Journal of Endocrinological Investigation

, Volume 18, Issue 10, pp 749–753 | Cite as

Simple radioimmunological assay of anti-α-galactosyl antibody (anti-Gal): Application to autoimmune thyroid diseases and thyroid-associated ophthalmopathy

  • R. J. Winand
  • J. Winand-Devigne
  • C. Cox
  • C. Caulier
  • M. Meurisse


Two radioimmunological techniques for the measurement of anti-α-galactosyl (anti-Gal) antibodies were developed and we demonstrated that this antibody is present in the serum of most untreated patients with Graves’ disease, thyroid-associated ophthalmopathy (TAO) and autoimmune thyroiditis. Thyrotropin-binding inhibiting immunoglobulins (TBII) and Thyroid Stimulating Antibodies (TSAb) are frequently found in serum of patients with Graves’ disease but not with autoimmune thyroiditis. Although TBII and anti-Gal were found sometimes simultaneously in the same serum samples, we demonstrated that anti-Gal could be present in the absence of TBII and reciprocally.


Anti α-galactosyl antibody measurement autoimmune thyroid disease thyroid-associated ophtalmopathy 


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Copyright information

© Italian Society of Endocrinology (SIE) 1995

Authors and Affiliations

  • R. J. Winand
    • 1
  • J. Winand-Devigne
    • 1
  • C. Cox
    • 2
  • C. Caulier
    • 2
  • M. Meurisse
    • 3
  1. 1.The Thyroid UnitInstitute of Pathology, CHUSart-TilmanBelgium
  2. 2.RADIM S.A., Parc Scientifique du Sart-TilmanLiègeBelgium
  3. 3.Department of Abdominal and General Surgery, CHUSart-TilmanBelgium

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