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Journal of Endocrinological Investigation

, Volume 16, Issue 6, pp 449–460 | Cite as

Advances in the medical and surgical treatment of pituitary adenomas: The role of long-acting somatostatin analogs

  • R. Fahlbusch
  • M. Giovanelli
  • M. Buchfelder
  • M. Losa
Consensus Statement

Key-words

Pituitary adenoma acromegaly transsphenoidal surgery octreotide 

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References

  1. 1.
    Reubi J.C., Landolt A.M. The growth hormone responses to octreotide in acromegaly correlate with adenoma somatostatin receptor status. J. Clin. Endocrinol. Metab. 68: 844, 1989.PubMedCrossRefGoogle Scholar
  2. 2.
    Spada A., Reza-Elahi F., Lania A., Gil del Alamo P., Bassetti M., Faglia G. Alterations in receptor status and postreceptor events in human pituitary tumors. In: Faglia G., Beck-Peccoz P., Ambrosi B., Travaglini P., Spada A. (Eds.), Pituitary adenomas: New trends in basic and clinical research. Excerpta Medica, Amsterdam, 1991, p. 95.Google Scholar
  3. 3.
    Schonbrunn A. Somatostatin action in pituitary cells involves two independent transduction mechanisms. Metabolism. 39 (Suppl. 2): 96, 1990.PubMedCrossRefGoogle Scholar
  4. 4.
    Daughaday W.H., Starkey R.H., Saltman S., Gavin J.R. III, Mills-Dunlap B., Heath-Monnig E. Characterization of serum growth hormone (GH) and insulin-like growth factor I in active acromegaly with minimal elevation of serum GH. J. Clin. Endocrinol. Metab. 65: 617, 1987.PubMedCrossRefGoogle Scholar
  5. 5.
    Clemmons D.R., Van Wyk J.J., Ridgway E.C., Kliman B., Kjellberg R.N., Underwood L.E. Evaluation of acromegaly by radioimmunoassay of Somatomedin-C. N. Engl. J. Med. 301: 1138, 1977.CrossRefGoogle Scholar
  6. 6.
    Chiodini P.G., Liuzzi A., Botalla L., Oppizzi G., Müller E.E., Silvestrini F. Stable reduction of plasma growth hormone (hGH) levels during chronic administration of 2 Br-alfa-ergocryptine (CB 154) in acromegalic patients. J. Clin. Endocrinol. Metab. 40: 705, 1975.PubMedCrossRefGoogle Scholar
  7. 7.
    Plewe G., Beyer J., Krause U., Neufeld M., Del Pozo E. Long-acting and selective suppression of growth hormone secretion by somatostatin analogue SMS 201–995 in acromegaly. Lancet 2: 782, 1984.PubMedCrossRefGoogle Scholar
  8. 8.
    Lamberts S.W.J., Oosterom R., Neufeld M., Del Pozo E The somatostatin analog SMS 201–995 induces longacting inhibition of growth hormone secretion without rebound hypersecretion in acromegalic patients. J. Clin. Endocrinol. Metab. 60: 1161, 1985.PubMedCrossRefGoogle Scholar
  9. 9.
    Harris A.G., Prestele H., Herold K., Boerlin V. Long-term efficacy of Sandostatin (SMS 201–995, octreotide) in 178 patients: results from the international multicenter acromegaly study group. In: Lamberts S.W.J. (Ed.), Sandostatin in the treatment of acromegaly. Springer, Berlin 1988, pp. 117.CrossRefGoogle Scholar
  10. 10.
    Tauber J.P., Babin T., Tauber M.T., Vigoni F., Bonafe A., Ducasse M., Harris A.G., Bayard F. Long-term effects of continuous subcutaneous infusion of the somatostatin analog octreotide in the treatment of acromegaly. J. Clin. Endocrinol. Metab. 68: 917, 1989.PubMedCrossRefGoogle Scholar
  11. 11.
    Lamberts S.W.J., Uitterlinden P., Schnijff P.C., Klijn J.G.M. Therapy of acromegaly with Sandostatin: the predictive value of an acute test, the value of somatomedin-C measurements in dose adjustment and the definition of a biochemical “cure”. Clin. Endocrinol. (Oxf) 29: 411, 1988.CrossRefGoogle Scholar
  12. 12.
    Giovanelli M., Losa M., Baiguini M., Motti E., Ducati A. Transcranial vs. transsphenoidal approach in the surgical treatment of pituitary adenomas. In: Faglia G., Beck-Peccoz P., Ambrosi B., Travaglini P., Spada A. (Eds.), Pituitary adenomas: New trends in basic and clinical research. Excerpta Medica, Amsterdam 1991, p. 313.Google Scholar
  13. 13.
    Ross D.A., Wilson C.B. Results of transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma in a series of 214 patients. J. Neurosurg. 68: 854, 1988.PubMedCrossRefGoogle Scholar
  14. 14.
    Landolt A.M., Lllig R., Zapf J. Surgical treatment of acromegaly. In: Lamberts S.W.J. (Ed.), Sandostatin in the treatment of acromegaly. Springer, Berlin, 1988, pp. 23.CrossRefGoogle Scholar
  15. 15.
    Losa M., Oeckler R., Schopohl J., Müller O.A., Alba-Lopez J., von Werder K. Evaluation of selective transsphenoidal adenomectomy by endocrinological testing and somatomedin-C measurement in acromegaly. J. Neurosurg. 70: 561, 1989.PubMedCrossRefGoogle Scholar
  16. 16.
    Falhbusch R., Buchfelder M., Huk W.J., Nistor R., Steinmeier R., Zrinzo A. Correlation between MRI and intraoperative findings in pituitary adenomas. In: Faglia G., Beck-Peccoz P., Ambrosi B., Travaglini P., Spada A. (Eds.), Pituitary adenomas: New trends in basic and clinical research. Excerpta Medica, Amsterdam, 1991, pp. 245.Google Scholar
  17. 17.
    Barkan A., Lloyd R.V., Chandler W.F., Hatfield M.K., Gebarski S.S., Kelch R.P., Beitins I.Z. Preoperative treatment of acromegaly with long-acting somatostatin analog SMS 201–995: Shrinkage of invasive pituitary macroadenomas and improved surgical remission rate. J. Clin. Endocrinol. Metab. 67: 1040, 1988.PubMedCrossRefGoogle Scholar
  18. 18.
    Nicola G.C., Tonnarelli G., Griner A.C., Zancaner F., Picozzi P., Roccucci P. Surgery for recurrence of pituitary adenomas. In: Faglia G., Beck-Peccoz P., Ambrosi B., Travaglini P., Spada A. (Eds.), Pituitary adenomas: New trends in basic and clinical research. Excerpta Medica, Amsterdam, 1991, p. 329.Google Scholar
  19. 19.
    Laws E.R. Jr., Fode N.C., Redmond M.J. Transsphenoidal surgery following unsuccessful prior therapy. An assessment of benefits and risks in 158 patients. J. Neurosurg. 63: 823, 1985.PubMedCrossRefGoogle Scholar
  20. 20.
    D’Enideu M.C., Harrison L.C. Rapid improvement in visual field defects following bromocriptine treatment of patients with non-functioning pituitary adenomas. Clin. Endocrinol. (Oxf) 25: 697, 1986.CrossRefGoogle Scholar
  21. 21.
    Warnet A., Timsit J., Chanson P., Guillausseau P.J., Zamfirescu F., Harris A.G., Derome P., Cophignon J., Lubetzki J. The effect of somatostatin analogue on chiasmal dysfunction from pituitary macroadenomas. J. Neurosurg. 71: 687, 1989.PubMedCrossRefGoogle Scholar
  22. 22.
    Faglia G., Bazzoni N., Spada A., Arosio M., Ambrosi B., Spinelli F., Sara R., Bonino C., Lunghi F. In vivo detection of somatostatin receptors in patients with functionless pituitary adenoma by means of a radioiodinated analog of somatostatin ([123-I] SDZ 204-090). J. Clin. Endocrinol. Metab. 73: 850, 1991.PubMedCrossRefGoogle Scholar
  23. 23.
    Oppenheim D.S., Klibanski A. Medical therapy of glycoprotein hormone-secreting pituitary tumors. Endocr. Metab. Clin. North Am. 18: 339, 1989.Google Scholar
  24. 24.
    Ebersold M.J., Quast L.M., Laws E.R. Jr. Long-term results in transsphenoidal removal of nonfunctioning pituitary adenomas. J. Neurosurg. 64: 713, 1986.PubMedCrossRefGoogle Scholar
  25. 25.
    Kovalic J.J., Grigsby P.W., Fineberg B.B. Recurrent pituitary adenomas after surgical resection: The role radiation therapy. Radiology 177: 273, 1990.PubMedGoogle Scholar
  26. 26.
    Molitch M.E., Russell E.J. The pituitary “incidentaloma”. Ann. Intern. Med. 112: 925, 1990.PubMedCrossRefGoogle Scholar
  27. 27.
    Buchfelder M., Fahlbusch R., Becher W., Mann H. TSH-sezernierende Hypophysenadenome. Med. Welt 42: 1033, 1991.Google Scholar
  28. 28.
    Gesundheit N., Petrich P.A., Nissim M., Dahlberg A., Doppman J.L., Emerson C.H., Lewis E., Braverman LE., Oldfield E.H., Weintraub B.D. Thyrotropin-secreting pituitary adenomas: Clinical and biochemical heterogeneity. Case reports and follow-up of nine patients. Ann. Intern. Med. 111: 827, 1987.CrossRefGoogle Scholar
  29. 29.
    Beckers A., Abs R., Mahler C., Vandalem J.L., Pirens G., Hennen G., Stevenaert A. Thyrotropin-secreting pituitary adenomas: Report of seven cases. J. Clin. Endocrinol. Metab. 72: 477, 1991.Google Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 1993

Authors and Affiliations

  • R. Fahlbusch
    • 1
  • M. Giovanelli
    • 2
  • M. Buchfelder
    • 1
  • M. Losa
    • 2
  1. 1.Neurochirurgische Klinik der Universität Erlangen-NürnbergErlangenGermany
  2. 2.Cattedra di Neurochirurgia, IRCCS San RaffaeleUniversità di MilanoMilanItaly

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