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Localized myxedema on the nasal dorsum in a patient with Graves’ disease: Report of a case

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Abstract

We report the case of a 56-year-old Japanese female with Graves’ disease associated with localized myxedema on the nasal dorsum. The patient developed localized myxedema concomitantly with hyperthyroidism before antithyroid therapy was given. The lesion was totally removed surgically, as it was small and well circumscribed. Although unusual locations of localized myxedema have been reported elsewhere, there is to date no case of localized myxedema on the nasal dorsum without involvement of the pretibial area reported in the literature. We discuss this unique feature of our patient.

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References

  1. Gimlette T. Pretibial myxoedema. Br. Med. J. 2: 348, 1960.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Haydar N.A. Exophthalmos, digital clubbing and pretibial myxedema in thyroiditis. J. Clin. Endocrinol. Metab. 23: 215, 1963.

    Article  CAS  PubMed  Google Scholar 

  3. Horiuch Y. Pretibial myxedema associated with chronic thyroiditis. Arch. Dermatol. 121: 451, 1985.

    Article  Google Scholar 

  4. Stewart G., Rowland Payne C.M.E., Croft D.N. Hashimoto’s thyroiditis associated with dysthyroid eye disease, pretibial myxedema and thyroid acropathy. J. Roy. Soc. Med. 77: 240, 1980.

    Google Scholar 

  5. Lynch P.J., Maize J.C., Sisson J.C. Pretibial myxedema and non-thyrotoxic thyroid disease. Arch. Dermatol. 107: 107, 1973.

    Article  CAS  PubMed  Google Scholar 

  6. Kasagi K., Konishi J., Arai K., Misaki T., Iida Y., Endo K., Torizuka, K. A sensitive and practical assay for thyroid-stimulating antibodies using crude immunoglobulin fractions precipitated with polyethylene glycol. J. Clin. Endocrinol. Metab. 62: 855, 1986.

    Article  CAS  PubMed  Google Scholar 

  7. Kasagi K., Konishi J., Iida Y., Tokuda Y., Arai K., Endo K., Torizuka K. A sensitive and practical assay for thyroid-stimulating antibodies using FRTL-5 thyroid cells. Acta Endocrinol. (Copenh.) 115: 30, 1987.

    CAS  Google Scholar 

  8. Southgate K., Creeagh F., Teece M., Kingswood C., Smith B.R. A receptor assay for the measurement of TSH receptor antibodies in unextracted serum. Clin. Endocrinol. (Oxf.) 20: 539, 1984.

    Article  CAS  Google Scholar 

  9. Cairns R.J. Pretibial myxedema. In: Rook A., Wilkinson D.S., Ebling F.J.G. (Eds.), Textbook of Dermatology. Blackwell Scientific Publisher, Oxford-Edinburgh, 1972, p. 107.

    Google Scholar 

  10. Sisson J.C. Hyalunic acid in localized myxedema. J. Clin. Endocrinol. Metab. 28: 433, 1968.

    Article  CAS  PubMed  Google Scholar 

  11. Cohen B.D., Benua R.S., Rawson R.W. Localized myxedema involving the upper extremities. Arch. Intern. Med. 111: 153, 1963.

    Article  Google Scholar 

  12. Sunseri J. Elephantiasic papulonodular myxedema. Arch. Dermatol. Syph. 48: 70, 1943.

    Article  Google Scholar 

  13. Braverman I.M. Endocrine and Metabolic Diseases. In: Braverman I.M. (Eds.), Skin Signs of Systemic Diseases. WB Saunders Co., Philadelphia, 1981, p. 613.

    Google Scholar 

  14. Slater D.N. Cervical nodular localized myxoedema in a thyroidectomy scar: light and electron microscopy and histochemical findings. Clin. Exp. Dermatol. 12: 216, 1987.

    Article  CAS  PubMed  Google Scholar 

  15. Noppakun N., Bancleun K., Chaudraprasert S. Unusual localization of localized myxedema in Graves’ disease. Arch. Dermatol. 122: 85, 1986.

    Article  CAS  PubMed  Google Scholar 

  16. Nixon D.W., Samols E. Acral changes associated with thyroid disease. JAMA 212: 1175, 1970.

    Article  CAS  PubMed  Google Scholar 

  17. Schermer D.R., Roenigk H.H. Jr., Schumacher O.P., McKenzie J.M. Relationship of long-acting thyroid stimulator to pretibial myxedema. Arch. Dermatol. 102: 62, 1970.

    Article  CAS  PubMed  Google Scholar 

  18. Cheung H.S., Nicoloff J.T., Kamiel M.B., Spolter L., Nimni M.E. Stimulation of fibroblast biosynthetic activity by serum of patients with pretibial myxedema. J. Invest. Dermatol. 71: 12, 1978.

    Article  CAS  PubMed  Google Scholar 

  19. Jolliffe D.S., Gaylarde P.M., Brock A.P., Sarkang I. Pretibial myxoedema: stimulation of mucopolysaccharide production of fibroblasts by serum. Br. J. Dermatol. 101: 557, 1979.

    Article  CAS  PubMed  Google Scholar 

  20. Konrad K., Brenner W., Pehamberger H. Ultrastructure and immunological findings in Graves’ disease with pretibial myxedema. J. Cutan. Pathol. 7: 99, 1980.

    Article  CAS  PubMed  Google Scholar 

  21. Dandona P., Marshall N.J., Bidey S.P. Successful treatment of exophthalmos and pretibial myxedema with plasmapheresis. Br. Med. J. 1: 373, 1979.

    Google Scholar 

  22. Lewis R.A., Slaton N., Croft D.N. Exophthalmos and pretibial myxoedema not responding to plasmapheresis. Br. Med. J. 2: 390, 1979.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Kriss J.P., Pleshakov V., Rosenblum A. Therapy with occlusive dressing of pretibial myxedema with fluocinolone acetonide. J. Clin. Endocrinol. Metab. 27: 595, 1967.

    Article  CAS  PubMed  Google Scholar 

  24. Inch R.S. Localized pretibial myxoedema treated with cortisone. Lancet. 2: 1239, 1953.

    Article  Google Scholar 

  25. Kucer K.A., Lucombe H.A., Kauh Y.C. Pretibial myxedema: recurrence after skin grafting. Arch. Dermatol. 116: 1076, 1980.

    Article  CAS  PubMed  Google Scholar 

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Akasu, F., Takazawa, K., Akasu, R. et al. Localized myxedema on the nasal dorsum in a patient with Graves’ disease: Report of a case. J Endocrinol Invest 12, 717–721 (1989). https://doi.org/10.1007/BF03350040

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