Journal of Endocrinological Investigation

, Volume 7, Issue 6, pp 653–657 | Cite as

Cutaneous metastasis of a radiation-associated thyroid medullary carcinoma

  • G. Bevilacqua
  • S. Mariotti
  • M. Castagna
  • C. Marcocci
  • G. C. Di Coscio
  • E. Martino


The rare event of a single cutaneous metastasis occurred in a 37-year-old white man two years after a subtotal thyroidectomy for sporadic medullary carcinoma is reported. The endocrine nature of the tumor is revealed by the ultrastructural study, and the type of secretion by the biochemical assay of calcitonin (CT) in the serum and in the tumor tissue extract and by the PAP (peroxidase-anti-peroxidase) technique with anti-CT antibodies on paraffin sections. The cytological and histological findings are described. Some peculiar ultrastructural aspects are presented in details. The fact that the patient received a course of Rx therapy (3,000 rads) on the neck for cervical syringomyelia at the age of 20 years is stressed.


Thyroid medullary carcinoma metastasis radiation skin calcitonin 


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Copyright information

© Italian Society of Endocrinology (SIE) 1984

Authors and Affiliations

  • G. Bevilacqua
    • 1
  • S. Mariotti
    • 2
  • M. Castagna
    • 1
  • C. Marcocci
    • 3
  • G. C. Di Coscio
    • 1
  • E. Martino
    • 2
  1. 1.Istituto di Anatomia e Istologia PatologicaScuola medicaPisaItaly
  2. 2.Cattedra di Patologia Medica IIUniversity of PisaPisaItaly
  3. 3.Cattedra di Endocrinologia e Medicina CostituzionaleUniversity of PisaPisaItaly

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