Glucocorticoids are known to have acute effects on glucose and free fatty acid (FFA) metabolism. The effects of the longstanding hypercorticism of Cushing’s syndrome were studied by isotopic techniques in a group of Cushingoid patients compared to a control group. In the Cushing’s group, glucose production and utilization rates were significantly higher than in control subjects, while FFA turnover also tended to be higher, but not significantly. It is suggested that increased glucose production is the main cause of the hyperglycemia seen in Cushing’s syndrome.
Hall S.E.H., Saunders J., Sonksen P.H. Glucose and free fatty acid turnover in normal subjects and in diabetic patients before and after insulin treatment. Diabetologia 16: 297, 1979.PubMedCrossRefGoogle Scholar
Lecocq F.R., Mebane D., Madison L.L The acute effect of hydrocortisone on hepatic glucose output and peripheral glucose utilization. J. Clin. Invest. 43: 237, 1964.PubMedCentralPubMedCrossRefGoogle Scholar
Randle P.J., Hales C.N., Garland P.B., Newsholme E.A. The glucose-fatty acid cycle. Its role in insulin sensitivity and metabolic disturbance of diabetes mellitus. Lancet 1: 785, 1963.PubMedCrossRefGoogle Scholar