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Dosis-Wirkungs-Beziehung von Quarzstaub in Bezug auf den Lungenkrebs

  • Xaver Baur
  • Marcial Velasco-Garrido
  • Ulf Manuwald
Originalarbeit

Zusammenfassung

In der Monografie der IARC Working Group (2012) wird ein positiver Zusammenhang zwischen der kumulativen Exposition gegenüber kristallinem SiO2 und dem Lungenkrebsrisiko festgestellt. Die Schlussfolgerungen basieren auf einer Metaanalyse von Lacasse et al. (2009), in welcher 4 Kohorten-Studien und 6 Fall-Kontroll-Studien einbezogen wurden. Allerdings bestehen Limitationen in den einzelnen einbezogenen Arbeiten durch mögliche Fehler in der Expositionsmessung bzw. -schätzung und weil unterschiedlich einwirkende Confounder bei der Entstehung von Lungenkrebs nicht immer ausreichend berücksichtigt werden konnten.

Neure Studien, welche nicht in die Monografie eingeschlossen wurden, zeigen ein sehr heterogenes Bild bezüglich einer Dosis-Wirkungs-Beziehung von Quarzstaub und Lungenkrebs.

Für zukünftige Studien wäre es wünschenswert und wichtig, einheitliche bzw. vergleichbare internationale Mess-Standards einzuführen, um den Vergleich der Arbeiten in Bezug auf Dosis-Wirkungs-Beziehungen zu erleichtern.

Schlagwörter

Quarz kristalline Kieselsäure Lungenkrebs Silikose arbeitsbedingte Erkrankungen 

Dose-response-relationship of quartz dust and lung cancer

Abstract

The IARC Working Group concluded in its monography from 2012 that there is a dosiseffect relationship for the exposition to silica dust and lung cancer. This conclusion was drawn mainly based on a meta-analysis (Lacasse et al. 2009) which included 4 cohort and 6 case-control studies, however with limitations due to heterogeneity in the exposition assessment methods used and inadequate consideration of potential confounders in the included studies.

More recent studies not included in the IARC monography yield an heterogeneous picture, with some works showing a dose-effect relationship and others less consistent.

For future studies there is a need to develop an international standard for exposition assessment in order to facilitate comparisons across studies.

Key words

Quartz Silica dust Lung cancer silicosis occupational disease 

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Literatur

  1. Andersson L, Bryngelsson IL, Ngo Y, Ohlson CG, Westberg H (2012) Exposure assessment and modeling of quartz in Swedish iron foundries for a nested case-control study on lung cancer. J Occup Environ Hyg 9(2):110–119.PubMedCrossRefGoogle Scholar
  2. Ärztlicher Sachverständigenbeirat beim BMAS (2001) Wissenschaftliche Begründung: Lungenkrebs durch die Einwirkung von kristallinem Siliziumdiuxid (SiO2) bei nachgewiesener Quarzstaublungenerkrankung (Silikose oder Siliko-Tuberkulose) Bek. des BMA vom 1. August 2001 — IVa 4-45222-2106/4112. BArbBl (09):37–59.Google Scholar
  3. Attfield MD, Kuempel ED (2008) Mortality among U.S. underground coal miners: a 23-year follow-up. Am J Ind Med 51(4):231–245.PubMedCrossRefGoogle Scholar
  4. Axelson O (1978) Aspects on confounding in occupational health epidemiology. Scandinavian Journal of Work, Environment & Health 4(1):98–102.CrossRefGoogle Scholar
  5. Axelson O, Steenland K (1988) Indirect methods of assessing the effects of tobacco use in occupational studies. Am J Ind Med 13(1):105–118.PubMedCrossRefGoogle Scholar
  6. Bergdahl IA, Jonsson H, Eriksson K, Damber L, Jarvholm B (2010) Lung cancer and exposure to quartz and diesel exhaust in Swedish iron ore miners with concurrent exposure to radon. Occup Environ Med 67(8):513–518.PubMedCrossRefGoogle Scholar
  7. Boyle P (1997) Cancer, cigarette smoking and premature death in Europe: a review including the Recommendations of European Cancer Experts Consensus Meeting, Helsinki, October 1996. Lung Cancer 17(1):1–60.PubMedCrossRefGoogle Scholar
  8. Brown TP, Rushton L (2005) Mortality in the UK industrial silica sand industry: 2. A retrospective cohort study. Occup Environ Med 62(7):446–452.PubMedCentralPubMedCrossRefGoogle Scholar
  9. Brüske-Hohlfeld I, Mohner M, Pohlabeln H, Ahrens W, Bolm-Audorff U, Kreienbrock L, Kreuzer M, Jahn I, Wichmann HE, Jockel KH (2000) Occupational lung cancer risk for men in Germany: results from a pooled case-control study. Am J Epidemiol 151(4):384–395.PubMedCrossRefGoogle Scholar
  10. Bugge MD, Kjaerheim K, Foreland S, Eduard W, Kjuus H (2012) Lung cancer incidence among Norwegian silicon carbide industry workers: associations with particulate exposure factors. Occup Environ Med 69(8):527–533.PubMedCentralPubMedCrossRefGoogle Scholar
  11. Cassidy A, t Mannetje A, van Tongeren M, Field JK, Zaridze D, Szeszenia-Dabrowska N, Rudnai P, Lissowska J, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Fevotte J, Fletcher T, Brennan P, Boffetta P (2007) Occupational exposure to crystalline silica and risk of lung cancer: a multicenter case-control study in Europe. Epidemiology 18(1):36–43.PubMedCrossRefGoogle Scholar
  12. Checkoway H, Heyer NJ, Seixas NS, Welp EA, Demers PA, Hughes JM, Weill H (1997) Dose-response associations of silica with nonmalignant respiratory disease and lung cancer mortality in the diatomaceous earth industry. Am J Epidemiol 145(8):680–688.PubMedCrossRefGoogle Scholar
  13. Chen W, Bochmann F, Sun Y (2007) Effects of work related confounders on the association between silica exposure and lung cancer: a nested case-control study among Chinese miners and pottery workers. Int Arch Occup Environ Health 80(4):320–326.PubMedCrossRefGoogle Scholar
  14. Chen W, Liu Y, Wang H, Hnizdo E, Sun Y, Su L, Zhang X, Weng S, Bochmann F, Hearl FJ, Chen J, Wu T (2012) Long-term exposure to silica dust and risk of total and cause-specific mortality in Chinese workers: a cohort study. PLoS Med 9(4):e1001206.Google Scholar
  15. Cocco P, Rice CH, Chen JQ, McCawley MA, McLaughlin JK, Dosemeci M (2001) Lung cancer risk, silica exposure, and silicosis in Chinese mines and pottery factories: the modifying role of other workplace lung carcinogens. Am J Ind Med 40(6):674–682.PubMedCrossRefGoogle Scholar
  16. Dahmann D, Taeger D, Kappler M, Buchte S, Morfeld P, Bruning T, Pesch B (2008) Assessment of exposure in epidemiological studies: the example of silica dust. J Expo Sci Environ Epidemiol 18(5):452–461.PubMedCrossRefGoogle Scholar
  17. Deutsche Forschungsgemeinschaft (2012) MAK- und BAK-Werte-Liste 2012, vol Mitteilung 48. Wiley-VCH Verlag GmbH & Co.KGaA, WeinheimCrossRefGoogle Scholar
  18. Erren TC, Morfeld P, Glende CB, Piekarski C, Cocco P (2011) Meta-analyses of published epidemiological studies, 1979-2006, point to open causal questions in silica-silicosis-lung cancer research. Med Lav 102(4):321–335.PubMedGoogle Scholar
  19. Greim HH (1998) Gesundheitsschädliche Ar-beitsstoffe — Toxikologische Begründung von MAK-Werten (Sonderdruck) 27. Lieferung. Steinkohlenstaub. WILWEY-VCH MünchenGoogle Scholar
  20. Greim HH (1999) Gesundheitsschädliche Ar-beitsstoffe — Toxikologische Begründung von MAK-Werten (Sonderdruck) 29. Lieferung. Siliciumdioxid. WILWEY-VCH MünchenGoogle Scholar
  21. Hughes JM, Weill H, Rando RJ, Shi R, McDonald AD, McDonald JC (2001) Cohort mortality study of North American industrial sand workers. II. Case-referent analysis of lung cancer and silicosis deaths. Ann Occup Hyg 45(3):201–207.PubMedCrossRefGoogle Scholar
  22. IARC (1997) Monographs on the evaluation of the carcinogenic risk of chemicals to humans., vol 68. Silica, some silicates, coal dust and para-aramid fibrils. IARC Press., GenevaGoogle Scholar
  23. IARC Working Group (2012) IARC Monographs; Arsenic, Metal, Fibres and Dust; AReview of Human Cancerogens Volume 100 C. International Agency for Research on Cancer, LyonGoogle Scholar
  24. Kurihara N, Wada O (2004) Silicosis and smoking strongly increase lung cancer risk in silica-exposed workers. Ind Health 42(3):303–314.PubMedCrossRefGoogle Scholar
  25. Lacasse Y, Martin S, Gagne D, Lakhal L (2009) Dose-response meta-analysis of silica and lung cancer. Cancer Causes Control 20(6):925–933.PubMedCrossRefGoogle Scholar
  26. Lacasse Y, Martin S, Simard S, Desmeules M (2005) Meta-analysis of silicosis and lung cancer. Scand J Work Environ Health 31(6):450–458.Google Scholar
  27. Lakhal L, Lacasse Y (2009) Reply to: Dr. Peter Morfeld’s Letter to the Editor (Manuscript Number: CACO2009): „Comment on Lacasse Y, Martin S, Gagne D, Lakhal L (2009) Dose-response meta-analysis of silica and lung cancer. Cancer Causes and Control 20:1537–1538.CrossRefGoogle Scholar
  28. McDonald JC, McDonald AD, Hughes JM, Rando RJ, Weill H (2005) Mortality from lung and kidney disease in a cohort of North American industrial sand workers: an update. Ann Occup Hyg 49(5):367–373.PubMedCrossRefGoogle Scholar
  29. Morfeld P (2009) Comment on: Lacasse Y, Martin S, Gagne D, Lakhal L (2009) Dose-response meta-analysis of silica and lung cancer. Cancer Causes Control (e-published ahead of print) doi:10.1007/s10552-009-9296-0. Cancer Causes Control 20(8):1535–1536; author reply 1537–1538.PubMedCrossRefGoogle Scholar
  30. Morfeld P, Lampert K (2004) Staubexposition, Pneumokonioseentwicklung und Lungen-krebsmortalität: eine Längsschnittstudie an Steinkohlenbergleuten aus dem Saarbergbau. Abschlussbericht zum Forschungsvorhaben. Hauptverband der gewerblichen Berufsgenos-senschaftenGoogle Scholar
  31. Mundt KA, Birk T, Parsons W, Borsch-Galetke E, Siegmund K, Heavner K, Guldner K (2011) Respirable crystalline silica exposure-response evaluation of silicosis morbidity and lung cancer mortality in the German porcelain industry cohort. J Occup Environ Med 53(3):282–289.PubMedCrossRefGoogle Scholar
  32. Olsen GW, Andres KL, Johnson RA, Buehrer BD, Holen BM, Morey SZ, Logan PW, Hewett P (2012) Cohort mortality study of roofing granule mine and mill workers. Part II. Epidemiologic analysis, 1945–2004. J Occup Environ Hyg 9(4):257–268.Google Scholar
  33. Pelucchi C, Pira E, Piolatto G, Coggiola M, Carta P, La Vecchia C (2006) Occupational silica exposure and lung cancer risk: a review of epidemiological studies 1996–2005. Ann Oncol 17(7):1039–1050.PubMedCrossRefGoogle Scholar
  34. Preller L, van den Bosch LM, van den Brandt PA, Kauppinen T, Goldbohm A (2010) Occupational exposure to silica and lung cancer risk in the Netherlands. Occup Environ Med 67(10):657–663.PubMedCrossRefGoogle Scholar
  35. Pukkala E, Guo J, Kyyronen P, Lindbohm ML, Sallmen M, Kauppinen T (2005) National jobexposure matrix in analyses of census-based estimates of occupational cancer risk. Scand J Work Environ Health 31(2):97–107.PubMedCrossRefGoogle Scholar
  36. Smith AH, Lopipero PA, Barroga VR (1995) Meta-analysis of studies of lung cancer among silicotics. Epidemiology 6(6):617–624.PubMedCrossRefGoogle Scholar
  37. Steenland K, Mannetje A, Boffetta P, Stayner L, Attfield M, Chen J, Dosemeci M, DeKlerk N, Hnizdo E, Koskela R, Checkoway H (2001) Pooled exposure-response analyses and risk assessment for lung cancer in 10 cohorts of silica-exposed workers: an IARC multicentre study. Cancer Causes Control 12(9):773–784.PubMedCrossRefGoogle Scholar
  38. Steenland K, Sanderson W (2001) Lung cancer among industrial sand workers exposed to crystalline silica. Am J Epidemiol 153(7):695–703.PubMedCrossRefGoogle Scholar
  39. Traeger D, Krahn U, Wiethege T, Ickstadt K, Johnen G, Eisenmenger A, Wesch H, Pesch B, Bruning T (2008) A study on lung cancer mortality related to radon, quartz, and arsenic exposures in German uranium miners. J Toxicol Environ Health A 71(13–14):859–865.CrossRefGoogle Scholar
  40. Tsuda T, Babazono A, Yamamoto E, Mino Y, Matsuoka H (1997) A meta-analysis on the relationship between pneumoconiosis and lung cancer. J Occup Health 39:285–294.CrossRefGoogle Scholar
  41. Ulm K, Waschulzik B, Ehnes H, Guldner K, Thomasson B, Schwebig A, Nuss H (1999) Silica dust and lung cancer in the German stone, quarrying, and ceramics industries: results of a case-control study. Thorax 54(4):347–351.PubMedCentralPubMedCrossRefGoogle Scholar
  42. Vacek PM, Verma DK, Graham WG, Callas P W, Gibbs GW (2011) Mortality in Vermont granite workers and its association with silica exposure. Occup Environ Med 68(5):312–318.PubMedCentralPubMedCrossRefGoogle Scholar
  43. Westberg HB, Bellander T (2003) Epidemiological adaptation of quartz exposure modeling in Swedish aluminum foundries: nested case-control study on lung cancer. Appl Occup Environ Hyg 18(12):1006–1013.PubMedCrossRefGoogle Scholar
  44. Yu IT, Tse LA, Leung CC, Wong TW, Tam CM, Chan AC (2007) Lung cancer mortality among silicotic workers in Hong Kong—no evidence for a link. Ann Oncol 18(6):1056–1063.PubMedCrossRefGoogle Scholar
  45. Zhang H, Cai B (2003) The impact of tobacco on lung health in China. Respirology 8(1):17–21.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2013

Authors and Affiliations

  • Xaver Baur
    • 1
  • Marcial Velasco-Garrido
    • 2
  • Ulf Manuwald
    • 3
  1. 1.Institut für ArbeitsmedizinCharitè Universitätsmedizin BerlinBerlinGermany
  2. 2.Dept. of Occupational MedicineUniversity Medical Center Hamburg-EppendorfHamburgGermany
  3. 3.Institut für UmweltmedizinErfurtGermany

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