Zusammenfassung
In der Monografie der IARC Working Group (2012) wird ein positiver Zusammenhang zwischen der kumulativen Exposition gegenüber kristallinem SiO2 und dem Lungenkrebsrisiko festgestellt. Die Schlussfolgerungen basieren auf einer Metaanalyse von Lacasse et al. (2009), in welcher 4 Kohorten-Studien und 6 Fall-Kontroll-Studien einbezogen wurden. Allerdings bestehen Limitationen in den einzelnen einbezogenen Arbeiten durch mögliche Fehler in der Expositionsmessung bzw. -schätzung und weil unterschiedlich einwirkende Confounder bei der Entstehung von Lungenkrebs nicht immer ausreichend berücksichtigt werden konnten.
Neure Studien, welche nicht in die Monografie eingeschlossen wurden, zeigen ein sehr heterogenes Bild bezüglich einer Dosis-Wirkungs-Beziehung von Quarzstaub und Lungenkrebs.
Für zukünftige Studien wäre es wünschenswert und wichtig, einheitliche bzw. vergleichbare internationale Mess-Standards einzuführen, um den Vergleich der Arbeiten in Bezug auf Dosis-Wirkungs-Beziehungen zu erleichtern.
Abstract
The IARC Working Group concluded in its monography from 2012 that there is a dosiseffect relationship for the exposition to silica dust and lung cancer. This conclusion was drawn mainly based on a meta-analysis (Lacasse et al. 2009) which included 4 cohort and 6 case-control studies, however with limitations due to heterogeneity in the exposition assessment methods used and inadequate consideration of potential confounders in the included studies.
More recent studies not included in the IARC monography yield an heterogeneous picture, with some works showing a dose-effect relationship and others less consistent.
For future studies there is a need to develop an international standard for exposition assessment in order to facilitate comparisons across studies.
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Baur, X., Velasco-Garrido, M. & Manuwald, U. Dosis-Wirkungs-Beziehung von Quarzstaub in Bezug auf den Lungenkrebs. Zbl Arbeitsmed 63, 190–200 (2013). https://doi.org/10.1007/BF03350846
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DOI: https://doi.org/10.1007/BF03350846