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Relationship between ghrelin and anthropometrical, body composition parameters and testosterone levels in boys at different stages of puberty

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Abstract

The aim of this study was to investigate the relationships between fasting serum ghrelin concentration, anthropometrical and body composition data in boys at different pubertal stages. Sixty healthy non-obese Estonian schoolboys (10 to 18 yr) were divided into 3 groups based on Tanner classification — group I was prepubertal, group II included stages 2 and 3, and group III stages 4 and 5. Additionally, we analyzed subjects as a total group. Fasting ghrelin, leptin, testosterone, insulin and glucose were collected between 08:00 and 10:00 h. Body fat % and lean body mass (LBM) were determined by dual-energy X-ray absorptiometry. Fasting ghrelin decreased, while leptin and insulin did not change and testosterone increased during puberty. There was a negative correlation between serum ghrelin and testosterone concentrations in group II (r=−0.51, p<0.05) and in the total group (r=−0.59, p<0.001). Ghrelin was also related to body height, body mass and LBM in group II and total group also with body mass index in total group. Stepwise multiple regression analysis showed that body height from auxological, LBM from body composition and testosterone from biochemical data explained 38.1, 41.7 and 33.7% of the ghrelin variance in the total group, respectively. In conclusion, body height, LBM and serum testosterone are the major determinants of serum ghrelin among parameters studied. Negative correlation between serum ghrelin and testosterone concentrations indicates that ghrelin may also have a role in male pubertal development.

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References

  1. Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB. Ghrelin — a hormone with multiple functions. Front Neuroendocrinol 2004, 25: 27–68.

    Article  CAS  PubMed  Google Scholar 

  2. Broglio F, Arvat E, Benso A, et al. Ghrelin, a natural GH secretagogue produced by the stomach induces hyperglycaemia and reduces insulin secretion in man. J Clin Endocrinol Metabol 2001, 86: 5083–6.

    Article  CAS  Google Scholar 

  3. Date Y, Nakazato M, Murakami N, Kojima M, Kangawa K, Matsukura S. Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem Biophys Res Commun 2001, 280: 904–7.

    Article  CAS  PubMed  Google Scholar 

  4. Tena-Sempere M. Exploring the role of ghrelin as novel regulator of gonadal function. Growth Horm IGF Res 2005, 15: 83–8.

    Article  CAS  PubMed  Google Scholar 

  5. Whatmore AJ, Hall CM, Jones J, Westwood M, Clayton PE. Ghrelin concentrations in healthy children and adolescents. Clin Endocrinol (Oxf) 2003, 59: 649–54.

    Article  CAS  Google Scholar 

  6. Chanoine J-P. Ghrelin in growth and development. Horm Res 2005, 63: 129–38.

    Article  CAS  PubMed  Google Scholar 

  7. Lebenthal Y, Gat-Yablonski G, Shtaif B, Padoa A, Phillip M, Lazar L. Effect of sex hormone administration on circulating ghrelin levels in peripubertal children. J Clin Endocrinol Metab 2006, 91: 328–31.

    Article  CAS  PubMed  Google Scholar 

  8. Bunt JC, Arline DS, Tschop M, Delparigi A, Daychild P, Tataranni A. Cross-sectional and prospective relationships of fasting plasma ghrelin concentrations with anthropometric measures in Pima Indian children. J Clin Endocrinol Metab 2003, 88: 3756–61.

    Article  CAS  PubMed  Google Scholar 

  9. Haqq AM, Farooqi IS, O’Rahilly S, et al. Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome. J Clin Endocrinol Metab 2003, 88: 174–8.

    Article  CAS  PubMed  Google Scholar 

  10. Tschöp M, Weyer C, Tataranni A, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001, 50: 707–9.

    Article  PubMed  Google Scholar 

  11. Soriano-Guillén L, Barrios V, Chowen J, et al. Ghrelin levels from fetal life through early adulthood: relationship with endocrine and metabolic and anthropometric measures. J Pediatr 2004, 144: 30–5.

    Article  PubMed  Google Scholar 

  12. Park HS, Lee K, Kim Y, Park C. Relationships between fasting plasma ghrelin levels and metabolic parameters in children and adolescents. Metabolism 2005, 54: 925–9.

    Article  CAS  PubMed  Google Scholar 

  13. Clayton PE, Gill MS, Hall CM, Tillmann V, Whatmore AJ, Price DA. Serum leptin through childhood and adolescence. Clin Endocrinol (Oxf) 1997, 46: 727–33.

    Article  CAS  Google Scholar 

  14. Ong KK, Ahmed ML, Dunger DB. The role of leptin in human growth and puberty. Acta Paediatr 1999, 88 (Suppl.): 95–8.

    Article  CAS  Google Scholar 

  15. Tanner J. Growth at Adolescence. 2nd ed. Oxford, United Kingdom: Blackwell Scientific Publications. 1962, 121–30.

    Google Scholar 

  16. Duke PM, Litt IF, Gross RT. Adolescents’ self-assessment of sexual maturation. Pediatrics 1980, 66: 918–20.

    CAS  PubMed  Google Scholar 

  17. Grünberg H, Adojaan B, Thetloff M. Growth and growth disorders (in estonian). Tartumaa Printhouse. 1998.

  18. Fernandez-Real JM, Vayreda M, Casamitjana R, Gonzalez-Huix F, Ricart W. The fat-free mass compartment influences serum leptin in men. Eur J Endocrinol 2000, 142: 25–9.

    Article  CAS  PubMed  Google Scholar 

  19. Vivenza D, Rapa A, Castellino N, et al. Ghrelin gene polymorphisms and ghrelin, insulin, IGF-I, leptin and anthropometrics data in children and adolescents. Eur J Endocrinol 2004, 151: 127–33.

    Article  CAS  PubMed  Google Scholar 

  20. Pagotto U, Gambineri A, Pelusi C, et al. Testosterone replacement therapy restores normal ghrelin in hypogonadal men. J Clin Endocrinol Metab 2003, 88: 4139–43.

    Article  CAS  PubMed  Google Scholar 

  21. Fernandez-Fernandez R, Navarro VM, Barreiro ML, et al. Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat. Endocrinology 2005, 14: 3018–25.

    Article  Google Scholar 

  22. Veldhuis JD, Roemmich JN, Richmond EJ, et al. Endocrine control of body composition in infancy, childhood, and puberty. Endocr Rev 2005, 26: 114–46.

    Article  CAS  PubMed  Google Scholar 

  23. Mauras N, Rogol AD, Haymond MW, Veldhuis JD. Sex steroids, growth hormone, insulin-like growth factor-1: neuroendocrine and metabolic regulation in puberty. Horm Res 1996, 45: 74–80.

    Article  CAS  PubMed  Google Scholar 

  24. Akamizu T, Shinomiya T, Irako T, et al. Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay. J Clin Endocrinol Metab 2005, 90: 6–9.

    Article  CAS  PubMed  Google Scholar 

  25. Broglio F, Gottero C, Prodam F, et al. Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans. J Clin Endocrinol Metab 2004, 89: 3062–5.

    Article  CAS  PubMed  Google Scholar 

  26. Marzullo P, Verti B, Savia G, et al. The relationship between active ghrelin levels and human obesity involves alterations in resting energy expenditure. J Clin Endocrinol Metab 2004, 89: 936–9.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Chair of Sport Pedagogy, Center of Behavioral and Health Sciences, University of Tartu, Tartu, Estonia

    T. Pomerants, J. Jürimäe & T. Jürimäe PhD

  2. Department of Pediatrics, University of Tartu, Tartu, Estonia

    V. Tillmann

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  1. T. Pomerants
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  2. V. Tillmann
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  4. T. Jürimäe PhD
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Correspondence to T. Jürimäe PhD.

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Pomerants, T., Tillmann, V., Jürimäe, J. et al. Relationship between ghrelin and anthropometrical, body composition parameters and testosterone levels in boys at different stages of puberty. J Endocrinol Invest 29, 962–967 (2006). https://doi.org/10.1007/BF03349208

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