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Journal of Endocrinological Investigation

, Volume 5, Issue 1, pp 53–55 | Cite as

Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man

  • A. Masala
  • S. Magna
  • L. Devilla
  • P. P. Rovasio
  • S. Rassu
  • R. Faedda
  • A. Satta
Short Communication

Abstract

The effect of pirenzepine, a muscarinic receptor blocker which does not cross the blood brain barrier, on basal and TRH-stimulated prolactin (PRL) secretion in normal subjects was studied. Administration of 75 mg oral pirenzepine had no effects on prolactin levels in male subjects whereas it significantly reduced prolactin in females. No effect on TRH induced prolactin secretion was observed.

Key words

muscarinic receptors pirenzepine prolactin 

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Copyright information

© Italian Society of Endocrinology (SIE) 1982

Authors and Affiliations

  • A. Masala
    • 1
  • S. Magna
    • 1
  • L. Devilla
    • 2
  • P. P. Rovasio
    • 1
  • S. Rassu
    • 1
  • R. Faedda
    • 2
  • A. Satta
    • 2
  1. 1.Istituto di Patologia Medica IUniversità di SassariSassariItaly
  2. 2.Cattedra di Semeiotica Medica RUniversità di GenovaGenovaItaly

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