Journal of Endocrinological Investigation

, Volume 7, Issue 3, pp 253–256 | Cite as

Growth-hormone releasing factor and clonidine in children with constitutional growth delay. Evidence for defective pituitary growth hormone reserve

  • C. Pintor
  • R. Puggioni
  • V. Fanni
  • S. G. Cella
  • A. Villa
  • V. Locatelli
  • E. E. Müller
Short Communication


Six male prepubertal children with constitutional growth delay (CGD), and a subnormal growth hormone (GH) response to insulin hypoglycemia, and four normal prepubertal children were given in different occasions 1 μg/Kg iv synthetic hpGRF-40 or a single oral dose of 0.15 mg/m2 clonidine (Clon), an effective growth hormone (GH) secretagogue. In the normal children brisk and clear-cut GH rises were detected in plasma after hpGRF-40 (peak GH levels at 15–30 min) or clonidine (peak GH levels 60–90 min). In CGD children hpGRF-40 induced a biphasic response, e.g. a slight increase in plasma GH at 15 min followed by a delayed and erratic GH rise occurring 45–120 min post-injection. Also the GH response to Clon was sluggish and delayed and peak plasma GH levels were attained only 90–180 min post-drug administration. These data indicate that the CGD children of our study have a defect in the pituitary GH reserve.


Human pancreatic GRF-40 clonidine GH release constitutional growth delay pituitary GH reserve 


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Copyright information

© Italian Society of Endocrinology (SIE) 1984

Authors and Affiliations

  • C. Pintor
    • 1
  • R. Puggioni
    • 1
  • V. Fanni
    • 1
  • S. G. Cella
    • 2
  • A. Villa
    • 3
  • V. Locatelli
    • 2
  • E. E. Müller
    • 2
  1. 1.1° Dipartimento di PediatriaUniversità di CagliariItalia
  2. 2.Dipartimento di Farmacologia, Chemioterapia, e TossicologiaUniversità di MilanoMilanoItalia
  3. 3.Maggioni Farmaceutici S.p.A.MilanoItalia

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