Journal of Endocrinological Investigation

, Volume 7, Issue 2, pp 97–102 | Cite as

Content and heterogeneity of distribution of iodine in human and bovine thyroid glands determined by neutron activation analyses

  • J. Handl
  • W. Kühn
  • R. D. Hesch


While performing activation analytical investigations on the actual concentration of the long-lived radioactive 129iodine in human and bovine thyroid glands the absolute natural nonradioactive127 iodine content was determined. In all thyroid glands an uneven distribution of 127I was found (in human thyroids from 0 to 0.75 μg 127l/mg, in bovine thyroids from 0 to 3.5 μg 127l/mg). The mean value of iodine concentration in human thyroid glands ranged from 230 μg/g to 490 μg/g. This is important because TSH independent autonomy is found at a cellular and follicular level during the development from diffuse to nodular goiter. Both processes may, however, not be related to each other. The resolution of the method used in our study is between the microscopic and the scintigraphic level with an accuracy of ± 1%, and it shows an intermediate heterogeneity of iodine in thyroid glands.


Human thyroid iodine distribution activation analysis 


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  1. 1.
    Studer H., Hunziker H.R., Ruchti C. Morphologic and functional substrate of thyrotoxicosis caused by nodular goiter. Am. J. Med. 65: 227, 1978.PubMedCrossRefGoogle Scholar
  2. 2.
    Euratom Progress Report Programme “Radiation Protection” (1976–1980) EUR 7169 DE/EN/Fr Commission of the European Communities, Brussels, Belgium, 1980, p. 313.Google Scholar
  3. 3.
    Handl J., Kühn W. Activation analytical determination of lodine-129 in bovine-thyroid glands. J. Radioanalytical Chemistry 56: 213, 1980.CrossRefGoogle Scholar
  4. 4.
    Amiel S. Nondestructive activation analysis, studies in analytical chemistry 3. Elsevier, Amsterdam, 1981.Google Scholar
  5. 5.
    Glubrecht H., Kühn W. Indikatoraktivierungsmethode. Thiemig-Taschenbücher Band 59: 1976.Google Scholar
  6. 6.
    Milioni E., Studer H. Functional and morphologic particularities of the autonomous follicles in human goiters. J. Mol. Med. 4: 7, 1980.Google Scholar
  7. 7.
    Milioni E., Forster R., Weber M., Berchthold R. Studer H. Autoradiographic studies on the functional autonomy of follicles and nodules in euthyroid human goiters. Ann. Endocrinol. (Paris) 40: 55A, 1979.Google Scholar
  8. 8.
    Josef K., Mahlstedt R., Gonnermann R., Herbert K., Welcke U. Early recognition and evaluation of the risk of hyperthyroidism in thyroid autonomy in an endemic goiter area. J. Mol. Med. 4: 21, 1980.Google Scholar
  9. 9.
    Melander A., Bulkow K., Burger A., Ericson L.E., Ingemannsson S., Ljunggren I.G., Noberg K.A., Persson B., Sundquist S.B., Sundler F., Tibblin S., Westgren U. Influence of the sympathic nervous system on thyroid activity in man. In: Robbins J., Braverman L. (Eds.), Thyroid research. Excerpta Medica, Amsterdam, 1976, p. 100.Google Scholar
  10. 10.
    Pickardt C.R., Habermann J., Leisner B, Witte A., Scriva P.C. Anderungen des 127Jodgehaltes der Schilddrüse und der Schilddrüsenfunktion nach einmaliger Jodinkorporation bei Schilddrüsengesunden und Strumaträgem mit endimischem Jodmangel. Immunhyperthyreose und disseminierte Schilddrüsenautonomie, Sektion Schilddrüse der Dtsch Ges Endokrinologie, Berlin, 1980 p. 72.Google Scholar
  11. 11.
    Edwards R.R. Iodine-129: Its occurrence in nature and its utility as a tracer. Science 137: 851, 1962.PubMedCrossRefGoogle Scholar
  12. 12.
    Ballad R.V., Tan S.H., Johnson J.E., Holman D.W. Hennecke F.W., Manuel O.K. Iodine-129 in man, cow and deer. Health Phys. 34: 691, 1978.PubMedCrossRefGoogle Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 1984

Authors and Affiliations

  • J. Handl
    • 1
  • W. Kühn
    • 1
  • R. D. Hesch
    • 2
  1. 1.Institut für Angew. PhysikAbteilung für Okologische Physik der Gesellschaft für Strahlen und UmweltforschungMünchen-HannoverWest Germany
  2. 2.Medizinische Hochschule HannoverAbtlg. für Klinische Endokrinologie, Zentrum Innere MedizinHannoverWest Germany

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