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Journal of Endocrinological Investigation

, Volume 27, Issue 1, pp 37–41 | Cite as

Serum interleukin-6 predicts cortisol release in acute stroke patients

  • A. Szczudlik
  • T. Dziedzic
  • S. Bartus
  • A. Slowik
  • A. Kieltyka
Original Article

Abstract

Altered hypothalamo-pituitary-adrenal axis was reported in stroke patients; however, mechanisms responsible for this phenomenon are barely understood. Acute cerebral ischemia triggers interleukin-6 (IL-6) release into blood. Circulating IL-6 can stimulate hypothalamo-pituitary-adrenal axis. The goal of our study was to assess a relationship between serum IL-6 and cortisol in acute ischemic stroke. Twenty two patients with ischemic stroke and 17 controls were included. Serum samples were collected on the 2nd day of stroke at 6:00, 10:00 18:00, 22:00 h and at the same time points in control group. Cytokines and cortisol levels were measured using ELISA method. Serum IL-6 and cortisol levels were higher in stroke patients than in controls. Cortisol displayed diurnal variations in both stroke patients and controls. In contrast with control subjects, serum IL-6 levels did not display diurnal variations in stroke patients. In stroke patients, but not in controls, IL-6 level correlated significantly with cortisol level and morning serum IL-6 level independently predicted evening/night cortisol level. In conclusion, brain ischemia could stimulate IL-6 release in blood and in this way modulate hypothalamo-pituitary-adrenal axis.

Key-words

Cortisol cytokines stroke cerebral ischemia 

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Copyright information

© Italian Society of Endocrinology (SIE) 2004

Authors and Affiliations

  • A. Szczudlik
    • 1
  • T. Dziedzic
    • 1
  • S. Bartus
    • 2
  • A. Slowik
    • 1
  • A. Kieltyka
    • 3
  1. 1.Department of NeurologyJagiellonian UniversityKrakowPoland
  2. 2.2nd Department of CardiologyJagiellonian UniversityKrakowPoland
  3. 3.Department of Epidemiology, Collegium MedicumJagiellonian UniversityKrakowPoland

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