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Regulation of thyroid-stimulating hormone (TSH) secretion in the fetus and neonate1

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References

  1. Larsen P.R. Thyroid-pituitary interaction. Feedback regulation of thyrotropin secretion by thyroid hormones. N. Engl. J. Med. 306: 23, 1982.

    Article  PubMed  CAS  Google Scholar 

  2. Burger H.G., Patel Y.C. TSH and TRH: their physiological regulation and clinical application of TRH. In: Martini L., Besser G.M. (Eds.). Clinical Neuroendocrinology. Academic Press, New York, 1977, p. 67.

    Chapter  Google Scholar 

  3. Scanion M.F., Pourmand M., McGregor A.M., Rodriguez-Arnao M.D., Hall K., Gomez-Pan A., Hall R. Some current aspects of clinical and experimental neuroendocrinology with particular reference to growth hormone, thyrotropin and prolactin. J. Endocrinol. Invest. 2: 307, 1979.

    Article  Google Scholar 

  4. Morley J.E. Neuroendocrine control of thyrotropin secretion. Endocr. Rev. 2: 396, 1981.

    Article  PubMed  CAS  Google Scholar 

  5. Peters J.R., Foord S.M., Dieguez C., Scanion M.F. TSH neuroregulation and alterations in disease states. Clin. Endocrinol. Metab. 12: 669, 1983.

    Article  PubMed  CAS  Google Scholar 

  6. Kaplan S.L., Grumbach M.M., Aubert M.L. The ontogenesis of pituitary hormones and hypothalamic factors in the human fetus: maturation of central nervous system; regulation of anterior pituitary function. Recent Prog. Horm. Res. 32: 161, 1976.

    PubMed  CAS  Google Scholar 

  7. Gluckman P.D., Grumbach M.M., Kaplan S.L. The neuroendocrine regulation and function of growth hormone and prolactin in the mammalian fetus. Endocr. Rev. 2: 363, 1981.

    Article  PubMed  CAS  Google Scholar 

  8. Fisher D.A., Klein A.H. Thyroid development and disorders of thyroid function in the newborn. N. Engl. J. Med. 304: 702, 1981.

    Article  PubMed  CAS  Google Scholar 

  9. Thliveris J.A., Currie R.W. Observations on the hypothalamus-hypophyseal portal vasculature in the developing human fetus. Am. J. Anat. 157: 441, 1980.

    Article  PubMed  CAS  Google Scholar 

  10. Fisher D.A., Dussault J.H., Sack J., Chopra I.J. Ontogenesis of hypothalamic-pituitary-thyroid function and metabolism in man, sheep, and rat. Recent Prog. Horm. Res. 33: 59, 1977.

    Google Scholar 

  11. Falin F.I. The development of human hypophysis and differentiation of cells of its anterior lobe during embryonic life. Acta Anat. 44: 188, 1961.

    Article  PubMed  CAS  Google Scholar 

  12. Conklin J.L The development of the human fetal adenohypophysis. Anat. Rec. 160: 79, 1968.

    Article  PubMed  CAS  Google Scholar 

  13. Baker B.L., Jaffe R.B. The genesis of cell types in the adenohypophysis of the human fetus as observed with immunocytochemistry. Am. J. Anat. 143: 137, 1975.

    Article  PubMed  CAS  Google Scholar 

  14. Dubois P.M., Begeot M. Immunocytological localization of LH, FSH, TSH and their subunits in the pituitary of normal and anencephalic human fetuses. Cell Tissue Res. 191: 249, 1978.

    Article  PubMed  CAS  Google Scholar 

  15. Hatakeyama S. Electron microscopic study of the anencephalic adenohypophysis with reference to the adrenocorticotrophs and their correlation with the functional differentiation of the hypothalamus during the foetal life. Endocrinol. (Jpn.) 16: 187, 1969.

    Article  CAS  Google Scholar 

  16. Fukuchi M., Inove J., Abe H., Kumahara Y. Thyrotropin in human fetal pituitaries. J. Clin. Endocrinol. Metab. 31: 565, 1970.

    Article  PubMed  CAS  Google Scholar 

  17. Bugnon C., Block B., Fellman D. Etudes cyto-immunologiques des cellules gonadotropes des foetus humain. Bull. Assoc. Anat. 60: 259, 1976.

    CAS  Google Scholar 

  18. Fisher D.A., Hobel C.J., Garza R., Pierce C.A. Thyroid function in the preterm fetus. Pediatrics 40: 208, 1970.

    Google Scholar 

  19. Roti E., Benassi L., Bandini P., Robuschi G., Alfieri L., Gnudi A. Thyroid hormone levels in cord serum from at term, premature and small for gestational age newborns. In: Salvadori B., Bacchi-Modena A. (Eds.)., Poor intrauterine fetal growth. Edizioni Minerva Medica, Parma, 1977, p. 593.

    Google Scholar 

  20. Fisher D.A., Odell W.D., Hobel C.J., Garza R. Thyroid function in the term fetus. Pediatrics 44: 526, 1969.

    PubMed  CAS  Google Scholar 

  21. Roti E., Robuschi G., Emanuele R., Benassi L., Bandini P., Russo A., Gnudi A. Concentrazioni di tiroxina, triiodotironina, reverse T3, tireotropo e tireoglobulina nel sangue del cordone ed in quello materno. Minerva Pediatr. 33: 843, 1981.

    PubMed  CAS  Google Scholar 

  22. Chopra I.J., Crandall B.F. Thyroid hormones and thyrotropin in amniotic fluid. N. Engl. J. Med. 293: 740, 1975.

    Article  PubMed  CAS  Google Scholar 

  23. Roti E., Malavasi F., Bandini P., Robuschi G., Benassi L., Gnudi A. 3, 3′, 5′-triiodothyronine concentrations in amniotic fluid at different ages of pregnancy. J. Endocrinol. Invest. 2: 213, 1979.

    Article  PubMed  CAS  Google Scholar 

  24. Kourides I.A., Heath C., Ginsberg-Fellner F. Measurement of thyroid stimulating hormone in human amniotic fluid. J. Clin. Endocrinol. Metab. 54: 635, 1982.

    Article  PubMed  CAS  Google Scholar 

  25. Hollingsworth D.R., Alexander N.M. Amniotic fluid concentrations of iodothyronines and thyrotropin do not reliably predict fetal thyroid status in pregnancies complicated by maternal thyroid disorders or anencephaly. J. Clin. Endocrinol. Metab. 57: 349, 1983.

    Article  PubMed  CAS  Google Scholar 

  26. Yoshida K., Sakurada T., Takahashi T., Furuhashi N., Kaise K., Yoshinaga K. Measurement of TSH in human amnioticfluid: diagnosis of fetal thyroid abnormality in utero. Clin. Endocrinol. (Oxf.) 25: 313, 1986.

    Article  CAS  Google Scholar 

  27. Robuschi G., Braverman L.E., Emanuele R., d’Amato L., Gardini E., Foscolo M.S., Gualerzi C., Benassi L., Gnudi A., Roti E. Amniotic fluid thyrotropin (TSH) does not reflect elevated fetal serum TSH following maternal administration of thyrotropin releasing hormone. J. Perinat. Med. 13: 219, 1985.

    Article  PubMed  CAS  Google Scholar 

  28. Kourides I.A., Berkowitz R.L., Pang S., Van Natta F.C., Barone C.M., Ginsberg-Fellner F. Antepartum diagnosis of goitrous hypothyroidism by fetal ultrasonography and amniotic fluid thyrotropin concentration. J. Clin. Endocrinol. Metab. 59: 1016, 1984.

    Article  PubMed  CAS  Google Scholar 

  29. Fisher D.A. The unique endocrine milieu of the fetus. J. Clin. Invest. 78: 603, 1986.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  30. Christianson D., Roti E., Vagenakis A., Braverman L.E. The sex-related difference in serum thyrotropin concentration is androgen mediated. Endocrinology 108: 529, 1981.

    Article  PubMed  CAS  Google Scholar 

  31. Kieffer J.D., Mover H., Federico P., Maalof F. Pituitary-thyroid axis in neonatal and adult rats: comparison of the sexes. Endocrinology 98: 295, 1976.

    Article  PubMed  CAS  Google Scholar 

  32. Roti E., Gnudi A., Robuschi G., Bandini P., Alfieri A., Benassi L. Ormoni tiroidei nel sangue del funicolo ombelicale: rapporti coi livelli materni, età gestazionale e peso corporeo del neonato. In: Giornate Endocrinologiche Pisane. Pacini Editore, Pisa, 1977, p. 991.

  33. Pacini F., Lari R., La Ricca P., Grasso L., Taddei D., Bardini N., Fenzi G.F., Di Bartolo F., Baschieri L., Pinchera A. Serum thyroglobulin in newborns’cord blood in childood and adolescence: a physiological indicator of thyroid status. J. Endocrinol. Invest. 7: 467, 1984.

    Article  PubMed  CAS  Google Scholar 

  34. Hirano T., Singh J., Srinivasan G., Pildes R. Post-natal thyroid function in low birth weight infants; a longitudinal assessment of free thyroxine and thyroid hormone binding globulin. Acta Endocrinol. (Kbh.) 110: 56, 1985.

    CAS  Google Scholar 

  35. Penny R., Spencer C.A., Frasier S.D., Nicoloff J.T. Cord serum thyroid stimulating hormone and thyroglobulin levels decline with increasing birth weight in newborns. J. Clin. Endocrinol. Metab. 59: 979, 1984.

    Article  PubMed  CAS  Google Scholar 

  36. Villena A., Pretell E.A., Manucci E., Wong E. Perinatal pituitary thyroid function at high altitude. In: Medeiros-Neto G., Gaitan E. (Eds.), Frontiers in thyroidology. Plenum Medical Book Company, New York, 1986, vol. 1, p. 243.

    Chapter  Google Scholar 

  37. Rogowski P., Siesbaek-Nielsen K., Hansen J.M. Seasonal variation in neonatal thyroid function. J. Clin. Endocrinol. Metab. 39: 919, 1974.

    Article  PubMed  CAS  Google Scholar 

  38. Fisher D.A., Odell W.D. Acute release of thyrotropin in the newborn. J. Clin. Invest. 48: 1670, 1969.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  39. Czemichow P., Greenberg A.H., Tyson J., Blizzard R. Thyroid function studied in paired maternal cord sera and subsequential observations of thyrotropic hormone release during the first 72 hours of life. Pediatr. Res. 5: 53, 1971.

    Article  Google Scholar 

  40. Jacobsen B.B., Andersen H.J., Peitersen B., Dige-Petersen H., Hummer L. Serum levels of thyrotropin, thyroxine and triiodothyronine in full-term, small-for-gestational age and preterm newborn babies. Acta Paediatr. Scand. 66: 681, 1977.

    Article  PubMed  CAS  Google Scholar 

  41. Klein A.H., Foley B., Kenny F.M., Fisher D.A. Thyroid hormone and thyrotropin responses to parturition in premature infants with and without the respiratory distress syndrome. Pediatrics 63: 380, 1970.

    Google Scholar 

  42. Sack J., Fisher D.A., Wang C.C. Serum thyrotropin, prolactin and growth hormone levels during the early neonatal period in human infant. J. Pediatr. 89: 298, 1976.

    Article  PubMed  CAS  Google Scholar 

  43. Oddie T.H., Bernard B., Presley M., Klein A.H., Fisher D.A. Damped oscillations in serum thyroid hormone levels of normal newborn infants. J. Clin. Endocrinol. Metab. 47: 61, 1978.

    Article  PubMed  CAS  Google Scholar 

  44. Breall J.A., Rudolph A.M., Heymann M.A. Role of thyroid hormone in postnatal circulatory and metabolic adjustments. J. Clin. Invest. 73: 1418, 1984.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  45. Wu S.Y., Polk D.H., Klein A.H., Fisher D.A. The mechanism of low serum T3 in the fetus: hepatic T4-5′-monodeiodinase versus tissue sulfhydryl content — a clarification. J. Develop. Physiol. 8: 43, 1986.

    CAS  Google Scholar 

  46. Shepard T.H. Onset of function in the human fetal thyroid: biochemical and radioautographic studies from organ culture. J. Clin. Endocrinol. Metab. 27: 945, 1967.

    Article  PubMed  CAS  Google Scholar 

  47. Costa A., De Filippis B., Panizzo M., Girardi G., Bertino E., Arisio R., Mostert M., Trapani G., Fabris C. Development of thyroid function between VI–IX month of fetal life in humans. J. Endocrinol. Invest. 9: 273, 1986.

    Article  PubMed  CAS  Google Scholar 

  48. Greenberg A., Czernichow P., Reba R.C., Tyson J., Blizzard R.M. Observation on the maturation of thyroid function in early fetal life. J. Clin. Invest. 49: 1790, 1970.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  49. Oddie T.H., Fisher D.A., Bernard B., Lam R.W. Thyroid function at birth in infants of 30 to 45 weeks’ gestation. J. Pediatr. 90: 803, 1977.

    Article  PubMed  CAS  Google Scholar 

  50. Wilson D.M., Hopper A.O., McDougall I.R., Monika F.B., Hintz R.L., Stevenson D.K., Rosenfeld R.G. Serum free thyroxine values in term, premature and sick infants. J. Pediatr. 101: 113, 1982.

    Article  PubMed  CAS  Google Scholar 

  51. Ekins R. Roles of serum thyroxine-binding proteins and maternal thyroid hormones in fetal development. Lancet 1: 1129, 1985.

    Article  PubMed  CAS  Google Scholar 

  52. Obregon M.J., Mallol J., Pastor R., Morreale De Escobar G., Escobar Del Rey F. L-thyroxine and 3, 5, 3′-triiodo-L-thyronine in rat embryos before onset of fetal thyroid function. Endocrinology 114: 305, 1984.

    Article  PubMed  CAS  Google Scholar 

  53. Wrutniak C., Cabello G., Bosch M. Plasma free and total iodothyronine levels in hypophysectomized and intact lamb foetuses during the last third of gestation. Acta Endocrinol. (Kbh.) 110: 388, 1985.

    CAS  Google Scholar 

  54. Roti E., Fang S.L., Green K., Emerson C.H., Braverman L.E. Human placenta is an active site of thyroxine and 3, 3′, 5-triiodothyronine thyrosyl ring deiodination. J. Clin. Endocrinol. Metab. 53: 498, 1981.

    Article  PubMed  CAS  Google Scholar 

  55. Roti E., Fang S.L., Braverman L.E., Emerson C.H. Rat placenta is an active site of inner ring deiodination of thyroxine and 3, 3′, 5-triiodothyronine. Endocrinology 810: 34, 1982.

    Article  Google Scholar 

  56. Roti E., Braverman L.E., Fang S.L., Alex S., Emerson C.H. Ontogenesis of placental inner ring thyroxine deiodinase and amniotic fluid 3, 3′, 5′-triiodothyronine concentration in the rat. Endocrinology 111: 959, 1982.

    Article  PubMed  CAS  Google Scholar 

  57. Morreale De Escobar G., Pastor R., Obregon M.J., Escobar Del Rey F. Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function. Endocrinology 117: 1890, 1985.

    Article  Google Scholar 

  58. Cheron R.G., Kaplan M.M., Selenkow H.A., Crigler J.F. Jr. Neonatal thyroid function after propylthiouracil therapy fpr maternal Graves’ disease. N. Engl. J. Med. 304: 525, 1981.

    Article  PubMed  CAS  Google Scholar 

  59. Momotani N., Noh J., Oyanagy H., Ishikawa N., Ito K. Antithyroid drug therapy for Graves’ disease during pregnancy. Optimal regimen for fetal thyroid status. N. Engl. J. Med. 315: 24, 1986.

    Article  PubMed  CAS  Google Scholar 

  60. Robuschi G., Montermini M., Alboni A., Borciani E., Cersosimo G., Negrotti L., Gnudi A., Safran M., Braverman L.E., Roti E. Cord blood iodothyronine and thyrotropin concentrations in newborns of mothers exposed to povidone iodine in the last trimester of pregnancy. J. Endocrinol. Invest. 10: 183, 1987.

    Article  PubMed  CAS  Google Scholar 

  61. Lightner E.S., Fisher D.A., Giles H., Woolfenden J. Intra-amniotic injection of thyroxine (T4) to a human fetus. Evidence for conversion of T4 to reverse T3. Am. J. Obstet. Gynecol. 127: 487, 1977.

    PubMed  CAS  Google Scholar 

  62. Melmed S., Harada A., Murata Y., Socol M., Reed A., Carlson H.E:, Azukizawa M., Martini C., Jorgensen E., Hershman J.M. Fetal response to thyrotropin-releasing hormone after thyroid hormone administration to the Rhesus Monkey: lack of pituitary suppression. Endocrinology 105: 334, 1979.

    Article  PubMed  CAS  Google Scholar 

  63. Klein A.H., Fisher D.A. Thyrotropin-releasing hormone stimulated pituitary and thyroid gland responsiveness and 3, 5, 3’-triiodothyro-nine suppression in fetal and neonatal lambs. Endocrinology 106: 697, 1980.

    Article  PubMed  CAS  Google Scholar 

  64. Fukiishi Y., Itasegawa Y. Ontogeny of thyrotropin concentration in perinatal rats. Acta Endocrinol. (Kbh.) 110: 95, 1985.

    CAS  Google Scholar 

  65. Walker P., Coulombe P., Dussault J.H. Effects of triiodothyronine on thyrotropin-releasing hormone-induced thyrotropin release in the neonatal rat. Endocrinology 107: 1731, 1980.

    Article  PubMed  CAS  Google Scholar 

  66. Perry R.A., McIntosh G.H., Robinson P.M. Ultrastructural detection of the onset of pituitary thyrotroph sensitivity to lowered thyroid hormone concentrations in the fetal sheep. Acta Anat. 117: 42, 1983.

    Article  PubMed  CAS  Google Scholar 

  67. Tamagna E.I., Hershman J.M., Jorgensen E.C. Thyrotropin suppression by 3, 5-dimethyl-3’ isopropyl-L-thyronine in man. J. Clin. Endocrinol. Metab. 48: 196, 1979.

    Article  PubMed  CAS  Google Scholar 

  68. Comite F., Burrow G.N., Jorgensen E.C. Thyroid hormone analogs and fetal goiter. Endocrinology 102: 1670, 1978.

    Article  PubMed  CAS  Google Scholar 

  69. Bachrach L.K., Dibattista D., Burrow G.N., Holland F.J. Transplacental effects of 3, 5-dimethyl-3′-isopropyl-L-thyronine on fetal hypothyroidism in primates. Endocrinology 112: 2021, 1983.

    Article  PubMed  CAS  Google Scholar 

  70. Bachrach L.K., Kudlow J.E., Silverberg J.D.H., Kent G., Borrow G.N. Treatment of ovine cretinism in utero with 3,5-dymethyl-3′ isopropyl-L-thyronine. Endocrinology 111: 132, 1982.

    Article  PubMed  CAS  Google Scholar 

  71. Visser T.J., Leonard J.L., Kaplan M.M., Larsen P.R. Different pathways of iodothyronine 5′-deiodination in rat cerebral cortex. Biochem. Biophys. Res. Commun. 101: 1297, 1981.

    Article  PubMed  CAS  Google Scholar 

  72. Visser T.J., Leonard J.L., Kaplan M.M., Larsen P.R. Kinetic evidence suggesting two mechanisms for iodothyronine 5′-deiodination in rat cerebral cortex. Proc. Natl. Acad. Sci. USA 79: 5080, 1982.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  73. Cheron R.G., Kaplan M.M., Larsen P.R. Divergent changes of thyroxine 5-monodeiodination in rat pituitary and liver during maturation. Endocrinology 106: 1405, 1980.

    Article  PubMed  CAS  Google Scholar 

  74. El-Zaheri M.M., Braverman L.E., Vagenakis A.G. Enhanced conversion of thyroxine to triiodothyronine by the neonatal rat pituitary. Endocrinology 106: 1735, 1980.

    Article  PubMed  CAS  Google Scholar 

  75. McCann U.D., Shaw E.A., Kaplan M.M. Iodothyronine deiodination reaction types in several rat tissues: effects of age, thyroid status, and glucocorticoid treatment. Endocrinology 114: 1513, 1984.

    Article  PubMed  CAS  Google Scholar 

  76. Segall-Blank M., Connolly J.L., Ingbar S.H. Comparative studies of the metabolism of thyroxine in the pituitaries of pregnant sheep and their fetuses. Endocrinology 111: 996, 1982.

    Article  Google Scholar 

  77. Naito K., Inada M., Mashio Y., Tanaka K., Ishii H., Nishikawa M., Imura H. Reciprocal relation between serum thyrotropin levels and intrapituitary 3, 5, 3′-L-triiodothyronine generating activity from thyroxine in perinatal rats. Endocrinol. Jpn. 28: 461, 1981.

    Article  PubMed  CAS  Google Scholar 

  78. Bernal J., Pekonen F. Ontogenesis of the nuclear 3, 5, 3′-triiotlothyronine receptor in the human fetal brain. Endocrinology 114: 677, 1984.

    Article  PubMed  CAS  Google Scholar 

  79. Perez Castillo A., Bernal J., Ferreiro B., Pans T. The early ontogenesis of thyroid hormone receptor in the rat fetus. Endocrinology 117: 2457, 1985.

    Article  Google Scholar 

  80. Schwartz H.L., Oppenheimer J.H. Ontogenesis of 3, 5, 3′-triiodothyronine receptors in neonatal rat brain: dissociation between receptor concentrations and stimulation of oxygen consumption by 3, 5, 3′-triiodothyronine. Endocrinology 103: 943, 1978.

    Article  PubMed  CAS  Google Scholar 

  81. Coulombe P., Ruel J., Faure R., Dussault J.H. Pituitary nuclear triiodothyronine receptors during development in the rat. Am. J. Physiol. 245: E81, 1983.

    PubMed  CAS  Google Scholar 

  82. Azizi F., Vagenakis A.G., Bollinger J., Reichlin S., Braverman L.E., Ingbar S.H. Persistent abnormalities in pituitary function following neonatal thyrotoxicosis in the rat. Endocrinology 94: 1681, 1974.

    Article  PubMed  CAS  Google Scholar 

  83. Dussault J.A., Coulombe P., Walker P. Effects of neonatal hyperthyroidism on the development of the hypothalamic pituitary-thyroid axis in the rat. Endocrinology 110: 1037, 1982.

    Article  PubMed  CAS  Google Scholar 

  84. Besa M.E., Pascual-Leone A.M. Effect of neonatal hyperthyroidism upon the regulation of TSH secretion in rats. Acta Endocrinol. (Kbh.) 105: 31, 1984.

    CAS  Google Scholar 

  85. Walker P., Courtin F. Transient neonatal hyperthyroidism results in hyperthyroidism in the adult rat. Endocrinology 116: 2246, 1985.

    Article  PubMed  CAS  Google Scholar 

  86. Porterfield S.P. Prenatal exposure of the fetal rat to excessive L-thyroxine or 3, 5-Dimethyl-3′isopropyl-thyronine produces persistent changes in the thyroid control system. Horm. Metab. Res. 17: 655, 1985.

    Article  PubMed  CAS  Google Scholar 

  87. Bakke J.L., Lawrence N.L., Bennett J., Robinson S. Endocrine syndromes produced by neonatal hyperthyroidism, hypothyroidism, or altered nutrition and effects seen in untreated progeny. In: Fisher D.A., Burrow G.N. (Eds.), Perinatal thyroid physiology and disease. Raven Press, New York, 1975, p. 79.

    Google Scholar 

  88. Homoki J., Birk J., Lods U., Rothenbuchner G., Fazekas A.T.A., Teller W.M. Thyroid function in newborns with congenital goiter. J. Pediatr. 86: 753, 1975.

    Article  PubMed  CAS  Google Scholar 

  89. Sato T., Suzuki Y., Taketani T., Ishiguro K., Nakajuma H. Age related change in pituitary threshold for TSH release during thyroxine replacement therapy for cretinism. J. Clin. Endocrinol. Metab. 44: 553, 1977.

    Article  PubMed  CAS  Google Scholar 

  90. Schultz R., Glassman M., Macgillivaray H. Elevated threshold for thyrotroph suppression in congenital hypothyroidism. Am. J. Dis. Child. 134: 19, 1980.

    PubMed  CAS  Google Scholar 

  91. Redmond G.P., Soyka L.F. Abnormal TSH secretory dynamic in congenital hypothyroidism. J. Pediatr. 98: 83, 1981.

    Article  PubMed  CAS  Google Scholar 

  92. Focarile F., Rondanini G.F., Bollati A., Bartolucci A., Chiumello G. Free thyroid hormones in evaluating persistently elevated thyrotropin levels in children with congenital hypothyroidism on replacement therapy. J. Clin. Endocrinol. Metab. 59: 1211, 1984.

    Article  PubMed  CAS  Google Scholar 

  93. Silva E.J., Matthews P.S. Production rates and turnover of triiodothyronine in rat developing cerebral cortex and cerebellum responses to hypothyroidism. J. Clin. Invest. 74: 1035, 1984.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  94. Cavaliere H., Medeiros Neto G.A., Rosner W., Kourides I.A. Persistent pituitary resistance to thyroid hormone in congenital versus later-onset hypothyroidism. J. Endocrinol. Invest. 8: 527, 1985.

    Article  PubMed  CAS  Google Scholar 

  95. Jackson I.M.D. Thyrotropin-releasing hormone. N. Engl. J. Med. 306: 145, 1982.

    Article  PubMed  CAS  Google Scholar 

  96. Winters A.J., Eskay R.L., Porter J.C. Concentration and distribution of TRH and LRH in the human fetal brain. J. Clin. Endocrinol. Metab. 39: 960, 1974.

    Article  PubMed  CAS  Google Scholar 

  97. Aubert M.L., Grumbach M.M., Kaplan S.L. The ontogenesis of human fetal hormones. IV. Somatostatin, luteinizing hormone releasing factor, and thyrotropin releasing factor in hypothalamus and cerebral cortex of human fetuses 10–22 weeks of age. J. Clin. Endocrinol. Metab. 44: 1130, 1977.

    Article  PubMed  CAS  Google Scholar 

  98. Lamberton R.P., Lechan R.M., Jackson I.M.D. Ontogeny of thyrotropin-releasing hormone and histidyl-prolinediketopiperazine in the rat central nervous system and pancreas. Endocrinology 115: 2400, 1984.

    Article  PubMed  CAS  Google Scholar 

  99. Gayo L., Bonet B., Herranz A.S., Iglesias R., Toro M.J., Montoya E. Postnatal development of brain TRH, serum TSH and thyroid hormones in the male and female rat. Acta Endocrinol. (Kbh.) 112: 7, 1986.

    CAS  Google Scholar 

  100. Lombardi G., Lupoli G., Scopacasa F., Panza R., Minozzi M. Plasma immunoreactive thyrotropin-releasing hormone (TRH) values in normal newborns. J. Endocrinol. Invest. 1: 69, 1978.

    Article  PubMed  CAS  Google Scholar 

  101. Gibbons J.M., Mitnick M., Chieffo V. In vitro biosynthesis of TSH-and LH-releasing factors by the human placenta. Am. J. Obstet. Gynecol. 121: 127, 1975.

    PubMed  CAS  Google Scholar 

  102. Shambaugh G. III, Kubek M., Wilber J.F. Thyrotropin-releasing hormone activity in the human placenta. J. Clin. Endocrinol. Metab. 48: 483, 1979.

    Article  PubMed  CAS  Google Scholar 

  103. Youngblood W.W., Humm J., Dizer J.S. TRH-like immunoreactivity in rat pancreas and eye bovine and sheep pineals, and human placenta: non-identity with synthetic pyroglu-his-pro-NH2 (TRH). Brain Res. 163: 101, 1979.

    Article  PubMed  CAS  Google Scholar 

  104. Morley J.E., Bashore R.A., Reed A., Carlson H.E., Hershman J.M. Thyrotropin-releasing hormone and thyroid hormones in amniotic fluid. Am. J. Obstet. Gynecol. 134: 581, 1979.

    PubMed  CAS  Google Scholar 

  105. Engler D., Scanion M.F., Jackson I. Thyrotropin-releasing hormone in the systemic circulation of the neonatal rat is derived from the pancreas and other extraneural tissues. J. Clin. Invest. 67: 800, 1981.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  106. Banerji A., Prasad C. The postnatal development of the pituitary thyrotropinreleasing hormone receptor in male and female rats. Endocrinology 110: 663, 1982.

    Article  PubMed  CAS  Google Scholar 

  107. Dussault J.H., Coulombe P. Pituitary receptors during development in the rat. I. TRH binding capacity. Pediatr. Res. 17: 270, 1983.

    Article  PubMed  CAS  Google Scholar 

  108. Pezzino V., Distefano G., Belfiore A., Filetti S., Mazzone D., Grasso S. Role of thyrotropin-releasing hormone in the development of pituitary-thyroid axis in four anencephalic infants. Acta Endocrinol. (Kbh.) 101: 538, 1982.

    CAS  Google Scholar 

  109. Grasso S., Filetti S., Mazzone D., Pezzino V., Vigo R., Vigneri R. Thyroid-pituitary function in eight anencephalic infants. Acta Endocrinol. (Kbh.) 93: 396, 1980.

    CAS  Google Scholar 

  110. Theodoropoulos T., Braverman L.E., Vagenakis A.G. Thyrotropin-releasing hormone is not required for thyrotropin secretion in the perinatal rat. J. Clin. Invest. 63: 588, 1979.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  111. Oliver C., Giraud P., Lissitzky J.C., Conte-Delvox B., Gillioz P. Influence of thyrotropin-releasing hormone on the secretion of thyrotropin in neonatal rats. Endocrinology 108: 179, 1981.

    Article  PubMed  CAS  Google Scholar 

  112. Strbak V., Greer M.A. Acute effects of hypothalamic ablation on plasma thyrotropin and prolactin concentrations in the suckling rat: evidence that early postnatal pituitary-thyroid regulation is independent of hypothalamic control. Endocrinology 105: 488, 1979.

    Article  PubMed  CAS  Google Scholar 

  113. Tonooka N., Greer M.A. Evidence that control of fetal thyrotropic secretion is independent of both the fetal and maternal hypothalamus. Endocrinology 102: 852, 1978.

    Article  PubMed  CAS  Google Scholar 

  114. Allen J.P., Greer M.A., McGilvra R., Castro A., Fisher D.A. Endocrine function in an anencephalic infant. J. Clin. Endocrinol. Metab. 38: 94, 1974.

    Article  PubMed  CAS  Google Scholar 

  115. De Luca F., Trimarchi F., Carducci Artenisio A., Abate F., Baviera G., Cucinotta D., Gemelli M. Studio funzionale dell’adenoipofisi in due neonati anencefalici. J. Endocrinol. Invest. 4 (Suppl. 1): 19, 1981.

    Google Scholar 

  116. Azukizawa M., Murata Y., Ikenoue T., Martin C.B., Hershman J.M. Effect of thyrotropin-releasing hormone on secretion of thyrotropin, prolactin, thyroxine, and triiodothyronine in pregnant and fetal Rhesus Monkey. J. Clin. Endocrinol. Metab. 43: 1020, 1976.

    Article  PubMed  CAS  Google Scholar 

  117. Roti E., Gnudi A., Braverman L.E., Robuschi G., Emanuele R., Bandini P., Benassi L., Pagliani A., Emerson C.H. Human cord blood concentration of thyrotropin, thyroglobulin, and iodothyronines after maternal administration of thyrotropin-releasing hormone. J. Clin. Endocrinol. Metab. 53: 813, 1981.

    Article  PubMed  CAS  Google Scholar 

  118. Jacobsen B.B., Andersen H., Dige-Petersen H., Hummer L. Thyrotropin response to thyrotropin-releasing hormone in full term, euthyroid and hypothyroid newborns. Acta Pediatr. Scand. 65: 433, 1976.

    Article  CAS  Google Scholar 

  119. Jacobsen B.B., Andersen H., Dige-Petersen H., Hummer L. Pituitary-thyroid responsiveness to thyrotropin-releasing hormone in preterm and small-for gestational age newborns. Acta Pediatr. Scand. 66: 541, 1977.

    Article  CAS  Google Scholar 

  120. Neary J.T., Nakamura C., Davies I.J., Soodak M., Maloof F. Lower levels of thyrotropin-releasing hormone degrading activity in human cord and in maternal sera than in the serum of euthyroid, non pregnant adults. J. Clin. Invest. 62: 1, 1978.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  121. Aratan-Spire S., Czernichow P. Thyrotropin-releasing hormone degrading activity of neonatal human plasma. J. Clin. Endocrinol. Metab. 50: 88, 1980.

    Article  PubMed  CAS  Google Scholar 

  122. Snyder P.J., Utiger R.D. Response to thyrotropin-releasing hormone (TRH) in normal man. J. Clin. Endocrinol. Metab. 34: 380, 1972.

    Article  PubMed  CAS  Google Scholar 

  123. Roti E., Gnudi A., Robuschi G., Emanuele R., Benassi L., Braverman L.E. Response of growth hormone to thyrotropin-releasing hormone (TRH) during fetal life. J. Clin. Endocrinol. Metab. 54: 1255, 1982.

    Article  PubMed  CAS  Google Scholar 

  124. Reichlin S. Somatostatin. N. Engl. J. Med. 309: 1495, 1983.

    Article  PubMed  CAS  Google Scholar 

  125. Bugnon C., Fellman D., Bloch B. Immunocytochemical study of the ontogenesis of the hypothalamic somatostatin-containing neurons in the human fetus. Cell Tissue Res. 183: 319, 1977.

    Article  PubMed  CAS  Google Scholar 

  126. Saito H., Saito S., Sano T., Hosoi E., Saito H. Fetal and maternal plasma levels of immunoreactive somatostatin at delivery: evidence for its increase in the umbilical artery and its arterio-venous gradient in the feto-placental circulation. J. Clin. Endocrinol. Metab. 56: 567, 1983.

    Article  PubMed  CAS  Google Scholar 

  127. Koshimizu T., Ohyama Y., Yokota Y., Ohtsuka K. Peripheral plasma concentrations of somatostatin-like immunoreactivity in newborns and infants. J. Clin. Endocrinol. Metab. 61: 78, 1985.

    Article  PubMed  CAS  Google Scholar 

  128. Nishihira M., Yagihashi S. Immunohistochemical demonstration of somatostatincontaining cells in human placenta. Tohoku J. Exp. Med. 126: 391, 1978.

    Article  Google Scholar 

  129. Watkins W.B., Yen S.S.C. Somatostatin in cytotrophoblast of the immature human placenta: localization by immunoperoxidase cytochemistry. J. Clin. Endocrinol. Metab. 50: 969, 1980.

    Article  PubMed  CAS  Google Scholar 

  130. Fitz-Patrick D., Patel Y.C. Evidence for somatostatin precursors in human stomach, placenta and amniotic fluid. J. Clin. Endocrinol. Metab. 53: 372, 1981.

    Article  PubMed  CAS  Google Scholar 

  131. Nan Lee J., Wu P., Chard T. Identification of somatostatin in the human placenta. Acta Endocrinol. (Kbh.) 99: 601, 1982.

    Google Scholar 

  132. Fitz-Patrick D., Patel Y.C. Measurement, characterization, and source of somatostatin-like immunoreactivity in human amniotic fluid. J. Clin. Invest. 64: 737, 1979.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  133. Dubois P.M., Paulin C., Assan R., Dubois M.P. Evidence for immunoreactive somatostatin in the endocrine cells of human foetal pancreas. Nature 256: 731, 1975.

    Article  PubMed  CAS  Google Scholar 

  134. Chayvialle J.A., Paulin C., Dubois P.M., Descos F., Dubois M.P. Ontogeny of somatostatin in the human gastro-intestinal tract, endocrine pancreas and hypothalamus. Acta Endocrinol. (Kbh.) 94: 1, 1980.

    CAS  Google Scholar 

  135. Goodyer C.G., St George Hall C., Guyda H., Robert F., Giroud J.P. Human fetal pituitary in culture: hormone secretion and response to somatostatin luteinizing hormone releasing factor, thyrotropin releasing factor and dibutyryl cyclic AMP. J. Clin. Endocrinol. Metab. 45: 73, 1977.

    Article  PubMed  CAS  Google Scholar 

  136. Oliver C., Giraud P., Lissitzky J.C., Cote J., Boudouresque F., Gillioz P., Conte-Delvox B. Influence of endogenous somatostatin on growth hormone and thyrotropin secretion in neonatal rats. Endocrinology 110: 1018, 1982.

    Google Scholar 

  137. Arimura A., Schally A.V. Increase in basal and thyrotropin-releasing hormone (TRH)-stimulated secretion of thyrotropin (TSH) by passive immunization with antiserum to somatostatin in rats. Endocrinology 98: 1069, 1976.

    Article  PubMed  CAS  Google Scholar 

  138. Theodoropoulos T.J. Somatostatin is a regulator of thyrotropin secretion in the perinatal rat. Endocrinology 117: 1683, 1985.

    Article  PubMed  CAS  Google Scholar 

  139. Sack J., Fisher D.A., Grajwer L.A., Lam R.W., Wang C.C. The response of newborn sheep to TRH with and without somatostatin. Endocrinology 100: 1533, 1977.

    Article  PubMed  CAS  Google Scholar 

  140. Roti E., Robuschi G., Alboni A., Emanuele R., d’Amato L., Gardini E., Salvi M., Dall’Aglio E., Gnudi A., Braverman L.E. Inhibition of foetal growth hormone (GH) and thyrotropin (TSH) secretion after maternal administration of somatostatin. Acta Endocrinol. (Kbh.) 106: 393, 1984.

    CAS  Google Scholar 

  141. Bertler A. Occurrence and localization of catecholamines in the human brain. Acta Physiol. Scand. 51: 97, 1961.

    Article  CAS  Google Scholar 

  142. Gluckman P.D., Leisti S., Kaplan S.L., Grumbach M.M. Hormone ontogeny in the ovine fetus. XV. Studies of adenohypophyseal hormones after fetal pituitary stalk section: evidence for an extrahypothalamic dopaminergic influence on fetal prolactin secretion. Endocrinology 112: 1624, 1983.

    Article  PubMed  CAS  Google Scholar 

  143. Gluckman P.D., Marti-Henneberg C., Thomsett M.J., Kaplan S.L., Rudolph A.M., Grumbach M.M. Hormone ontogeny in the ovine fetus. VI. Dopaminergic regulation of prolactin secretion. Endocrinology 105: 1173, 1979.

    Article  PubMed  CAS  Google Scholar 

  144. Roti E., Robuschi G., Emanuele R., d’Amato L., Gnudi A., Fatone M., Benassi L., Foscolo M.S., Gualerzi C., Braverman L.E. Failure of metoclopramide to affect thyrotropin concentration in the term human fetus. J. Clin. Endocrinol. Metab. 56: 1071, 1983.

    Article  PubMed  CAS  Google Scholar 

  145. Roti E., Robuschi G., Alboni A., d’Amato L., Montermini M., Gardini E., Salvi M., Borciani E., Dall’Aglio E., Bisi S., Zammarchi G., Lasagni R., Gnudi A., Braverman L.E. Human foetal prolactin but not thyrotropin secretion is decreased by bromocriptine. Acta Endocrinol. (Kbh.) 112: 35, 1986.

    CAS  Google Scholar 

  146. Bigazzi M., Ronga R., Lancranjan I., Ferraro S., Branconi F., Buzzoni P., Martorana G., Scarselli G.F., Del Pozo E. A pregnancy in an acromegalic woman during bromocriptine treatment: effects on growth hormone and prolactin in the maternal, fetal, and amniotic compartments. J. Clin. Endocrinol. Metab 48: 9, 1979.

    Article  PubMed  CAS  Google Scholar 

  147. Miyakawa I., Taniyama K., Koike H., Mori N., Nagamine M., Kuribayashi T., Araki S. Successful pregnancy in an acromegalic patient during 2-Br-alpha-ergocryptine (CB-154) therapy. Acta Endocrinol. (Kbh.) 101: 333, 1982.

    CAS  Google Scholar 

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This work was supported in part by Grants 84.01778.04 and 85.00533.04 of Consiglio Nazionale delle Ricerche, Rome, Italy.

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Roti, E. Regulation of thyroid-stimulating hormone (TSH) secretion in the fetus and neonate1. J Endocrinol Invest 11, 145–158 (1988). https://doi.org/10.1007/BF03350124

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