern. J. Androl., (Suppl.) 1, 1978 (in press).Google Scholar
  3. 3.
    Franchimont P., Kicovic P.M., Mattei A., Roulier R. Effects of oral testosterone undecanoate in hypogonadal male patients. Acta Endocrinol. (Kbh) (Suppl) 212: 118, 1977.Google Scholar
  4. 4.
    Mies R., Krempl S. Effects of oral testosterone undecanoate on plasma hormones and clinical symptomatology in hypogonadal male patients Acta Endocrinol. (Kbh) (Suppl) 212: 119, 1977Google Scholar
  5. 5.
    Mies R., Kicovic P.M. Effects of testosterone undecanoate administration on LH ad FSH response during the LH-RH Test in healthy male volunteers. Andrologia 9(3): 233, 1977.PubMedCrossRefGoogle Scholar
  6. 6.
    Luisi M., Eliasson R., Kicovic P.M., Franchi F., Alicicco E. Hypothalamic-pituitary responsiveness to the clomiphene stimulation during a placebo controlled study of testosterone undecanoate therapy in normal men. Proc. Intern. Symp. Rec. Progr. Androl., L’Aquila (1977), Academic Press, London-New York, 1978 (in press).Google Scholar
  7. 7.
    Frantz A.G., Kleinberg D.L, Noel G.L Studies on prolactin in man. Recent Progr. Horm. Res. 28: 527, 1972.PubMedGoogle Scholar
  8. 8.
    Yen S.S.C., Ehara Y., Siler T.M. Augmentation of prolactin secretion by estrogen in hypogonadal women. J. Clin. Invest. 53: 652, 1974.PubMedCentralPubMedCrossRefGoogle Scholar
  9. 9.
    Franchimont P., Dourcy S., Legros J.J., Reuter A., Vrindts-Gevaert Y., v. Cauwenberge J.R., Remade P., Gaspard U., Colin C. Dosage de la prolactine dans les conditions normales et pathologiques. Ann. Endocrinol. (Paris), 37: 127, 1976.Google Scholar
  10. 10.
    Luisi M., Kicovic P.M., Franchi F. Effects of estradiol decanoate in ovariectomized women. J. Endocrinol. Invest 2: 101, 1978.CrossRefGoogle Scholar
  11. 11.
    Luisi M., Franchi F., Menchini G.F., Barletta D., Fassorra C, Ciardella F., Gagliardi G. Radioimmunoassay for plasma testosterone. Steroids Lipidis Res. 4: 213, 1973.Google Scholar
  12. 12.
    Ciardella F., Galli P., Sgrilli R., Franchi F., Catarsi A.L., Birindelli R., Luisi M. Radioimmunoassay for plasma prolactin in humans. Boll. Soc. Med. Chir. 4: 219, 1976.Google Scholar
  13. 13.
    Franchimont P., Demoulin A., Bourguignon J.P. Clinical use of LH-RH Test as a diagnostic tool. Horm. Res. 6: 177, 1975.PubMedCrossRefGoogle Scholar
  14. 14.
    Kicovic P.M., Franchi M., Krempl S., Luisi M. Correlation between circulating estradiol and PRL response to TRH in men. Vth ESCO, Venezia, 1978 (submitted for presentation).Google Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 1978

Authors and Affiliations

  • P. M. Kicovic
    • 1
  • M. Luisi
    • 2
  • F. Franchi
    • 2
  • S. Krempl
    • 1
  1. 1.Medical UnitScientific Development GroupOrganon, OssHolland
  2. 2.Endocrine Unit of C.N.R., 1st Medical ClinicUniversity HospitalPisaItaly

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