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Paracrine and autocrine functions of glomerular mesangial cells

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References

  1. Brenner B.M., Meyer T.W., Hostetter T.H. Dietary protein intake and progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N. Engl. J. Med. 307: 652, 1982.

    Article  PubMed  CAS  Google Scholar 

  2. Latta H. Ultrastructure of the glomerulus and iuxtaglomerular apparatus. In: Orloff J., Berliner R.W., Geiger S.R. (Eds.), Handbook of Physiology. Williams and Wilkins, Baltimore, 1973, p. 1.

    Google Scholar 

  3. Zimmermann K.W. Uber den Bau des Glomerulus der Saugerniere: Weitare Mitteilunger. Z. Mikrosk. Anat. Forsch. 32: 176, 1933.

    Google Scholar 

  4. Kreisberg J.I., Venkatachalam M., Troyer D. Contractile properties of cultured glomerular mesangial cells. Am. J. Physiol. 249 (Renal Fluid Electrolyte Physiol. 18): F457, 1985.

    PubMed  CAS  Google Scholar 

  5. Schlondorff D. The glomerular mesangial cell: an expanding role for a specialized pericyte. Faseb J. 1: 272, 1987.

    PubMed  CAS  Google Scholar 

  6. Menè P., Simonson M.S., Dunn M.J. Physiology of the mesangial cell. Physiol. Rev., (in press) 1989.

  7. Schreiner G.F., Unanue E.R. Origin of the rat mesangial phagocyte and its expression of the leukocyte common antigen. Lab. Invest. 51: 515, 1984.

    PubMed  CAS  Google Scholar 

  8. Striker G.E., Lange M.A., Mackay K., Bernstein K., Striker L.J. Glomerular cells in vitro. Adv. Nephrol. 16: 169, 1987.

    CAS  Google Scholar 

  9. Latta H., Fligiel S. Mesangial fenestrations, sieving, filtration, and flow. Lab. Invest. 52: 591, 1985.

    PubMed  CAS  Google Scholar 

  10. Brenner B.M., Dworkin L.D., Ichikawa I. Glomerular ultrafiltration. In: Brenner B.M., Rector F.C. (Eds.), The Kidney. W.B. Saunders, Philadelphia, 1986, p. 124.

  11. Striker G.E., Striker L.J. Glomerular cell culture. Lab. Invest. 53: 122, 1985.

    PubMed  CAS  Google Scholar 

  12. Abboud H.E., Poptic E., Di Corleto P. Production of platelet-derived growth factorlike protein by rat mesangial cells in culture. J. Clin. Invest. 80: 675, 1987.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  13. Shultz P., Di Corleto P.E., Silver B.J., Abboud H.E. Mesangial cells release a PDGF-like protein, express PDGF mRNAs and proliferate in response to PDGF. Am. J. Physiol. 255 (Renal, Fluid and Electrolyte Physiol. 24): F674, 1988.

    PubMed  CAS  Google Scholar 

  14. Abboud H.E., Silver B., Di Corleto P., Shultz P. Human mesangial cells in culture express the genes for the A chain and B chain (c-sis) of platelet-derived growth factor (PDGF): regulation by thrombin. Kidney Int. 33: 148, 1988 (Abstract).

    Google Scholar 

  15. Conti F.G., Striker L.J., Elliot S.J., Andreani D., Striker G.E. Synthesis and release of insulinlike growth factor I by mesangial cells in culture. Am. J. Physiol. 255 (Renal Fluid Electrolyte Physiol. 24): F1214, 1988.

    PubMed  CAS  Google Scholar 

  16. Lovett D.H., Szamel M., Ryan J.L., Sterzel R.B., Gemsa D., Resch K. Interleukin 1 and the glomerular mesangium. I. Purification and characterization of a mesangial cell-derived autogrowth factor. J. Immunol. 136: 3700, 1986.

    PubMed  CAS  Google Scholar 

  17. Werber H.I., Emancipator S.N., Tykocinski M.L., Sedor J.R. The interleukin 1 gene is expressed by rat glomerular mesangial cells and is augmented in immune complex glomerulonephritis. J. Immunol. 138: 3207, 1987.

    PubMed  CAS  Google Scholar 

  18. Lovett D.H., Larsen A. Cell cycle-dependent interleukin 1 gene expression by cultured glomerular mesangial cells. J. Clin. Invest. 82: 115, 1988.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  19. Kurtz A., Jelkmann W., Sinowatz F., Bauer C. Renal mesangial cells in culture in a model of erythropoietin production. Proc. Natl. Acad. Sci. USA 80: 4008, 1983.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  20. Kurtz A., Jelkmann W., Pfeilschifter J., Bauer C. Role of prostaglandins in hypoxia-stimulated erythropoietin production. Am.J. Physiol. 249 (Cell Physiol. 18): C3, 1985.

    PubMed  CAS  Google Scholar 

  21. Lacombe C., Dasilva J.L., Bruneval P., Fournier J.G., Wendung F., Casadevall N., Camilleri J.P., Bariety J., Varet B., Tambourin P. Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney. J. Clin. Invest. 81: 620, 1988.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  22. Sraer J., Foidart D., Chansel P., Mahieu P., Ardaillou R. Prostaglandin synthesis by rat isolated glomeruli and glomerular cultured cells. Int. J. Biochem. 12: 203, 1980.

    Article  PubMed  CAS  Google Scholar 

  23. Scharschmidt L.A., Dunn M.J. Prostaglandin synthesis by rat glomerular mesangial cells in culture. Effects of angiotensin II and arginine vasopressin. J. Clin. Invest. 71: 1756, 1983.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  24. Menè P., Simonson M.S., Dunn M.J. Phospholipids in signal transduction of mesangial cells. Am. J. Physiol. 256 (Renal Fluid Electrolyte Physiol. 25): F375, (in press) 1989.

    PubMed  Google Scholar 

  25. Pugliese F., Menè P., Anania M.C., Cinotti G.A. Neutralization of the anionic sites of cultured rat mesangial cells by poly-L-lysine. Kidney Int. 35: 817, 1989.

    Article  PubMed  CAS  Google Scholar 

  26. Baud L., Hagege J., Sraer J., Rondeau E., Perez J., Ardaillou R. Reactive oxygen production by cultured rat glomerular mesangial cells during phagocytosis is associated with stimulation of lipooxygenase activity. J. Exp. Med. 158: 1836, 1983.

    Article  PubMed  CAS  Google Scholar 

  27. Schlondorff D., Neuwirth R. Platelet-activating factor and the kidney. Am. J. Physiol. 251 (Renal Fluid Electrolyte Physiol 20): F1, 1986.

    PubMed  CAS  Google Scholar 

  28. Lianos E.A., Zanglis A. Biosynthesis and metabolism of 1-O-alkyl-2-acetylsn-glycero-3-phosphocholine in rat glomerular mesangial cells. J. Biol. Chem. 262: 8990, 1987.

    PubMed  CAS  Google Scholar 

  29. Wang J., Kester M., Dunn M.J. The effects of endotoxin on platelet activating factor synthesis in cultured rat glomerular mesangial cells. Biochim. Biophys. Acta 969: 217, 1988.

    Article  PubMed  CAS  Google Scholar 

  30. Schlondorff D., Satriano J.A., Hagege J., Perez J., Baud L. Effect of platelet activating factor and serum-treated zymosan on PGE2 synthesis, arachidonic acid release, and contraction of cultured rat mesangial cells. J. Clin. Invest. 73: 1227, 1984.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  31. Bertani T., Livio M., Macconi D., Morigi M., Bisogno G., Patrono C., Remuzzi G. Platelet activating factor (PAF) as a mediator of injury in nephrotoxic nephritis. Kidney Int. 31: 1248, 1987.

    Article  PubMed  CAS  Google Scholar 

  32. Dzau V.J., Kreisberg J.I. Cultured glomerular mesangial cells contain renin: influence of calcium and isoproterenol. J. Cardiovasc. Pharmacol. 8(Suppl. 10): S6, 1986.

    Article  PubMed  CAS  Google Scholar 

  33. Chansel D., Dussaule J.C., Ardaillou N., Ardaillou R. Identification and regulation of renin in human cultured mesangial cells. Am. J. Physiol. 252 (Renal Fluid Electrolyte Physiol. 21): F32, 1987.

    PubMed  CAS  Google Scholar 

  34. Patrono C., Pugliese F., Ciabattoni G., Maseri A., Chierchia S., Peskar B.A., Cinotti G.A., Simonetti B.M., Pierucci A. Evidence for a direct stimulatory effect of prostacyclin on renin release in man. J. Clin. Invest. 69: 231, 1982.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  35. Lovett D.H., Sterzel R.B., Kashgarian M., Ryan J.L Neutral proteinase activity produced in vitro by cells of the glomerular mesangium. Kidney Int. 23: 342, 1983.

    Article  PubMed  CAS  Google Scholar 

  36. Berridge M.J. Inositol trisphosphate and diacylglycerol as second messengers. Biochem. J. 220: 345, 1984.

    PubMed Central  PubMed  CAS  Google Scholar 

  37. Pfeilschifter J., Kurtz A., Bauer C. Activation of phospholipase C and prostaglandin synthesis by [arginine] vasopressin in cultures. Biochem J. 223: 856, 1984.

    Google Scholar 

  38. Nishizuka Y. Studies and perspectives of protein kinase C. Science, 233: 305, 1986.

    Article  PubMed  CAS  Google Scholar 

  39. Ganz M.B., Boyarski G., Boron W.F., Sterzel R.B. Effects of angiotensin II and vasopressin on intracellular pH of glomerular mesangial cells. Am. J. Physiol. 254 (Renal Fluid Electrolyte Physiol. 23): F787, 1988.

    PubMed  CAS  Google Scholar 

  40. Besterman J.M., Duronio V., Cuatrecasas P. Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger. Proc. Natl. Acad. Sci. USA 83: 6785, 1986.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  41. Kester M., Simonson M.S., Menè P., Sedor J.R. Interleukin-1 generates transmembrane signals from phospholipids through novel pathways. J. Clin. Invest., 83: 718, 1989.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  42. Schlondorff D., De Candido S., Satriano J.A. Angiotensin II stimulates phospholipases C and A2 in cultured rat mesangial cells. Am. J. Physiol. 253 (Cell Physiol.): C113, 1987.

    PubMed  CAS  Google Scholar 

  43. Bonventre J.V., Weber P.C., Gronich J. PAF and PDGF increase cytosolic [Ca2+] and phospholipase activity in mesangial cells. Am. J. Physiol. 254 (Renal Fluid Electrolyte Physiol. 23): F87, 1988.

    PubMed  CAS  Google Scholar 

  44. Kester M., Wang J., Orehek J., Menè P., Dunn M.J. Evidence for multiple signaling pathways for plateletactivating factor in cultured rat mesangial cells. Kidney Int. 33: 161, 1988 (Abstract).

    Google Scholar 

  45. Gronich J.H., Bonventre J.V., Nemenoff R.A. Identification and characterization of a hormonally regulated form of phospholipase A2 in rat renal mesangial cells. J. Biol. Chem. 263: 16645, 1988.

    PubMed  CAS  Google Scholar 

  46. Menè P., Dunn M.J. Eicosanoids and control of mesangial cell contraction. Circ. Res. 62: 916, 1988.

    Article  PubMed  Google Scholar 

  47. Menè P., Dubyak G.R., Abboud H.E., Scarpa A., Dunn M.J. Phospholipase C activation by prostaglandins and thromboxane A2 in cultured mesangial cells. Am. J. Physiol. 255 (Renal Fluid Electrolyte Physiol. 24): F1059, 1988.

    PubMed  Google Scholar 

  48. Foidart J.B., Mahieu P. Glomerular mesangial cell contractility is controlled by an angiotensin-prostaglandin balance. Mol. Cell. Endocrinol. 47: 163, 1986.

    Article  PubMed  CAS  Google Scholar 

  49. Menè P., Dunn M.J. Contractile effects of TxA2 and endoperoxide analogues on cultured rat glomerular mesangial cells. Am. J. Physiol. 251 (Renal Fluid Electrolyte Physiol. 20): F1029, 1986.

    PubMed  Google Scholar 

  50. Homma T., Ichikawa I., Hoover R.L. Prostaglandins of mesangium origin inhibit mesangial cell (MC) proliferation and matrix synthesis. Kidney Int. 33: 268, 1988 (Abstract).

    Google Scholar 

  51. Menè P., Mc Dermott R.G., Dunn M.J. Modulation of mesangial cell proliferation by prostaglandins. Kidney Int. 33: 276, 1988 (Abstract).

    Google Scholar 

  52. Barnett R., Singhai P.C., Scharschmidt L.A., Schlondorff D. Dopamine attenuates the contractile response to angiotensin II in isolated rat glomeruli and cultured mesangial cells. Circ. Res. 59: 529, 1986.

    Article  PubMed  CAS  Google Scholar 

  53. Appel R.G., Wang J., Simonson M.S., Dunn M.J. A mechanism by which atrial natriuretic factors mediates its glomerular actions. Am. J. Physiol 251 (Renal Fluid Electrolyte Physiol. 20): F1036, 1986.

    PubMed  CAS  Google Scholar 

  54. Abboud H.E., Throckmorton D., Weinshell E., Jaffer F. Differential modulation of mesangial cell proliferation by peptide growth factors and cyclic adenosine monophosphate (cAMP). Faseb J. 2: A627, 1988 (Abstract).

    Google Scholar 

  55. Joyce N.C., Decamilli P., Lohmann S.M., Walter U. cGMP-dependent protein kinase is present in high concentrations in contractile cells of the kidney vasculature. J. Cyclic Nucleotide Protein Phosphor. Res. 11: 191, 1986.

    PubMed  CAS  Google Scholar 

  56. Shultz P., Hartich L., Raij L. The endothelium-derived relaxing factor nitric oxide increases cGMP levels in rat mesangial cells. Clin. Res. 36: 526A, 1988.

    Google Scholar 

  57. Simonson M.S., Wann S., Menè P., Dubyak G.R., Kester M., Nakazato Y., Sedor J.R., Dunn M.J. Endothelin stimulates phospholipase C., Na+/H+ exchange, c-fos expression and mitogenesis in rat mesangial cells. J. Clin. Invest., 83: 708, 1989.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  58. Lovett D.H., Martin M., Bursten S., Szamel M., Gemsa D., Resch K. Interleukin 1 and the glomerular mesangium. III. IL-1-dependent stimulation of mesangial cell protein kinase activity. Kidney Int. 34: 26, 1988.

    Article  PubMed  CAS  Google Scholar 

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  1. Cattedra di Nefrologia Medica, 2a Clinica Medica, Policlinico Umberto I, Università degli Studi “La Sapienza” di Roma, Viale del Policlinico, 00161, Rome, Italy

    P. Menè M.D. & G. A. Cinotti

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Menè, P., Cinotti, G.A. Paracrine and autocrine functions of glomerular mesangial cells. J Endocrinol Invest 12, 497–509 (1989). https://doi.org/10.1007/BF03350746

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