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Journal of Endocrinological Investigation

, Volume 29, Issue 11, pp RC31–RC34 | Cite as

Intracerebroventricular acute and chronic administration of obestatin minimally affect food intake but not weight gain in the rat

  • V. Sibilia
  • E. Bresciani
  • N. Lattuada
  • D. Rapetti
  • V. Locatelli
  • V. De Luca
  • F. Donà
  • C. Netti
  • A. Torsello
  • F. Guidobono
Rapid Communication

Abstract

We studied the effect of the acute central administration of obestatin on food intake and body weight in short-term starved male rats, and those of 28-day continuous intracerebroventricular (icv) infusion of obestatin in free feeding rats. In 16-h starved rats, obestatin induced a trend toward a reduction of food intake that did not reach statistical significance. In fed rats, the icv infusion of obestatin significantly decreased food consumption in the first day of treatment; but the anorexigenic effect of obestatin vanished thereafter. Interestingly, the body weight of rats infused for 28 days with obestatin was superimposable to that of the respective control at all time intervals. In all, our results indicate that the anorexigenic effect of obestatin is of little account and that the peptide does not modify energy metabolism in the long-term administration.

Key-words

Obestatin food intake ghrelin body weight 

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Copyright information

© Italian Society of Endocrinology (SIE) 2006

Authors and Affiliations

  • V. Sibilia
    • 1
  • E. Bresciani
    • 2
  • N. Lattuada
    • 1
  • D. Rapetti
    • 2
  • V. Locatelli
    • 2
    • 3
  • V. De Luca
    • 1
  • F. Donà
    • 2
  • C. Netti
    • 1
  • A. Torsello
    • 2
    • 3
  • F. Guidobono
    • 1
  1. 1.Department of Pharmacology, Chemoterapy, and Medical ToxicologyUniversity of MilanMilanItaly
  2. 2.Department of Experimental MedicineUniversity of Milan-BicoccaMonzaItaly
  3. 3.Interdepartmental Center for Bioinformatics and ProteomicsUniversity of Milan-BicoccaMonzaItaly

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