Journal of Endocrinological Investigation

, Volume 11, Issue 1, pp 43–45 | Cite as

Primary hypothyroidism due to leukemic infiltration of the thyroid gland

  • V. Foresti
  • E. Parisio
  • N. Scolari
  • A. Ungaro
  • A. Villa
  • F. Confalonieri
Case Report


We describe a patient with acute B-lymphocyte lymphoblastic leukemia who developed laboratory changes (not detectable free thyroxine, TSH 66 μlU/ml) suggesting severe primary hypothyroidism. Histological examination at autopsy showed massive leukemic infiltration of the thyroid gland: the progressive reduction of thyroid hormone levels with concomitant increase in TSH levels observed over a three-month period from the onset of the hemopathy suggests a cause-effect relationship between leukemic infiltration of the thyroid gland and hypothyroidism.


Primary hypothyroidism acute lymphoblastic leukemia 


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  1. 1.
    Shimaoka K., Sokal J.E., Pickren J.W. Metastatic neoplasms in the thyroid gland. Cancer 15: 557, 1962.PubMedCrossRefGoogle Scholar
  2. 2.
    Mortensen J.D., Woolner LB., Bennett W.A. Secondary malignant tumors of the thyroid gland. Cancer 9: 306, 1956.PubMedCrossRefGoogle Scholar
  3. 3.
    Compagno J., Oertel J.E. Malignant lymphoma and other lymphoproliferative disorders of the thyroid gland: a clinicopathologic study of 245 cases. Am. J. Clin. Pathol. 74: 1, 1980.PubMedGoogle Scholar
  4. 4.
    Hamburger J.I., Miller J.M., Kini S.R. Lymphoma of the thyroid. Ann. Intern. Med. 99: 685, 1983.PubMedCrossRefGoogle Scholar
  5. 5.
    Larsen P.R., Vickery A.L. Case report of the Massachusetts General Hospital (case 15, 1987). N. Engl. J. Med. 316: 931, 1987.CrossRefGoogle Scholar
  6. 6.
    Shimaoka K., VanHerle A.J., Dindogru A. Thyrotoxicosis secondary to involvement of the thyroid with malignant lymphoma. J. Clin. Endocrinol. Metab. 43: 64, 1976.PubMedCrossRefGoogle Scholar
  7. 7.
    Hendersen E.S. Acute leukemia — General consideration. In: Williams W.J., Beutler E., Erslev A.J., Lichtman M.A., (Eds.), Hematology, ed. 3. McGraw — Hill Book Company, New York, 1983, p. 231.Google Scholar
  8. 8.
    Klein T., Laedlein-Greilsammer D., Methlin G., Grob J.C., Kuntzmann J. A propos de 9 cas de localisations intrathyroïdiennes de leucémies et d’hématosarcomes. Bull. Cancer (Paris) 59: 169, 1972.Google Scholar
  9. 9.
    Uderzo C., Di Natale B., Locasciulli A., Adamoli L., Nizzoli G., Mariani R., Rondanini G., Masera G. Endocrine study after interruption of therapy in children with acute lymphoblastic leukemia. Haematologica 67: 642, 1982.PubMedGoogle Scholar
  10. 10.
    Ingbar S.H. The thyroid gland. In: Wilson J.D., Foster D.W. (Eds.), Textbook of Endocrinology, ed. 7. W.B. Saunders Company, Philadelphia, 1985, p. 780.Google Scholar
  11. 11.
    Burger A., Nicod P., Suter P., Vallotton M.B. Reduced active thyroid hormone levels in acute illness. Lancet 1: 653, 1976.PubMedCrossRefGoogle Scholar
  12. 12.
    Wartofsky L., Burman K.D. Alterations in the thyroid function in patients with systemic illness: the “euthyroid sick syndrome”. Endocr. Rev. 3: 164, 1982.PubMedCrossRefGoogle Scholar
  13. 13.
    Chopra I.J., Hershman J.M., Pardrige W.M., Nicoloff J.T. Thyroid function in nonthyroidal illness. Ann. Intern. Med. 98: 946, 1983.PubMedCrossRefGoogle Scholar
  14. 14.
    Melmed S., Geola F.L., Reed A.W. A comparison of methods for assessing thyroid function in non thyroidal illness. J. Clin. Endocrinol. Metab. 54: 300, 1982.PubMedCrossRefGoogle Scholar
  15. 15.
    Kaptein E.M. Thyroxine kinetics in nonthyroidal illnesses. J. Endocrinol. Invest. 9: (Suppl. 4) 37, 1986.PubMedGoogle Scholar
  16. 16.
    Carter J.N., Eastman C.J., Corcoran J.M., Lazarus L. Effect of severe, chronic illness on thyroid function. Lancet 2: 971, 1974.PubMedCrossRefGoogle Scholar
  17. 17.
    Brent G. A., Hershman J.M., Braunstein G.D. Patients with severe nonthyroidal illness and serum thyrotropin concentrations in the hypothyroid range. * Am. J. Med. 81: 463, 1986.PubMedCrossRefGoogle Scholar
  18. 18.
    Gordin A., Hainonen O.P., Saarinen P., Lamberg B.A. Serum thyrotropin in symptomless autoimmune thyroiditis. Lancet 1: 551, 1972.PubMedCrossRefGoogle Scholar
  19. 19.
    Baker B.A., Gharib H., Markowitz H. Correlation of thyroid antibodies and cytologic features in suspected autoimmune thyroid disease. Am. J. Med. 74: 941,1983.PubMedCrossRefGoogle Scholar
  20. 20.
    Aho K., Gordin A., Palosuo T., Takala J. Development of thyroid autoimmunity. Acta Endocrinol. (Kbh.) 108: 61, 1985.Google Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 1988

Authors and Affiliations

  • V. Foresti
    • 1
  • E. Parisio
    • 1
  • N. Scolari
    • 1
  • A. Ungaro
    • 1
  • A. Villa
    • 1
  • F. Confalonieri
    • 1
  1. 1.Ospedale Fatebenefratelli — Oftalmico, III Divisione di MedicinaMilanoItaly

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