Abstract
We studied the effect of the acute central administration of obestatin on food intake and body weight in short-term starved male rats, and those of 28-day continuous intracerebroventricular (icv) infusion of obestatin in free feeding rats. In 16-h starved rats, obestatin induced a trend toward a reduction of food intake that did not reach statistical significance. In fed rats, the icv infusion of obestatin significantly decreased food consumption in the first day of treatment; but the anorexigenic effect of obestatin vanished thereafter. Interestingly, the body weight of rats infused for 28 days with obestatin was superimposable to that of the respective control at all time intervals. In all, our results indicate that the anorexigenic effect of obestatin is of little account and that the peptide does not modify energy metabolism in the long-term administration.
Similar content being viewed by others
References
Zhang JV, Ren PG, Avsian-Kretchmer O, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake. Science 2005, 5750: 996–9.
Szentirmai E, Krueger JM. Obestatin alters sleep in rats. Neurosci Lett 2006, 1–2: 222–6.
Samson WK, White MM, Price C, Ferguson AV. Obestatin acts in brain to inhibit thirst. Am J Physiol Regul Integr Comp Physiol 2006 [Epub ahead of print].
Gourcerol G, Million M, Adelson DW, Wang Y, et al. Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodents. Peptides 2006, 27: 2811–9.
Holst B, Egerod KL, Schild E, et al. GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology 2006 [Epub ahead of print].
Seoane LM, Al-Massadi O, Pazos Y, Pagotto U, Casanueva FF. Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats. J Endocrinol Invest 2006, 29: RC13–5.
Lauwers E, Landuyt B, Arckens L, Schoofs L, Luyten W. Obestatin does not activate orphan G protein-coupled receptor GPR39. Biochem Biophys Res Commun 2006, 351: 21–5.
Guidobono F, Coluzzi M, Pagani F, Pecile A, Netti C. Amylin given by central and peripheral routes inhibits acid gastric secretion. Peptides 1994, 15: 699–702.
Yamamoto D, Ikeshita N, Daito R, et al. Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats. Regul Pept 2006 [Epub ahead of print].
Nogueiras R, Pfluger P, Tovar S, et al. Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology 2006 [Epub ahead of print].
Bresciani E, Rapetti D, Donà F, et al. Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat. J Endocrinol Invest 2006, 29: RC16–8.
Pan W, Tu H, Kastin AJ. Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin. Peptides 2006, 27: 911–6.
Moechars D, Depoortere I, Moreaux B, et al. Altered gastrointestinal and metabolic function in the GPR39-obestatin receptor-knockout mouse. Gastroenterology 2006, 131: 1131–41.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sibilia, V., Bresciani, E., Lattuada, N. et al. Intracerebroventricular acute and chronic administration of obestatin minimally affect food intake but not weight gain in the rat. J Endocrinol Invest 29, RC31–RC34 (2006). https://doi.org/10.1007/BF03349204
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03349204