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Journal of Endocrinological Investigation

, Volume 7, Issue 3, pp 207–209 | Cite as

Long-term variations in plasma gonadotropins in early castrated male rabbits

  • M. Berger
  • Ch. Jean-Faucher
  • M. De Turckheim
  • G. Veyssiere
  • Cl. Jean
Article
  • 3 Downloads

Abstract

LH and FSH levels were determined by RIA in plasma samples collected every 10 days from 30 to 90 days and at 4, 5 and 6 months in control male rabbits and in rabbits castrated at 30 days of age. At all stages studied gonadotropin levels were significantly increased in castrates. Mean LH levels were not influenced by age in controls or in castrates. Mean FSH levels were age dependent and increased during sexual maturation in both groups. The results showed that the secretion of FSH, but not that of LH, may be stimulated during prepubertal and pubertal stages in males where steroidal inhibition is absent.

Key-words

Rabbit castration FSH LH puberty 

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References

  1. 1.
    Ramirez V.D., Mc Cann S.M. Comparison of the regulation of luteinizing hormone (LH) secretion in immature and adult rats. Endocrinology 72: 452, 1963.PubMedCrossRefGoogle Scholar
  2. 2.
    Ramirez V.D., Mc Cann S.M. Inhibitory effect of testosterone on luteinizing hormone secretion in immature and adult rats. Endocrinology 76: 412, 1965.PubMedCrossRefGoogle Scholar
  3. 3.
    Yamamoto M., Diebel N., Bogdanove E.M. Analysis of initial and delayed effects of orchidectomy and ovariectomy on pituitary and serum LH levels in adult and immature rats. Endocrinology 86: 1102, 1970.PubMedCrossRefGoogle Scholar
  4. 4.
    Goldman B.D., Grazia Y.R., Kamberi I.A., Porter J.C. Serum gonadotropin concentrations in intact and castrated neonatal rats. Endocrinology 88: 771, 1971.PubMedCrossRefGoogle Scholar
  5. 5.
    Swerdloff R.S., Walsh P.C., Jacobs H.S., Odel W.D. Serum FSH and LH during sexual maturation in the male rat: effect of castration and cryptorchidism. Endocrinology 88: 120, 1971.PubMedCrossRefGoogle Scholar
  6. 6.
    Winter J.S.D., Faiman C. Serum gonadotropin concentrations in agonadal children and adults. J. Clin. Endocrinol. Metab. 35: 561, 1972.PubMedCrossRefGoogle Scholar
  7. 7.
    Berger M., J-ean-Faucher Ch., De Turckheim M., Veyssiere G., Jean C.I. Age-related changes in the feed-back regulation of gonadotropin secretion in the immature and adult male rabbit. Acta Endocrinol. (Kbh) 100: 18, 1982.Google Scholar
  8. 8.
    Kulin H.E., Grumbach M.M., Kaplan S.L. Gonadal-hypothalamic interaction in prepubertal and pubertal man: effect of clomiphene citrate on urinary follicle-stimulating hormone, luteinizing hormone and plasma testosterone. Pediatr. Res. 6: 162, 1972.PubMedCrossRefGoogle Scholar
  9. 9.
    Raum W.J., Glass A. R., Swerdloff R.S. Changes in hypothalamic catecholamine neurotransmitters and pituitary gonadotropins in the immature female rat: relationships to the gonadostat theory of puberty onset. Endocrinology 106: 1253, 1980.PubMedCrossRefGoogle Scholar
  10. 10.
    Conte F.A., Grumback M.M., Kaplan S.L. A diphasic pattern of gonadotropin secretion in patients with the syndrome of gonadal dysgenesis. J. Clin. Endocrinol. Metab. 40: 670, 1975.PubMedCrossRefGoogle Scholar
  11. 11.
    Boyar R.M., Rosenfeld R.S., Kapen S., Finkeldtein J.W., Roffwarg H.P., Weitzman E.D., Hellman L. Human puberty. Simultaneous augmented secretion of luteinizing hormone and testosterone during sleep. J. Clin. Invest. 54: 609, 1974.PubMedCentralPubMedCrossRefGoogle Scholar
  12. 12.
    Weitzman E.D., Boyar R.M., Kapen S., Hellman L. The relationship of sleep and sleep stages to neuroendocrine secretion and biological rhythms in man. Rec. Progr. Horm. Res. 31: 399, 1975.PubMedGoogle Scholar
  13. 13.
    Lacroix A., Pelletier J. Short-term variations in plasma LH and testosterone in bull calves from birth to 1 year of age. J. Reprod. Fert. 55: 81, 1979.CrossRefGoogle Scholar
  14. 14.
    Foster D.L., Jaffe R.B., Niswender G.D. Sequential patterns of circulating LH and FSH in female sleep during the early postnatal period: effect of gona-dectomy. Endocrinology 96: 15, 1975.PubMedCrossRefGoogle Scholar
  15. 15.
    Colenbrander B., Van Straaten H.W.M. Serum LH levels and Leydig Cell development in the pig. Acta Morphol Neerl. Scand. 15: 102, 1977 (Abstract).PubMedGoogle Scholar
  16. 16.
    Sherwood N.M., Timiras P.S. Comparison of direct-current and radio-frequency-current lesions in the rostral hypothalamus with respect to sexual maturation in the female rat. Endocrinology 94: 1275, 1974.PubMedCrossRefGoogle Scholar
  17. 17.
    Berger M., Corre M., Jean-Faucher Ch., De Turckheim M., Veyssiere G., Jean CI. Changes in the testosterone to dihydrotestosterone ratio in plasma and testes of maturing rabbits. Endocrinology 104: 1450, 1979.PubMedCrossRefGoogle Scholar
  18. 18.
    Berger M., Jean-Faucher Ch., De Turckheim M., Veyssiere G., Blanc M.R., Poirier J.C., Jean C.I. Testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in plasma of rabbit from birth to adulthood. Correlation with sexual and behavioural development. Acta Endocrinol. (Kbh) 99: 459, 1982.Google Scholar
  19. 19.
    Berger M., Corre M., Jean-Faucher Ch., De Turckheim M., Veyssiere G., Jean C.I. Age related changes in percent binding of testosterone and dihydrotestosterone and unbound testosterone and dihydrotestosterone in rabbit plasma. J. Steroid Biochem. 13: 423, 1980.PubMedCrossRefGoogle Scholar
  20. 20.
    Chubb C., Ewing L., Irby D., Desjardins C. Testicular maturation in the rabbit: secretion of testosterone, dihydrotestosterone, 5 α-androstan-3β, 17β-diol and 5 α-androstan-3β, 17β-diol by perfused rabbit testes-epididymides and spermatogenesis. Biol. Reprod. 18: 212, 1978.PubMedCrossRefGoogle Scholar
  21. 21.
    Ketelslegers J.M., Hetzel W.D., Sherins R., Catt K.J. Developmental changes in testicular gonadotropin receptors: plasma gonadotropins and plasma testosterone in the rat. Endocrinology 103: 212, 1978.PubMedCrossRefGoogle Scholar
  22. 22.
    Berger M., Jean-Faucher Ch., De Turckheim M., Veyssiere G., Jean C.I. Pituitary luteinizing hormone and follicle stimulating hormone from birth to adulthood in male rabbit. Changes in the pituitary responsiveness to LHRH injection. Horm. Res. 15: 242, 1981.PubMedCrossRefGoogle Scholar
  23. 23.
    Conte F.A., Grumbach M.M., Kaplan S.L., Reiter E.O. Correlation of luteinizing hormone-releasing factor in-duced luteinizing hormone and follicle-stimulating hormone release from infancy to 19 years with the changing pattern of gonadotropin secretion in agonadal patients: relation to the restraint of puberty. J. Clin. Endocrinol. Metab. 50: 163, 1980.PubMedCrossRefGoogle Scholar
  24. 24.
    Swerdloff R.S., Heber D. Endocrine control of testicular function from birth to puberty. In: Burger H., De Kretser D. (Eds), The testis. Raven Press, New York, 1981, p. 107.Google Scholar
  25. 25.
    De Turckheim M., Berger M., Jean-Faucher Ch., Veyssiere G., Jean C.I. Changes in ovarian oestrogens and in plasma gonadotropins in female rabbits from birth to adulthood. Acta Endocrinol. (Kbh) 103: 125, 1983.Google Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 1984

Authors and Affiliations

  • M. Berger
    • 1
  • Ch. Jean-Faucher
    • 1
  • M. De Turckheim
    • 1
  • G. Veyssiere
    • 1
  • Cl. Jean
    • 1
  1. 1.Physiologie Comparée et EndocrinologyUniversité Clermont II, Complexe Scientifique des CézeauxAubiereFrance

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