Advertisement

Journal of Endocrinological Investigation

, Volume 13, Issue 2, pp 85–89 | Cite as

A study of pineal-prolactin interaction: prolactin response to an acute melatonin injection in patients with hyperprolactinemia

  • P. Lissoni
  • E. Mainini
  • C. Mazzi
  • G. Cattaneo
  • S. Barni
Article

Abstract

Several studies demonstrated that the pineal gland plays a regulatory role on PRL secretion. At present, however, there are few clinical data only about the pineal function in PRL secretion disorders. To further clarify which is the pineal importance in the dysfunctions of PRL release, we have evaluated the effect of an acute injection of the pineal hormone melatonin in 19 patients with hyperprolactinemia, 8 of whom had idiopathic hyperprolactinemia, while the other 11 had a prolactinoma. Melatonin was given im at a dose of 20 mg at 09:00 h, and venous blood samples were collected at — 20, 0, 20, 60, 120, 180 min. A normalization of PRL levels was achieved after melatonin injection in 3/8 patients with idiopathic hyperprolactinemia, while no effect was seen in patients with prolactinoma. Further studies, by evaluating the effect of a chronic treatment, will be required to define which is the action of melatonin on PRL release in PRL secretion disorders, and to evaluate its possible therapeutic role.

Key-words

Hyperprolactinemias melatonin pineal gland prolactin prolactinomas 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Blask D.E. The pineal, an oncostatic gland? In: Reith R.I. (Ed.), The Pineal Gland. Raven Press, New York, 1984, p. 276.Google Scholar
  2. 2.
    Quay W.B. Spontaneous adenomata of the hypophyseal anterior lobe in aged pinealectomized rats. Experientia 23: 129, 1967.PubMedCrossRefGoogle Scholar
  3. 3.
    Wetterberg L. Melatonin in humans: physiological and clinical studies. J. Neural Transm. (Suppl.) 13: 289, 1978.Google Scholar
  4. 4.
    Mauri R., Lissoni P., Liuzzi A., Dallabonzana D., Tagliaferri A., Resentini M., Morabito F, Fraschini F. The pineal gland function in pituitary tumours: serum levels of melatonin in acromegaly and prolactinomas. J. Endocrinol. Invest. 8 (Suppl. 1): 14, 1985.Google Scholar
  5. 5.
    Kamberi I.A., Mical R.S., Porter J.C. Effects of melatonin and serotonin on the release of FSH and prolactin. Endocrinology 88: 1288, 1971.PubMedCrossRefGoogle Scholar
  6. 6.
    Cardinali D.P., Faignon M.R., Scacchi P., Moguilevsky J. Failure of melatonin to increase serum prolactin levels in ovariectomised rats subjected to superior cervical ganglionectomy or pinealectomy. J. Endocrinol. 82: 315, 1979.PubMedCrossRefGoogle Scholar
  7. 7.
    Vaughan M.K., Johnson L.Y., Blask D.E., Reiter R.J. Melatonin stimulation of prolactin secretion in male rats: influence of pinealectomy, castration or gonadal steroid pretreatment. In: Birau N., Schloot W. (Eds.). Advanced in the Biosciences. Pergamon Press, Oxford, 1981, p. 165.Google Scholar
  8. 8.
    Blask D.L, Nodelman J.L. Antigonadotrophic and prolactin-inhibitory effects of melatonin in anosmic male rats. Neuroendocrinology 29: 406, 1979.PubMedCrossRefGoogle Scholar
  9. 9.
    Leadem C.A., Blask D.E. Evidence for an inhibitory influence of the pineal on prolactin in the female rat. Neuroendocrinology 33: 268, 1981.PubMedCrossRefGoogle Scholar
  10. 10.
    Vaughan M.K., Blask D.E., Vaughan G.M., Reiter R.J. Dose-dependent prolactin releasing activity of arginine vasotocin in intact and pinealectomized estrogen-progesterone treated adult male rats. Endocrinology 99: 1319, 1976.PubMedCrossRefGoogle Scholar
  11. 11.
    Demoulin A., Hudson B., Legros J.J., Franchimont P. Influence d’un extract de glandes pinéales ovines sur la libération de prolactin in vitro. C R. Soc. Biol. (Paris) 171: 1134, 1977.Google Scholar
  12. 12.
    Martin J.E., Sattler C. Selectivity of melatonin pituitary inhibitory for luteinizing hormone-releasing hormone. Neuroendocrinology 34: 112, 1982.PubMedCrossRefGoogle Scholar
  13. 13.
    Mauri R., Lissoni P., Resentini M., De Medici C., Morabito F., Djemal S., Di Bella L., Fraschini F. Effects of melatonin on PRL secretion during different photoperiods of the day in prepubertal and pubertal healthy subjects. J. Endocrinol. Invest. 8: 337, 1985.PubMedCrossRefGoogle Scholar
  14. 14.
    Anton-Tay F., Chou C., Anton S., Wurtman R.Y. Brain serotonin concentration: elevation following intraperitoneal administration of melatonin. Biochem. Biophys. Res. Commun 104: 1610, 1982.CrossRefGoogle Scholar
  15. 15.
    Zisapel N., Laudon M. Dopamine release induced by electrical field stimulation of rat hypothalamus in vitro: inhibition by melatonin. Biochem. Biophys. Res. Commun. 104: 1610, 1982.PubMedCrossRefGoogle Scholar
  16. 16.
    Reiter R.J., Blask D.E., Johnson L.Y., Rudeen P.K., Vaughan M.K., Waring P.J. Melatonin inhibition of reproduction in the male hamster: its dependency on time of day of administration and on intact and sympathetically innervated pineal gland. Neuroendocrinology 22: 107, 1976.PubMedCrossRefGoogle Scholar
  17. 17.
    Brown G., Grota L., Bubenik G., Niles L., Tsui H. Physiologic regulation of melatonin. Adv. Sci. 29: 95, 1981.Google Scholar
  18. 18.
    Steger R.W., Reiter R.J., Siler-Khodr T.M. Interactions of pinealectomy and short-photoperiod exposure on the neuroendocrine axis of the male Syrian hamster. Neuroendocrinology 38: 158, 1984.PubMedCrossRefGoogle Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 1990

Authors and Affiliations

  • P. Lissoni
    • 1
  • E. Mainini
    • 2
  • C. Mazzi
    • 2
  • G. Cattaneo
    • 1
  • S. Barni
    • 1
  1. 1.Divisione di Radioterapia OncologicaOspedale S. GerardoMonzaItaly
  2. 2.Divisione di EndocrinologiaOspedale S. Antonio AbateGallarateItaly

Personalised recommendations